Function of retinoic acid receptor gamma in the mouse.

abstract：:Purified budded virions of Autographa californica nuclear polyhedrosis virus (AcNPV) contain abundant amounts of free ubiquitin, which has an altered electrophoretic mobility on SDS gels as compared with standard ubiquitin. Phase extraction of virion proteins with Triton X-114 indicated that the modified form of ubiqu...

journal_title：Cell

authors： Guarino LA,Smith G,Dong W

更新日期：1995-01-27 00:00:00

abstract：:Thyroid hormone (T3) and retinoic acid (RA) receptors mediate ligand-dependent inhibition of epidermal growth factor (EGF) receptor and c-erbB2/neu promoter activities. Ligand-activated T3 and RA receptors act via a 36 bp 5' fragment of the EGF receptor gene in vivo and, in the presence of nuclear extract, bind with h...

journal_title：Cell

authors： Hudson LG,Santon JB,Glass CK,Gill GN

更新日期：1990-09-21 00:00:00

abstract：:During aging, stromal functions are thought to be impaired, but little is known whether this stems from changes of fibroblasts. Using population- and single-cell transcriptomics, as well as long-term lineage tracing, we studied whether murine dermal fibroblasts are altered during physiological aging under different di...

journal_title：Cell

authors： Salzer MC,Lafzi A,Berenguer-Llergo A,Youssif C,Castellanos A,Solanas G,Peixoto FO,Stephan-Otto Attolini C,Prats N,Aguilera M,Martín-Caballero J,Heyn H,Benitah SA

更新日期：2018-11-29 00:00:00

abstract：:The low-complexity (LC) domains of the products of the fused in sarcoma (FUS), Ewings sarcoma (EWS), and TAF15 genes are translocated onto a variety of different DNA-binding domains and thereby assist in driving the formation of cancerous cells. In the context of the translocated fusion proteins, these LC sequences fu...

journal_title：Cell

authors： Kwon I,Kato M,Xiang S,Wu L,Theodoropoulos P,Mirzaei H,Han T,Xie S,Corden JL,McKnight SL

更新日期：2013-11-21 00:00:00

abstract：:Rosalind Franklin provided the key data for deriving the double helix structure of DNA. The English chemist also pioneered structural studies of colloids, viruses, and RNA. To celebrate the 100th anniversary of Franklin's birth, I summarize her work, which shaped the emerging discipline of molecular biology. ...

journal_title：Cell

authors： Cramer P

更新日期：2020-08-20 00:00:00

abstract：:Recently, a Drosophila gene has been identified, extradenticle, whose product modulates the morphological consequences of homeotic selector genes. We show here that extradenticle protein raises the DNA binding specificity of Ultrabithorax and abdominal-A but not that of Abdominal-B. We further show that extradenticle ...

journal_title：Cell

authors： van Dijk MA,Murre C

更新日期：1994-08-26 00:00:00

abstract：:In this issue of Cell, a study by Valerie Mizrahi and her colleagues suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations. This may be an important mechanism for generating drug-resistant strains of...

journal_title：Cell

authors： Friedberg EC,Fischhaber PL

更新日期：2003-04-18 00:00:00

abstract：:The mec-3 gene is essential for proper differentiation of the set of six touch receptor neurons in C. elegans. In mutants lacking mec-3 activity, the touch receptors express none of their unique differentiated features and appear to be transformed into other types of neurons. We cloned the mec-3 gene by transposon tag...

journal_title：Cell

authors： Way JC,Chalfie M

更新日期：1988-07-01 00:00:00

abstract：:The global financial crisis has hit biotech companies hard both in the US and Europe as venture capital dries up. Finding new sources of long-term financing for translating research into new therapeutics will be essential for maintaining innovation and new drug development by biotech companies. ...

journal_title：Cell

authors： Karberg S

更新日期：2009-08-07 00:00:00

abstract：:The genetic dependencies of human cancers widely vary. Here, we catalog this heterogeneity and use it to identify functional gene interactions and genotype-dependent liabilities in cancer. By using genome-wide CRISPR-based screens, we generate a gene essentiality dataset across 14 human acute myeloid leukemia (AML) ce...

journal_title：Cell

authors： Wang T,Yu H,Hughes NW,Liu B,Kendirli A,Klein K,Chen WW,Lander ES,Sabatini DM

更新日期：2017-02-23 00:00:00

abstract：:Human hepatitis B virus core protein expressed in E. coli assembles into two sizes of particle. We have determined their three-dimensional structures by electron cryomicroscopy and image processing. The large and small particles correspond to triangulation number T = 4 and T = 3 dimer clustered packings, containing 24...

