Abstract：
:Using insertional mutagenesis, we have isolated a "stalky" mutant in which cells destined to become spores end up as stalk cells. Similar mutants were previously observed after chemical mutagenesis, but the affected gene could not be isolated. Our mutant, like the previous ones, is in stkA. Its defect is cell-autonomous and not overcome by overexpressing cAMP-dependent protein kinase. stkA is strongly expressed in the prespore region of aggregates but not in the anterior prestalk zone. The mutant expresses normal levels of prespore-cell transcripts but fails to produce the spore transcript spiA. stkA encodes a predicted 99 kDa protein (STKA) with two putative C4 zinc fingers, one of which is a GATA-type finger, indicating that it may be a transcription factor. This conclusion is supported by localization of STKA in the nucleus.
journal_name
Celljournal_title
Cellauthors
Chang WT,Newell PC,Gross JDdoi
10.1016/s0092-8674(00)81367-7subject
Has Abstractpub_date
1996-11-01 00:00:00pages
471-81issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(00)81367-7journal_volume
87pub_type
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