Rosalind Franklin and the Advent of Molecular Biology.

abstract：:The Hippo-signaling pathway is an important regulator of cellular proliferation and organ size. However, little is known about the role of this cascade in the control of cell fate. Employing a combination of lineage tracing, clonal analysis, and organoid culture approaches, we demonstrate that Hippo pathway activity i...

journal_title：Cell

authors： Yimlamai D,Christodoulou C,Galli GG,Yanger K,Pepe-Mooney B,Gurung B,Shrestha K,Cahan P,Stanger BZ,Camargo FD

更新日期：2014-06-05 00:00:00

abstract：:The Mre11/Rad50 complex has been implicated in the early steps of DNA double-strand break (DSB) repair through homologous recombination in several organisms. However, the enzymatic properties of this complex are incompatible with the generation of 3' single-stranded DNA for recombinase loading and strand exchange. In ...

journal_title：Cell

authors： Hopkins BB,Paull TT

更新日期：2008-10-17 00:00:00

abstract：:When transcription regulatory networks are compared among distantly related eukaryotes, a number of striking similarities are observed: a larger-than-expected number of genes, extensive overlapping connections, and an apparently high degree of functional redundancy. It is often assumed that the complexity of these net...

journal_title：Cell

authors： Sorrells TR,Johnson AD

更新日期：2015-05-07 00:00:00

abstract：:The general inhibition in transcriptional activity during mitosis abolishes the stress-inducible expression of the human hsp70 gene. Among the four transcription factors that bind to the human hsp70 promoter, the DNA-binding activities of three (C/EBP, GBP, and HSF1) were normal, while Sp1 showed reduced binding activ...

journal_title：Cell

authors： Martínez-Balbás MA,Dey A,Rabindran SK,Ozato K,Wu C

更新日期：1995-10-06 00:00:00

abstract：:Potassium channels embedded in cell membranes employ gates to regulate K+ current. While a specific constriction in the permeation pathway has historically been implicated in gating, recent reports suggest that the signature ion selectivity filter located in the outer membrane leaflet may be equally important. Inwardl...

journal_title：Cell

authors： Clarke OB,Caputo AT,Hill AP,Vandenberg JI,Smith BJ,Gulbis JM

更新日期：2010-06-11 00:00:00

abstract：:The cocrystal structure of human poly(A)-binding protein (PABP) has been determined at 2.6 A resolution. PABP recognizes the 3' mRNA poly(A) tail and plays critical roles in eukaryotic translation initiation and mRNA stabilization/degradation. The minimal PABP used in this study consists of the N-terminal two RRM-type...

journal_title：Cell

authors： Deo RC,Bonanno JB,Sonenberg N,Burley SK

更新日期：1999-09-17 00:00:00

abstract：:Lambda integrative recombination depends on supercoiling of the phage attachment site, attP. Using dimethylsulfate protection and indirect end-labeling, the interaction of the recombination proteins Int and IHF with supercoiled and linear attP has been studied. Supercoiling enhances the binding of Int to attP, but not...

journal_title：Cell

authors： Richet E,Abcarian P,Nash HA

更新日期：1986-09-26 00:00:00

abstract：:An important signaling pathway to the actin cytoskeleton links the Rho family GTPase Cdc42 to the actin-nucleating Arp2/3 complex through N-WASP. Nevertheless, these previously identified components are not sufficient to mediate Cdc42-induced actin polymerization in a physiological context. In this paper, we describe ...

journal_title：Cell

authors： Ho HY,Rohatgi R,Lebensohn AM,Le Ma,Li J,Gygi SP,Kirschner MW

更新日期：2004-07-23 00:00:00

abstract：:Inducer T-cell clones reactive to the p-azobenzenearsonate (arsonate) hapten possess binding sites for radioactive arsanylated proteins, which are not present on clones with other antigen specificities. Binding occurred in the absence of histocompatibility proteins. Binding was specific for the p-azobenzenearsonate ha...

journal_title：Cell

authors： Rao A,Ko WW,Faas SJ,Cantor H

更新日期：1984-04-01 00:00:00

abstract：:The cellular complexity and scale of the early liver have constrained analyses examining its emergence during organogenesis. To circumvent these issues, we analyzed 45,334 single-cell transcriptomes from embryonic day (E)7.5, when endoderm progenitors are specified, to E10.5 liver, when liver parenchymal and non-paren...

journal_title：Cell

authors： Lotto J,Drissler S,Cullum R,Wei W,Setty M,Bell EM,Boutet SC,Nowotschin S,Kuo YY,Garg V,Pe'er D,Church DM,Hadjantonakis AK,Hoodless PA