journal_title：Cell

authors： Crowther RA,Kiselev NA,Böttcher B,Berriman JA,Borisova GP,Ose V,Pumpens P

更新日期：1994-06-17 00:00:00

abstract：:The microtubule-based metaphase spindle is subjected to forces that act in diverse orientations and over a wide range of timescales. Currently, we cannot explain how this dynamic structure generates and responds to forces while maintaining overall stability, as we have a poor understanding of its micromechanical prope...

journal_title：Cell

authors： Shimamoto Y,Maeda YT,Ishiwata S,Libchaber AJ,Kapoor TM

更新日期：2011-06-24 00:00:00

abstract：:We have used confocal videomicroscopy in real time to delineate the adhesive interactions supporting platelet thrombus formation on biologically relevant surfaces. Type I collagen fibrils exposed to flowing blood adsorb von Willebrand factor (vWF), to which platelets become initially tethered with continuous surface t...

journal_title：Cell

authors： Savage B,Almus-Jacobs F,Ruggeri ZM

更新日期：1998-09-04 00:00:00

abstract：:CFTR, the protein associated with cystic fibrosis, is phosphorylated on serine residues in response to cAMP agonists. Serines 660, 737, 795, and 813 were identified as in vivo targets for phosphorylation by protein kinase A. The SPQ fluorescence assay revealed that mutagenesis of any one of these sites did not affect ...

journal_title：Cell

authors： Cheng SH,Rich DP,Marshall J,Gregory RJ,Welsh MJ,Smith AE

更新日期：1991-09-06 00:00:00

abstract：:Long chain fatty acids (LCFAs) are an important energy substrate used by cardiac myocytes and other cells, but the mechanism whereby these molecules cross the plasma membrane is poorly understood. We used an expression cloning strategy and a cDNA library from 3T3-L1 adipocytes to identify a cDNA that, when expressed i...

journal_title：Cell

authors： Schaffer JE,Lodish HF

更新日期：1994-11-04 00:00:00

abstract：:The molecular basis for membrane association of pp60v-src, the transforming protein of Rous sarcoma virus, was investigated in a cell-free system. Newly synthesized pp60v-src polypeptide, produced by in vitro translation of src mRNA, rapidly bound to plasma membranes. Binding was saturable and dependent on the presenc...

journal_title：Cell

authors： Resh MD

更新日期：1989-07-28 00:00:00

abstract：:The maternal Dorsal regulatory gradient initiates the differentiation of several tissues in the early Drosophila embryo. Whole-genome microarray assays identified as many as 40 new Dorsal target genes, which encode a broad spectrum of cell signaling proteins and transcription factors. Evidence is presented that a tiss...

journal_title：Cell

authors： Stathopoulos A,Van Drenth M,Erives A,Markstein M,Levine M

更新日期：2002-11-27 00:00:00

abstract：:Endoplasmic reticulum (ER) membrane contact sites (MCSs) mark positions where endosomes undergo fission for cargo sorting. To define the role of ER at this unique MCS, we targeted a promiscuous biotin ligase to cargo-sorting domains on endosome buds. This strategy identified the ER membrane protein TMCC1, a member of ...

journal_title：Cell

authors： Hoyer MJ,Chitwood PJ,Ebmeier CC,Striepen JF,Qi RZ,Old WM,Voeltz GK

更新日期：2018-09-20 00:00:00

abstract：:Mutants in bacterial topoisomerase (topo) IV are deficient in chromosomal partitioning. To investigate the basis of this phenotype, we examined plasmid DNA topology in conditionally lethal topo IV mutants. We found that dimeric catenated plasmids accumulated in vivo after topo IV inhibition. The catenanes were superco...

journal_title：Cell

authors： Adams DE,Shekhtman EM,Zechiedrich EL,Schmid MB,Cozzarelli NR

更新日期：1992-10-16 00:00:00

abstract：:A diverse range of ultimate chemical carcinogens inhibited the transfer of methyl groups from S-adenosylmethionine to hemimethylated DNA in a reaction catalyzed by mouse spleen methyltransferase. The formation of alkali-labile sites in DNA lessened its ability to accept methyl groups in vitro, but the methylation reac...

journal_title：Cell

authors： Wilson VL,Jones PA

更新日期：1983-01-01 00:00:00

abstract：:We have generated mice carrying a germline mutation in the tyrosine kinase catalytic domain of the trkB gene. This mutation eliminates expression of gp145trkB, a protein-tyrosine kinase that serves as the signaling receptor for two members of the nerve growth factor family of neurotrophins, brain-derived neurotrophic ...

