Peroxisomes Get Loud: A Redox Antidote to Hearing Loss.

abstract：:We have performed in vitro kinetic analyses of transcription from the 5S gene promoter in order to resolve the rate-limiting events which lead to accurate transcription of the 5S RNA gene. We demonstrate that a rate-limiting intermediate can be formed during an extended incubation prior to initiation of transcription....

journal_title：Cell

authors： Bieker JJ,Martin PL,Roeder RG

更新日期：1985-01-01 00:00:00

abstract：:To determine the structural features responsible for the curvature of kinetoplast DNA, we studied 13 adenine tracts in Crithidia fasciculata kinetoplast DNA. The structures of the A tracts were analyzed by cutting the DNA with hydroxyl radical. Reactivity of hydroxyl radical toward the DNA backbone progressively decre...

journal_title：Cell

authors： Burkhoff AM,Tullius TD

更新日期：1987-03-27 00:00:00

abstract：:Factors controlling the onset and progression of extracellular amyloid diseases remain largely unknown. Central to disease etiology is the efficiency of the endoplasmic reticulum (ER) machinery that targets destabilized mutant proteins for degradation and the enhanced tendency of these variants to aggregate if secrete...

journal_title：Cell

authors： Sekijima Y,Wiseman RL,Matteson J,Hammarström P,Miller SR,Sawkar AR,Balch WE,Kelly JW

更新日期：2005-04-08 00:00:00

abstract：:Viral infection causes the host to activate an antiviral response that, in part, is dependent on mitochondrial antiviral signaling protein (MAVS) to stimulate type I interferons. Zhang et al. (2019) demonstrate that glucose-generated lactate interacts with MAVS to suppress type I interferons. This study links glucose ...

journal_title：Cell

authors： Stoolman JS,Chandel NS

更新日期：2019-06-27 00:00:00

abstract：:A nutritious diet low in calories improves the health and extends the life span of rodents. Recent studies identified a gene, SIR2, which encodes an NAD-dependent deacetylase and may mediate the effects of calorie restriction. In this review, we discuss SIR2 genes and calorie restriction in the lower organisms yeast a...

journal_title：Cell

authors： Guarente L,Picard F

更新日期：2005-02-25 00:00:00

abstract：:Mucus production by goblet cells of the large intestine serves as a crucial antimicrobial protective mechanism at the interface between the eukaryotic and prokaryotic cells of the mammalian intestinal ecosystem. However, the regulatory pathways involved in goblet cell-induced mucus secretion remain largely unknown. He...

journal_title：Cell

authors： Wlodarska M,Thaiss CA,Nowarski R,Henao-Mejia J,Zhang JP,Brown EM,Frankel G,Levy M,Katz MN,Philbrick WM,Elinav E,Finlay BB,Flavell RA

更新日期：2014-02-27 00:00:00

abstract：:Synergistic bispecific antibodies against HIV exhibit extraordinary potency and breadth of neutralization as promising candidates for treatment and prevention. ...

journal_title：Cell

authors： Montefiori DC

更新日期：2016-06-16 00:00:00

abstract：:Enteropathogenic E. coli (EPEC) belongs to a group of bacterial pathogens that induce epithelial cell actin rearrangements resulting in pedestal formation beneath adherent bacteria. This requires the secretion of specific virulence proteins needed for signal transduction and intimate adherence. EPEC interaction induce...

journal_title：Cell

authors： Kenny B,DeVinney R,Stein M,Reinscheid DJ,Frey EA,Finlay BB

更新日期：1997-11-14 00:00:00

abstract：:SecA, the peripheral subunit of E. coli preprotein translocase, alternates between a membrane inserted and a deinserted state as part of the catalytic cycle of preprotein translocation. When SecA is complexed with SecY/E and preprotein, ATP drives a profound conformational change, leading to membrane insertion of a 30...

journal_title：Cell

authors： Economou A,Wickner W

更新日期：1994-09-09 00:00:00

abstract：:The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell ...

journal_title：Cell

authors： Hanahan D,Weinberg RA

更新日期：2011-03-04 00:00:00

abstract：:The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate. The majority of t...