更新日期：2020-10-29 00:00:00

abstract：:Molecular chaperones assist protein folding by facilitating their "forward" folding and preventing aggregation. However, once aggregates have formed, these chaperones cannot facilitate protein disaggregation. Bacterial ClpB and its eukaryotic homolog Hsp104 are essential proteins of the heat-shock response, which have...

journal_title：Cell

authors： Lee S,Sowa ME,Watanabe YH,Sigler PB,Chiu W,Yoshida M,Tsai FT

更新日期：2003-10-17 00:00:00

abstract：:We have tested the hypothesis that DNA methylation patterns are replicated in the somatic cells of vertebrates. Using M-Hpa II, the modification enzyme from Haemophilus parainfluenzae which methylates the internal cytosine residues in the sequence 5'CCGG 3' GGCC, we methylated bacteriophage phi X174 RF DNA and the clo...

journal_title：Cell

authors： Wigler M,Levy D,Perucho M

更新日期：1981-04-01 00:00:00

abstract：:The mysterious secrets of long noncoding RNAs, often referred to as the Dark Matter of the genome, are gradually coming to light. Several recent papers dig deep to reveal surprisingly complex and diverse functions of these enigmatic molecules. ...

journal_title：Cell

authors： Nagano T,Fraser P

更新日期：2011-04-15 00:00:00

abstract：:The mechanism by which cells decide to skip mitosis to become polyploid is largely undefined. Here we used a high-content image-based screen to identify small-molecule probes that induce polyploidization of megakaryocytic leukemia cells and serve as perturbagens to help understand this process. Our study implicates fi...

journal_title：Cell

authors： Wen Q,Goldenson B,Silver SJ,Schenone M,Dancik V,Huang Z,Wang LZ,Lewis TA,An WF,Li X,Bray MA,Thiollier C,Diebold L,Gilles L,Vokes MS,Moore CB,Bliss-Moreau M,Verplank L,Tolliday NJ,Mishra R,Vemula S,Shi J,Wei L

更新日期：2012-08-03 00:00:00

abstract：:The removal of apoptotic cells by phagocytic neighbors is essential for metazoan development but remains poorly characterized. Here we report the discovery of a Drosophila phagocytosis receptor, Six-microns-under (SIMU), which is expressed in highly phagocytic cell types during development and required for efficient a...

journal_title：Cell

authors： Kurant E,Axelrod S,Leaman D,Gaul U

更新日期：2008-05-02 00:00:00

abstract：:Previous experiments have shown that mRNA translation in frog oocytes can be inhibited by the injection of a complementary antisense RNA. Here we explore the use of antisense RNAs to study the functions of localized maternal mRNAs during postfertilization development. While developmental abnormalities were observed in...

journal_title：Cell

authors： Rebagliati MR,Melton DA

更新日期：1987-02-27 00:00:00

abstract：:Cell surface growth factor receptors couple environmental cues to the regulation of cytoplasmic homeostatic processes, including autophagy, and aberrant activation of such receptors is a common feature of human malignancies. Here, we defined the molecular basis by which the epidermal growth factor receptor (EGFR) tyro...

journal_title：Cell

authors： Wei Y,Zou Z,Becker N,Anderson M,Sumpter R,Xiao G,Kinch L,Koduru P,Christudass CS,Veltri RW,Grishin NV,Peyton M,Minna J,Bhagat G,Levine B

更新日期：2013-09-12 00:00:00

abstract：:MicroRNAs interact with Argonaute proteins to guide posttranscriptional gene silencing. Eiring et al. (2010) now show that miR-328 has a second function, acting as a decoy by binding to hnRNP E2 and lifting its translational repression of an mRNA involved in myeloid cell differentiation. ...

journal_title：Cell

authors： Beitzinger M,Meister G

更新日期：2010-03-05 00:00:00

abstract：:The mechanism by which nucleosome cores are displaced and re-formed during transcription in vitro has been investigated. A nucleosome core was assembled on a short linear DNA template (227 bp) containing an SP6 RNA polymerase promoter and a nucleosome-positioning sequence. Transcription induced the translocation of th...

journal_title：Cell

authors： Studitsky VM,Clark DJ,Felsenfeld G

更新日期：1994-01-28 00:00:00

abstract：:Based on the above mechanisms of mRNA degradation, an integrated model of mRNA turnover can be proposed (Figure 1). In this model, all polyadenylated mRNAs would be degraded by the deadenylation-dependent pathway at some rate. In addition to this default pathway, another layer of complexity would come from degradation...

