Abstract：
:We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core.
journal_name
Celljournal_title
Cellauthors
Leahy DJ,Aukhil I,Erickson HPdoi
10.1016/s0092-8674(00)81002-8subject
Has Abstractpub_date
1996-01-12 00:00:00pages
155-64issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(00)81002-8journal_volume
84pub_type
杂志文章相关文献
CELL文献大全abstract：:Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro; however, the role of RBC dehydration in protection against malaria in vivo is unknown. Most cases of hereditary xer...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.02.047
更新日期：2018-04-05 00:00:00
abstract：:Portions of the nascent chain are exposed to the lumen, the cytosol, or neither at different stages during the cotranslational integration of a protein into the ER membrane, as shown by compartment-specific collisional quenching of fluorophores incorporated into the polypeptide. The opening or closing of each end of t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80311-6
更新日期：1997-07-11 00:00:00
abstract：:A clone encoding PrP 27-30, the major protein in purified preparations of scrapie agent, was selected from a scrapie-infected hamster brain cDNA library by oligonucleotide probes corresponding to the N terminus of the protein. Southern blotting with PrP cDNA revealed a single gene with the same restriction patterns in...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90333-2
更新日期：1985-04-01 00:00:00
abstract：:When treated with the synthetic glucocorticoid dexamethasone, HT1080 human fibrosarcoma cells show changes in morphology, adhesion, and the extracellular matrix. Dexamethasone treatment results in a tenfold increase in the rate of fibronectin biosynthesis in HT1080 cells and a twofold increase in untransformed, normal...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90357-4
更新日期：1983-05-01 00:00:00
abstract：:Can a heterotrophic organism be evolved to synthesize biomass from CO2 directly? So far, non-native carbon fixation in which biomass precursors are synthesized solely from CO2 has remained an elusive grand challenge. Here, we demonstrate how a combination of rational metabolic rewiring, recombinant expression, and lab...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.05.064
更新日期：2016-06-30 00:00:00
abstract：:Activation of the adenylyl cyclase signaling pathway elicits the induction of genes via activators binding to cAMP-responsive elements (CREs). Nuclear factor CRE modulator (CREM) is activated by PKA-mediated phosphorylation on a serine at position 117. We show that Ser-117 is also phosphorylated by the mitogen-activat...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(94)90402-2
更新日期：1994-10-07 00:00:00
abstract：:Clarification of the information processing system in bacterial sensing has been obtained by studying mutants that lack the capacity to modify receptors covalently. The remaining part of the system is able to receive signals from the receptor, to respond with partial adaptation, and to exhibit a chemotactic response. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90125-4
更新日期：1985-09-01 00:00:00
abstract：:We describe a monoclonal antibody (anti-FC-1) that inhibits the attachment of chicken embryo fibroblasts to artificial substrates. In the immunofluorescence, anti-FC-1 also stained the focal contacts of the fibroblasts, organelles suggested to be involved in cell-substrate adhesion. This antibody was absorbed on the s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90322-1
更新日期：1982-12-01 00:00:00
abstract：:Highly virulent influenza virus infection results in excessive cytokine production, recruitment of leukocytes, and immune-mediated pulmonary injury. Teijaro et al. (2011) now demonstrate that sphingosine-1-phosphate receptor 1 ligands suppress all features of flu-inflicted pathological inflammation and place the endot...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2011.08.027
更新日期：2011-09-16 00:00:00
abstract：:Fragile X syndrome, a common form of inherited intellectual disability, is caused by loss of the fragile X mental retardation protein FMRP. FMRP is present predominantly in the cytoplasm, where it regulates translation of proteins that are important for synaptic function. We identify FMRP as a chromatin-binding protei...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.03.040
更新日期：2014-05-08 00:00:00
abstract：:Senescence in Podospora anserina has long been shown to be under cytoplasmic control. Comparison of DNAs isolated from young and senescent cultures made it possible to detect the presence, in senescent cultures only, of a specific DNA (SEN-DNA). This DNA consists of repeated sequences arranged in a multimeric set of c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90126-9
更新日期：1980-08-01 00:00:00
abstract：:We chemically synthesized 20 peptides corresponding to 75% of the HA1 molecule of the influenza virus. Antibodies to the majority (18) of these peptides were capable of reacting with the hemagglutinin molecule. These 18 peptides are not confined to the known antigenic determinants of the hemagglutinin molecule, but ra...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90202-1
更新日期：1982-03-01 00:00:00
abstract：:Secreted proteins of the Wnt family have profound organizing roles during animal development and are transduced via the activities of the Frizzled (Fz) class of transmembrane receptors and the TCF/LEF/Pangolin class of transcription factors. beta-catenins, including Drosophila Armadillo (Arm), link activation of Fz at...
