Abstract:
:The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate. The majority of the cancers were mammary carcinomas in which the wild-type Foxp3 allele was inactivated and HER-2/ErbB2 was overexpressed. Foxp3 bound and repressed the HER-2/ErbB2 promoter. Deletion, functionally significant somatic mutations, and downregulation of the FOXP3 gene were commonly found in human breast cancer samples and correlated significantly with HER-2/ErbB2 overexpression, regardless of the status of HER-2 amplification. Our data demonstrate that FOXP3 is an X-linked breast cancer suppressor gene and an important regulator of the HER-2/ErbB2 oncogene.
journal_name
Celljournal_title
Cellauthors
Zuo T,Wang L,Morrison C,Chang X,Zhang H,Li W,Liu Y,Wang Y,Liu X,Chan MW,Liu JQ,Love R,Liu CG,Godfrey V,Shen R,Huang TH,Yang T,Park BK,Wang CY,Zheng P,Liu Ydoi
10.1016/j.cell.2007.04.034subject
Has Abstractpub_date
2007-06-29 00:00:00pages
1275-86issue
7eissn
0092-8674issn
1097-4172pii
S0092-8674(07)00545-4journal_volume
129pub_type
杂志文章相关文献
CELL文献大全abstract::A diverse range of ultimate chemical carcinogens inhibited the transfer of methyl groups from S-adenosylmethionine to hemimethylated DNA in a reaction catalyzed by mouse spleen methyltransferase. The formation of alkali-labile sites in DNA lessened its ability to accept methyl groups in vitro, but the methylation reac...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(83)90514-7
更新日期:1983-01-01 00:00:00
abstract::ETS transcription factors ETV2, FLI1, and ERG1 specify pluripotent stem cells into induced vascular endothelial cells (iVECs). However, iVECs are unstable and drift toward nonvascular cells. We show that human midgestation c-Kit(-) lineage-committed amniotic cells (ACs) can be reprogrammed into vascular endothelial ce...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.09.032
更新日期:2012-10-26 00:00:00
abstract::Using a defined RNA polymerase II (pol II) transcription system, we have investigated the roles of basal factors at discrete stages during the transcription cycle (e.g., initiation, promoter clearance, and transcript elongation). Abortive initiation assays revealed that TATA-binding protein, transcription factors TFII...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(94)90242-9
更新日期:1994-04-08 00:00:00
abstract::The chicken immunoglobulin light chain repertoire has been shown to be entirely derived from a single V lambda 1-J rearranged combination. The complete coding information of the lambda locus was determined: it comprises 25 V-hybridizing elements, all of which are pseudogenes, clustered in both orientations within 19 k...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90189-9
更新日期:1987-02-13 00:00:00
abstract::The proportion of BFU-E normally engaged in DNA synthesis is low in adult B6 (C57BL/6) mice of genotype Fv2rr (resistant to Friend erythroleukemia virus), as shown by 3H-thymidine or hydroxyurea "cell suicide" experiments in vivo and vitro. When bone marrow cells from these mice were subjected to a single wash in alph...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90306-8
更新日期:1981-10-01 00:00:00
abstract::The segment polarity genes engrailed and wingless are expressed in neighboring stripes of cells on opposite sides of the Drosophila parasegment boundary. Each gene is mutually required for maintenance of the other's expression; continued expression of both also requires several other segment polarity genes. We show he...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90264-d
更新日期:1992-10-02 00:00:00
abstract::Four major receptor families enable cells to respond to chemical and physical signals from their proximal environment. The ligand- and voltage-gated ion channels, G-protein-coupled receptors, nuclear hormone receptors, and receptor tyrosine kinases are all allosteric proteins that carry multiple, spatially distinct, y...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2016.08.015
更新日期:2016-08-25 00:00:00
abstract::The globin and immunoglobulin multigene families have been used to study the effect of chromosomal organization on the time of gene replication. Some of the genes are late-replicating, providing the first identification of late-replicating sequences that are not highly repetitive. One is a member of the mouse alpha-gl...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90349-0
更新日期:1984-03-01 00:00:00