journal_title：Cell

authors： Zuo T,Wang L,Morrison C,Chang X,Zhang H,Li W,Liu Y,Wang Y,Liu X,Chan MW,Liu JQ,Love R,Liu CG,Godfrey V,Shen R,Huang TH,Yang T,Park BK,Wang CY,Zheng P,Liu Y

更新日期：2007-06-29 00:00:00

abstract：:Oncogenic activation of RAS genes via point mutations occurs in 20%-30% of human cancers. The development of effective RAS inhibitors has been challenging, necessitating new approaches to inhibit this oncogenic protein. Functional studies have shown that the switch region of RAS interacts with a large number of effect...

journal_title：Cell

authors： Athuluri-Divakar SK,Vasquez-Del Carpio R,Dutta K,Baker SJ,Cosenza SC,Basu I,Gupta YK,Reddy MV,Ueno L,Hart JR,Vogt PK,Mulholland D,Guha C,Aggarwal AK,Reddy EP

更新日期：2016-04-21 00:00:00

abstract：:The majority of cell lines derived by infection of murine bone marrow cells with Abelson murine leukemia virus (A-MuLV) synthesize a mu chain but no detectable light chain. Aside from this mu-only phenotype, lines that make only light chain, both chains or no immunoglobulin-related polypeptides have also been found. T...

journal_title：Cell

authors： Siden EJ,Baltimore D,Clark D,Rosenberg NE

更新日期：1979-02-01 00:00:00

abstract：:A mutation in any one of eight spoO genes of Bacillus subtilis blocks the process of spore formation at its earliest stage. To investigate how the products of the spoO genes may be involved in developmental gene expression, we fused the lacZ gene of E. coli to spoVG, a sporulation gene whose induction at the onset of ...

journal_title：Cell

authors： Zuber P,Losick R

更新日期：1983-11-01 00:00:00

abstract：:The complement system serves an important role in clearance of pathogens, immune complexes, and apoptotic cells present in the circulation. Complement fragments deposited on the particle surface serve as targets for complement receptors present on phagocytic cells. Although Kupffer cells, the liver resident macrophage...

journal_title：Cell

authors： Helmy KY,Katschke KJ Jr,Gorgani NN,Kljavin NM,Elliott JM,Diehl L,Scales SJ,Ghilardi N,van Lookeren Campagne M

更新日期：2006-03-10 00:00:00

abstract：:A key aspect of genomic medicine is to make individualized clinical decisions from personal genomes. We developed a machine-learning framework to integrate personal genomes and electronic health record (EHR) data and used this framework to study abdominal aortic aneurysm (AAA), a prevalent irreversible cardiovascular ...

journal_title：Cell

authors： Li J,Pan C,Zhang S,Spin JM,Deng A,Leung LLK,Dalman RL,Tsao PS,Snyder M

更新日期：2018-09-06 00:00:00

abstract：:The expression of the E2A transcription unit of the adenovirus E1A deletion mutant dl312 in murine embryonal carcinoma (EC) stem cells suggests that they contain an activity that will complement viral E1A. We have prepared from these cells in vitro transcription extracts that use E1A-inducible promoters more efficient...

journal_title：Cell

authors： La Thangue NB,Rigby PW

更新日期：1987-05-22 00:00:00

abstract：:Bacteria and archaea have evolved sophisticated adaptive immune systems that reply on CRISPR loci and a diverse cassette of Cas genes that are classified into three main types and at least eleven subtypes. All CRISPR-Cas immune systems operate through three main stages: acquisition, biogenesis, and interference. This ...

journal_title：Cell

authors： Carter J,Wiedenheft B

更新日期：2015-09-24 00:00:00

abstract：:Clinical trials are key to translating scientific advances into progress in cancer research and care. Confronted by developments in basic science, the landscape of clinical cancer research is rapidly evolving. Here, we review recent changes in clinical trials' design and conduct, and we forecast future directions towa...

journal_title：Cell

authors： Cescon D,Siu LL

更新日期：2017-02-09 00:00:00

abstract：:Transcription termination by bacterial RNA polymerase (RNAP) occurs at sequences coding for a GC-rich RNA hairpin followed by a U-rich tract. We used single-molecule techniques to investigate the mechanism by which three representative terminators (his, t500, and tR2) destabilize the elongation complex (EC). For his a...