journal_title：Cell

authors： Klein R,Smeyne RJ,Wurst W,Long LK,Auerbach BA,Joyner AL,Barbacid M

更新日期：1993-10-08 00:00:00

abstract：:Cells producing avian sarcoma virus (ASV) contain at least three virus-specific mRNAs, two of which are encoded within the 3' half of the viral genome. Each of these viral RNAs can hybridize with single-stranded DNA(cDNA5') that is complementary to a sequence of 101 nucleotides found at the 5' terminus of the ASV geno...

journal_title：Cell

authors： Cordell B,Weiss SR,Varmus HE,Bishop JM

更新日期：1978-09-01 00:00:00

abstract：:M-MuLV-specific DNA probes were used to establish the state of integration and amplification of recombinant proviral sequences in Moloney virus-induced tumors of Balb/Mo, Balb/c and 129 mice. The somatically acquired viral sequences contain both authentic M-MuLV genomes and recombinants of M-MuLV with endogenous viral...

journal_title：Cell

authors： van der Putten H,Quint W,van Raaij J,Maandag ER,Verma IM,Berns A

更新日期：1981-06-01 00:00:00

abstract：:Fluorescent proteins are commonly used to label cells across organisms, but the unmodified forms cannot control biological activities. Using GFP-binding proteins derived from Camelid antibodies, we co-opted GFP as a scaffold for inducing formation of biologically active complexes, developing a library of hybrid transc...

journal_title：Cell

authors： Tang JC,Szikra T,Kozorovitskiy Y,Teixiera M,Sabatini BL,Roska B,Cepko CL

更新日期：2013-08-15 00:00:00

abstract：:The S. pombe nuc2+ gene is required for mitotic chromosome disjunction. Its mutation arrests mitosis at the metaphase. The gene product is present in the nuclear scaffold-like fraction. The nuc2+ protein contains a domain, separated from ten 34 amino acid repeat segments, that is capable of binding AT-rich DNA in vitr...

journal_title：Cell

authors： Hirano T,Kinoshita N,Morikawa K,Yanagida M

更新日期：1990-01-26 00:00:00

abstract：:The basal ganglia (BG) are critical for adaptive motor control, but the circuit principles underlying their pathway-specific modulation of target regions are not well understood. Here, we dissect the mechanisms underlying BG direct and indirect pathway-mediated control of the mesencephalic locomotor region (MLR), a br...

journal_title：Cell

authors： Roseberry TK,Lee AM,Lalive AL,Wilbrecht L,Bonci A,Kreitzer AC

更新日期：2016-01-28 00:00:00

abstract：:A gene, bcl-3, is found on chromosome 19 adjacent to the breakpoints in the translocation t(14;19)(q32;q13.1), which occurs in some cases of chronic lymphocytic leukemia. Sequence analysis of the human bcl-3 gene predicts a protein containing seven tandem copies of the SWI6/cdc10 motif. This motif was previously ident...

journal_title：Cell

authors： Ohno H,Takimoto G,McKeithan TW

更新日期：1990-03-23 00:00:00

abstract：:The mitochondrial RNA binding proteins MRP1 and MRP2 form a heteromeric complex that functions in kinetoplastid RNA editing. In this process, MRP1/MRP2 serves as a matchmaker by binding to guide RNAs and facilitating their hybridization with cognate preedited mRNAs. To understand the mechanism by which this complex pe...

journal_title：Cell

authors： Schumacher MA,Karamooz E,Zíková A,Trantírek L,Lukes J

更新日期：2006-08-25 00:00:00

abstract：:The nucleotide sequences of the 3' termini of the DNA from four autonomous rodent parvoviruses have been determined. The terminus of each genome exists as a Y-shaped hairpin structure involving 115 or 116 nucleotides. The sequence of this region of DNA is highly conserved and shows no evidence of internal sequence het...

journal_title：Cell

authors： Astell CR,Smith M,Chow MB,Ward DC

更新日期：1979-07-01 00:00:00

abstract：:Gram-negative bacteria have an outer membrane (OM) that functions as a barrier to protect the cell from toxic compounds such as antibiotics and detergents. The OM is a highly asymmetric bilayer composed of phospholipids, glycolipids, and proteins. Assembly of this essential organelle occurs outside the cytoplasm in an...

journal_title：Cell

authors： Wu T,Malinverni J,Ruiz N,Kim S,Silhavy TJ,Kahne D

更新日期：2005-04-22 00:00:00