abstract::K-Ras is targeted to the plasma membrane by a C-terminal membrane anchor that comprises a farnesyl-cysteine-methyl-ester and a polybasic domain. We used quantitative spatial imaging and atomistic molecular dynamics simulations to examine molecular details of K-Ras plasma membrane binding. We found that the K-Ras ancho...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.11.059
更新日期:2017-01-12 00:00:00
abstract::Using integrative genomic analysis of 360 metastatic castration-resistant prostate cancer (mCRPC) samples, we identified a novel subtype of prostate cancer typified by biallelic loss of CDK12 that is mutually exclusive with tumors driven by DNA repair deficiency, ETS fusions, and SPOP mutations. CDK12 loss is enriched...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.04.034
更新日期:2018-06-14 00:00:00
abstract::Recent studies suggest that local translation of mRNA within axons plays a key role in two aspects of growth cone navigation. One line of evidence implies a local synthesis of proteins that mediate growth cone collapse and turning in response to guidance cues; another indicates that growth cones possess the machinery ...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/s0092-8674(02)00934-0
更新日期:2002-09-06 00:00:00
abstract::Bacteria have evolved many different means of generating movement. In this issue of Cell, Shaevitz et al. (2005) describe the swimming movement of a helical bacterium called Spiroplasma. They discover that Spiroplasma propels itself by generating two temporally distinct kinks that travel the length of the bacterium. T...
journal_title:Cell
pub_type: 评论,杂志文章,评审
doi:10.1016/j.cell.2005.09.003
更新日期:2005-09-23 00:00:00
abstract::Voluntary movement is a result of signals transmitted through a communication channel that links the internal world in our minds to the physical world around us. Intention can be considered the desire to effect change on our environment, and this is contained in the signals from the brain, passed through the nervous s...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2016.02.038
更新日期:2016-03-10 00:00:00
abstract::Microbial functions in the host physiology are a result of the microbiota-host co-evolution. We show that cold exposure leads to marked shift of the microbiota composition, referred to as cold microbiota. Transplantation of the cold microbiota to germ-free mice is sufficient to increase insulin sensitivity of the host...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.11.004
更新日期:2015-12-03 00:00:00
abstract::As visualized by electron microscopy, RecA protein binds in a highly cooperative manner to single-stranded fd DNA in solutions of 0.01 M Tris (pH 7.5). The resulting nucleoprotein filament loops are 1.25 micrometers in length, have a fiber diameter of 12 nm and show an indication of a 4.5 nm repeat along the axis of t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90055-1
更新日期:1982-04-01 00:00:00
abstract::The Arabidopsis floral homeotic gene AGAMOUS (AG) is required for development of the reproductive organs (stamens and carpels). In ag mutants, the loss of AG function leads to the conversion of these organs to the perianth organs (petals and sepals). In contrast, mutations in another floral homeotic gene, APETALA2 (AP...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90271-d
更新日期:1992-10-02 00:00:00
abstract::Genetic and transcriptional maps have been constructed for the mitochondrial genome of the Ascomycete Podospora anserina. These data have been plotted on the restriction maps for Sal I, Xho I, Bam HI, Eco RI, BgI II and Hae III. We have characterized and cloned a new and unique senescent mitochondrial DNA (beta-event ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90167-2
更新日期:1982-06-01 00:00:00
abstract::The tumor suppressor gene p53 regulates multiple cellular responses to DNA damage, but the transcriptional targets that specify these responses are incompletely understood. We describe a Drosophila p53 homolog and demonstrate that it can activate transcription from a promoter containing binding sites for human p53. Do...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/S0092-8674(00)80627-3
更新日期:2000-03-31 00:00:00
abstract::S. cerevisiae inherits its vacuole by projecting vacuole-derived membrane vesicles and tubules into the bud, where they fuse to establish the daughter vacuole. This homotypic fusion event can be assayed in vitro. It requires Sec17p and Sec18p, the homologs of the mammalian alpha-SNAP and NSF, which cooperate in multip...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81084-3