journal_title：Cell

authors： Larson MH,Greenleaf WJ,Landick R,Block SM

更新日期：2008-03-21 00:00:00

abstract：:Organisms maintain the correct balance of intracellular metals primarily through metal-sensing proteins that control transport and storage of the target ion(s). Here, we reveal the basis of metal sensing and genetic control by a metalloregulatory RNA. Our data demonstrate that a previously uncharacterized orphan ribos...

journal_title：Cell

authors： Dann CE 3rd,Wakeman CA,Sieling CL,Baker SC,Irnov I,Winkler WC

更新日期：2007-09-07 00:00:00

abstract：:The mTORC1 kinase is a master growth regulator that senses many environmental cues, including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9 is an arginine sensor for the mTORC1 path...

journal_title：Cell

authors： Wyant GA,Abu-Remaileh M,Wolfson RL,Chen WW,Freinkman E,Danai LV,Vander Heiden MG,Sabatini DM

更新日期：2017-10-19 00:00:00

abstract：:Nontransformed pre-B cells were induced to differentiate in vitro along several different but predictable pathways with only dendritic cells (DC) and concanavalin A-stimulated T lymphocytes. DC-T from spleen induced secretion of only IgM, whereas DC-T from Peyer's patches induced high levels of IgA and intermediate le...

journal_title：Cell

authors： Spalding DM,Griffin JA

更新日期：1986-02-14 00:00:00

abstract：:Activins are involved in the regulation of multiple biological events, ranging from early development to pituitary function. To characterize the cellular mechanisms involved in these processes, cDNAs coding for an activin receptor were cloned from AtT20 mouse corticotropic cells by screening COS cell transfectants for...

journal_title：Cell

authors： Mathews LS,Vale WW

更新日期：1991-06-14 00:00:00

abstract：:V(D)J recombination of antigen receptor gene segments in B and T cells is mediated by the lymphoid-specific proteins RAG1 and RAG2. Now, Ji et al. (2010) demonstrate how RAG1 and RAG2 use DNA sequence specificity and modified histones within chromatin to target specific loci for V(D)J recombination at different stages...

journal_title：Cell

authors： Schlissel MS

更新日期：2010-04-30 00:00:00

abstract：:The promise of human genetics and genomics is nothing less than a fully tailored life, starting with medical treatments, diets, and preventative care all styled around a single genome. There's a lighter side as well where consumer genomics companies are helping people understand themselves and their families. Lara Sze...

journal_title：Cell

authors：

更新日期：2019-03-21 00:00:00

abstract：:Dysfunction and loss of insulin-producing pancreatic beta cells represent hallmarks of diabetes mellitus. Here, we show that mice lacking the mitogen-activated protein kinase (MAPK) p38delta display improved glucose tolerance due to enhanced insulin secretion from pancreatic beta cells. Deletion of p38delta results in...

journal_title：Cell

authors： Sumara G,Formentini I,Collins S,Sumara I,Windak R,Bodenmiller B,Ramracheya R,Caille D,Jiang H,Platt KA,Meda P,Aebersold R,Rorsman P,Ricci R

更新日期：2009-01-23 00:00:00

abstract：:The primer transcript of plasmid ColE1 extends beyond the replication origin in either of two different modes. It does or does not form a hybrid with the template DNA. When a stretch of 20 deoxyadenosine residues is inserted into the template strand downstream of the origin, more than 90% of hybridized transcripts and...

journal_title：Cell

authors： Tomizawa J,Masukata H

更新日期：1987-11-20 00:00:00

abstract：:The membrane-bound form of immunoglobulin serves as an antigen-specific receptor for B cells mediating signal transduction and antigen presentation. We have developed an assay that reconstitutes both these physiologic responses with respect to the antigen phosphorylcholine. By introducing specific mutations in the hum...

journal_title：Cell

authors： Shaw AC,Mitchell RN,Weaver YK,Campos-Torres J,Abbas AK,Leder P

更新日期：1990-10-19 00:00:00

abstract：:Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions caused more than 250 cases of Creutzfeldt-Jakob disease. More recently, transmission of bovine spongiform encephalopathy to humans caused a ...

journal_title：Cell

authors： Aguzzi A,Polymenidou M

更新日期：2004-01-23 00:00:00