Abstract:
:The pair-rule segmentation gene hairy (h) is expressed and required in alternate metameres in the early Drosophila embryo. We show that h expression outside these domains, driven by an hsp70 promoter, suppresses the expression of fushi tarazu (ftz). The kinetics of action favor h acting directly as a transcriptional repressor. The resulting pattern defects, and the patterns of en and Ubx activity, can be explained if h acts via ftz and other pair-rule genes in the establishment of stable en domains. We present evidence that ftz is required for the initiation of Ubx transcription, but not for its maintenance.
journal_name
Celljournal_title
Cellauthors
Ish-Horowicz D,Pinchin SMdoi
10.1016/0092-8674(87)90636-2subject
Has Abstractpub_date
1987-11-06 00:00:00pages
405-15issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(87)90636-2journal_volume
51pub_type
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