更新日期:1996-04-05 00:00:00
abstract::Long pyrimidine tracts, purified from Drosophila melanogaster DNA after treatment with formic acid-diphenylamine, were used as template for E. coli RNA polymerase to produce a polynucleotide containing only purines. This polypurine RNA hybridized specifically to D. melanogaster DNA with high efficiency at low Cot valu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(75)90026-4
更新日期:1975-06-01 00:00:00
abstract::When the human beta-globin gene is transfected into Hela cells, no beta-globin RNA is detected unless the gene is linked to a viral transcription enhancer. In this paper we show that trans-acting adenovirus and herpesvirus (pseudorabies) transcriptional regulatory proteins can circumvent this enhancer requirement for ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(83)90216-7
更新日期:1983-11-01 00:00:00
abstract::Proliferating cell nuclear antigen (PCNA) is a cell cycle and growth regulated protein required for replication of SV40 DNA in vitro. Its function was investigated by comparison of the replication products synthesized in its presence or absence. In the completely reconstituted replication system that contains PCNA, DN...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(88)90493-x
更新日期:1988-04-08 00:00:00
abstract::5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB; 75 muM) inhibited only 60-75% of nuclear heterogeneous RNA (hnRNA) synthesis in HeLa cells, while the appearance of labeled cytoplasmic poly(A)-containing messenger RNA (mRNA) was reduced by approximately 95%. DRB-sensitive and resistant transcripts spanned the e...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(76)90092-1
更新日期:1976-11-01 00:00:00
abstract::O(2) is the ultimate electron acceptor for mitochondrial respiration, a process catalyzed by cytochrome c oxidase (COX). In yeast, COX subunit composition is regulated by COX5a and COX5b gene transcription in response to high and low O(2), respectively. Here we demonstrate that in mammalian cells, expression of the CO...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.01.047
更新日期:2007-04-06 00:00:00
abstract::We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81002-8
更新日期:1996-01-12 00:00:00
abstract::A novel method of affinity chromatography on insolubilized collagen-binding fragments of fibronectin was utilized to isolate a random-coil collagenous protein from culture media of mouse teratocarcinoma-derived endodermal cells. These cells also produced another collagenous protein, which did not bind to fibronectin b...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90164-7
更新日期:1982-06-01 00:00:00
abstract::We previously demonstrated that pseudogenes complementary to the small nuclear RNAs U1, U2 and U3 are dispersed and abundant in the human genome. Here we report that three pseudogenes (U1.101, U2.13 and U3.5) are flanked by perfect short direct repeats of 16 to 19 base pairs. In all three pseudogenes. the upstream dir...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90028-3
更新日期:1981-10-01 00:00:00
abstract::To assess telomerase as a cancer therapeutic target and determine adaptive mechanisms to telomerase inhibition, we modeled telomerase reactivation and subsequent extinction in T cell lymphomas arising in Atm(-/-) mice engineered with an inducible telomerase reverse transcriptase allele. Telomerase reactivation in the ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2011.12.028
更新日期:2012-02-17 00:00:00
abstract::Neuronal plasticity depends on plasma membrane Ca(2+) influx, resulting in activity-dependent gene transcription. Calmodulin (CaM) activated by Ca(2+) initiates the nuclear events, but how CaM makes its way to the nucleus has remained elusive. Ma et al. now show that CaMKIIγ transports CaM from cell surface Ca(2+) cha...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2014.09.023
更新日期:2014-10-09 00:00:00
abstract::Sensory transduction in E. coli consists of two phases, excitation and adaptation, both of which involve the methyl-accepting chemotaxis proteins (MCPs). These molecules relay transmembrane signals and are reversibly methylated during adaptation of E. coli to environmental stimuli. Each MCP contains multiple sites of ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90438-x
更新日期:1982-07-01 00:00:00