Abstract:
:In Saccharomyces cerevisiae, mothers and daughters have distinct fates. We show that Cbk1 kinase and its interacting protein Mob2 regulate this asymmetry by inducing daughter-specific genetic programs. Daughter-specific expression is due to Cbk1/Mob2-dependent activation and localization of the Ace2 transcription factor to the daughter nucleus. Ectopic localization of active Ace2 to mother nuclei is sufficient to activate daughter-specific genes in mothers. Eight genes are daughter-specific under the tested conditions, while two are daughter-specific only in saturated cultures. Some daughter-specific gene products contribute to cell separation by degrading the cell wall. These experiments define programs of gene expression specific to daughters and describe how those programs are controlled.
journal_name
Celljournal_title
Cellauthors
Colman-Lerner A,Chin TE,Brent Rdoi
10.1016/s0092-8674(01)00596-7subject
Has Abstractpub_date
2001-12-14 00:00:00pages
739-50issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(01)00596-7journal_volume
107pub_type
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