journal_title：Cell
pub_type： 杂志文章,收录出版
doi：10.1016/s0092-8674(02)01037-1
更新日期：2002-10-18 00:00:00
abstract：:Many organisms expand the information content of their genome through enzymatic methylation of cytosine residues. Here we report the 2.8 A crystal structure of a bacterial DNA (cytosine-5)-methyltransferase (DCMtase), M. HaeIII, bound covalently to DNA. In this complex, the substrate cytosine is extruded from the DNA ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90060-8
更新日期：1995-07-14 00:00:00
abstract：:The erythropoietin receptor (EpoR) is essential for production of red blood cells; a principal function of EpoR is to rescue committed erythroid progenitors from apoptosis. Stat5 is rapidly activated following EpoR stimulation, but its function in erythropoiesis has been unclear since adult Stat5a-/-5b-/- mice have no...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81013-2
更新日期：1999-07-23 00:00:00
abstract：:The association of histone modification changes with autism spectrum disorder (ASD) has not been systematically examined. We conducted a histone acetylome-wide association study (HAWAS) by performing H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq) on 257 postmortem samples from ASD and matched control brai...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.10.031
更新日期：2016-11-17 00:00:00
abstract：:Polycomb group (PcG) proteins form large multimeric complexes (PcG bodies) which are involved in the stable repression of gene expression. The human PcG protein, Pc2, has been shown to recruit the transcriptional corepressor, CtBP, to PcG bodies. We show that CtBP is sumoylated at a single lysine. In vitro, CtBP sumoy...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00159-4
更新日期：2003-04-04 00:00:00
abstract：:In thymic epithelial cells, the protein Aire (autoimmune regulator) induces the ectopic expression of hundreds of peripheral tissue antigens, thus enlarging the repertoire of antigens available for the induction of central T cell tolerance. By analyzing Aire's interacting partners, Abramson et al. (2010) shed new ligh...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2009.12.036
更新日期：2010-01-08 00:00:00
abstract：:Exit from mitosis must not occur prior to partitioning of chromosomes between daughter cells. We find that the GTP binding protein Tem1, a regulator of mitotic exit, is present on the spindle pole body that migrates into the bud during S phase and mitosis. Tem1's exchange factor, Lte1, localizes to the bud. Thus, Tem1...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)00007-6
更新日期：2000-07-07 00:00:00
abstract：:Vertebrate Hoxd genes are sequentially activated during the morphogenesis and pattern formation of the limb. Using the approach of gene disruption via homologous recombination in embryonic stem cells, we have assessed the function of the last gene of the complex, Hoxd-13. Mutant mice displayed skeletal alterations alo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90378-4
更新日期：1993-11-05 00:00:00
abstract：:In Saccharomyces cerevisiae, known histone acetylation sites regulating gene activity are located in the N-terminal tails protruding from the nucleosome core. We report lysine 56 in histone H3 as a novel acetylation site that is located in the globular domain, where it extends toward the DNA major groove at the entry-...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.03.011
更新日期：2005-05-06 00:00:00
abstract：:p120-catenin regulates cell-cell adhesion by controlling cell surface retention of cadherin. In this issue, Ishiyama et al. (2010) present the first crystal structure of p120 in complex with cadherin, revealing molecular details of the functional interface and providing sophisticated new tools for dissecting p120's ro...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2010.03.022
更新日期：2010-04-02 00:00:00
abstract：:The brightness of our visual environment varies tremendously from day to night. In this issue of Cell, Milner and Do describe how the population of retinal neurons responsible for entrainment of the brain's circadian clock cooperate to encode irradiance across a wide range of ambient-light intensities. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2017.10.028
更新日期：2017-11-02 00:00:00
abstract：:ABCA1, an ATP-binding cassette (ABC) subfamily A exporter, mediates the cellular efflux of phospholipids and cholesterol to the extracellular acceptor apolipoprotein A-I (apoA-I) for generation of nascent high-density lipoprotein (HDL). Mutations of human ABCA1 are associated with Tangier disease and familial HDL defi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.05.020
更新日期：2017-06-15 00:00:00
abstract：:Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2 comp...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.04.026
更新日期：2020-05-28 00:00:00
abstract：:Tyrosyl phosphorylation is implicated in the mechanism of insulin action. Mutation of the beta-subunit of the insulin receptor by substitution of tyrosyl residue 960 with phenylalanine had no effect on insulin-stimulated autophosphorylation or phosphotransferase activity of the purified receptor. However, unlike the n...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(88)80008-4
更新日期：1988-08-26 00:00:00
abstract：:The heterotrimeric Sec61p complex is a major component of the protein-conducting channel of the endoplasmic reticulum (ER) membrane, associating with either ribosomes or the Sec62/63 complex to perform co- and posttranslational transport, respectively. We show by electron microscopy that purified mammalian and yeast S...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81391-4
更新日期：1996-11-15 00:00:00
abstract：:Transfer of human chromosome 11, which contains the myoD locus, from primary fibroblasts into 10T1/2 cells results in activation of myoD. In contrast, hybrids that retain human chromosome 11 and additional human chromosomes fail to activate myoD. We show that human chromosome 4 inhibits myoD activation. myoD enhancer/...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90033-0
更新日期：1995-08-25 00:00:00
abstract：:By chromosome walking in the major histocompatibility complex (MHC) of the BALB/c mouse, we have linked the K region to the I region at the molecular level. Forty-nine overlapping cosmid clones define a stretch of about 600 kb of DNA containing 2 class I and 7 class II genes. Eleven independent recombination events we...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90012-7
更新日期：1986-03-28 00:00:00
abstract：:The orderly reduction in chromosome number that occurs during meiosis depends on two aspects of chromosome behavior specific to the first meiotic division. These are the retention of cohesion between sister centromeres and their attachment to microtubules that extend to the same pole (monopolar attachment). By deletin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)00217-8
更新日期：2000-12-22 00:00:00