journal_title：Cell

authors： Beelman CA,Parker R

更新日期：1995-04-21 00:00:00

abstract：:The 10Sa RNA, encoded by the E. coli ssrA gene, appears to modulate action of some DNA-binding proteins. When ssrA is inactivated, lacZ expression from the lac operon, as well as galK from a gal operon fused to a phage lambda promoter, is reduced from that observed in bacteria wild-type for ssrA. These differences are...

journal_title：Cell

authors： Retallack DM,Friedman DI

更新日期：1995-10-20 00:00:00

abstract：:Radioactive alpha factor is degraded to discrete biologically inactive fragments by the target a cells of S. cerevisiae, but not by alpha cells which make the pheromone. The pattern of cleavage products and sequence analysis of one fragment indicated that the first scission occurred between leucine 6 and lysine 7. The...

journal_title：Cell

authors： Ciejek E,Thorner J

更新日期：1979-11-01 00:00:00

abstract：:Mucus production by goblet cells of the large intestine serves as a crucial antimicrobial protective mechanism at the interface between the eukaryotic and prokaryotic cells of the mammalian intestinal ecosystem. However, the regulatory pathways involved in goblet cell-induced mucus secretion remain largely unknown. He...

journal_title：Cell

authors： Wlodarska M,Thaiss CA,Nowarski R,Henao-Mejia J,Zhang JP,Brown EM,Frankel G,Levy M,Katz MN,Philbrick WM,Elinav E,Finlay BB,Flavell RA

更新日期：2014-02-27 00:00:00

abstract：:Stable myoblast cell lines were isolated after a brief exposure of mouse fibroblasts (10T1/2 cells) to 5-azacytidine. We show that transfection of 10T1/2 cells with DNA from these azacytidine-induced myoblasts (or from mouse C2C12 myoblasts) results in myogenic conversion of approximately 1 in 15,000 transfected colon...

journal_title：Cell

authors： Lassar AB,Paterson BM,Weintraub H

更新日期：1986-12-05 00:00:00

abstract：:Spinal muscular atrophy (SMA) is an often fatal neuromuscular disease that has been directly linked to the protein product of the Survival of Motor Neurons (SMN) gene. The SMN protein is tightly associated with a novel protein, SIP1, and together they form a complex with several spliceosomal snRNP proteins. Here we sh...

journal_title：Cell

authors： Fischer U,Liu Q,Dreyfuss G

更新日期：1997-09-19 00:00:00

abstract：:Reversible S-palmitoylation of cysteine residues critically controls transient membrane tethering of peripheral membrane proteins. Little is known about how the palmitoylation machinery governs their defined localization and function. We monitored the spatially resolved reaction dynamics and substrate specificity of t...

journal_title：Cell

authors： Rocks O,Gerauer M,Vartak N,Koch S,Huang ZP,Pechlivanis M,Kuhlmann J,Brunsveld L,Chandra A,Ellinger B,Waldmann H,Bastiaens PI

更新日期：2010-04-30 00:00:00

abstract：:Phages must be perfectly attuned to bacterial host cell physiology to ensure their optimal survival. Silpe and Bassler show that a Vibrio phage uses the host quorum-sensing pathway to trigger production of viral progeny at high cell density. ...

journal_title：Cell

authors： Maxwell KL

更新日期：2019-01-10 00:00:00

abstract：:Using insertional mutagenesis, we have isolated a "stalky" mutant in which cells destined to become spores end up as stalk cells. Similar mutants were previously observed after chemical mutagenesis, but the affected gene could not be isolated. Our mutant, like the previous ones, is in stkA. Its defect is cell-autonomo...

journal_title：Cell

authors： Chang WT,Newell PC,Gross JD

更新日期：1996-11-01 00:00:00

abstract：:An agent that blocks tumor angiogenesis, growth, and metastasis without affecting normal tissues -- whether used alone or in combination with currently approved drugs -- would change the way we treat cancer. In this issue, Fischer et al. (2007) offer compelling evidence that a monoclonal antibody against placental gro...

journal_title：Cell

authors： Jain RK,Xu L

更新日期：2007-11-02 00:00:00

abstract：:Dysregulation of splicing and alternative splicing underlies many genetic and acquired diseases. We present an overview of recent strategies and successes in modulating splicing therapeutically in clinical and preclinical contexts. Effective approaches include restoring open reading frames, influencing alternative spl...

journal_title：Cell

authors： Spitali P,Aartsma-Rus A

更新日期：2012-03-16 00:00:00