Abstract：
:In Saccharomyces cerevisiae, known histone acetylation sites regulating gene activity are located in the N-terminal tails protruding from the nucleosome core. We report lysine 56 in histone H3 as a novel acetylation site that is located in the globular domain, where it extends toward the DNA major groove at the entry-exit points of the DNA superhelix as it wraps around the nucleosome. We show that K56 acetylation is enriched preferentially at certain active genes, such as those coding for histones. SPT10, a putative acetyltransferase, is required for cell cycle-specific K56 acetylation at histone genes. This allows recruitment of the nucleosome remodeling factor Snf5 and subsequent transcription. These findings indicate that histone H3 K56 acetylation at the entry-exit gate enables recruitment of the SWI/SNF nucleosome remodeling complex and so regulates gene activity.
journal_name
Celljournal_title
Cellauthors
Xu F,Zhang K,Grunstein Mdoi
10.1016/j.cell.2005.03.011subject
Has Abstractpub_date
2005-05-06 00:00:00pages
375-85issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(05)00283-7journal_volume
121pub_type
杂志文章相关文献
CELL文献大全abstract：:Autosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telomerase. To examine the dosage effect of telomerase, we generated a line of mTR+/- mice on the CAST/EiJ background, which has short telomeres. Interbreeding of heterozygotes resulted in progressive telomere shortening, indicating...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.11.020
更新日期：2005-12-16 00:00:00
abstract：:The promise of human genetics and genomics is nothing less than a fully tailored life, starting with medical treatments, diets, and preventative care all styled around a single genome. There's a lighter side as well where consumer genomics companies are helping people understand themselves and their families. Lara Sze...
journal_title：Cell
pub_type： 面试
doi：10.1016/j.cell.2019.03.002
更新日期：2019-03-21 00:00:00
abstract：:Interactions between similar but not identical (homeologous) DNA sequences play an important biological role in the evolution of genes and genomes. To gain insight into the underlying molecular mechanism(s) of genetic recombination, we have studied inter- and intramolecular homeologous recombination in S. cerevisiae d...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90434-e
更新日期：1992-08-21 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death worldwide. We report in an emphysema model of mice chronically exposed to tobacco smoke that pulmonary vascular dysfunction, vascular remodeling, and pulmonary hypertension (PH) precede development of alveolar destruction. We provid...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.08.035
更新日期：2011-10-14 00:00:00
abstract：:We report the discovery of a short-lived chaperone that is required for the correct maturation of the eukaryotic 20S proteasome and is destroyed at a specific stage of the assembly process. The S. cerevisiae Ump1p protein is a component of proteasome precursor complexes containing unprocessed beta subunits but is not ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80942-3
更新日期：1998-02-20 00:00:00
abstract：:Treatment of the kidney epithelial cell line MDCK with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a large increase in the permeability of tight junctions within 2-4 hr. This change in transepithelial permeability is accompanied by alterations in cell morphology that include the opening of ti...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90274-9
更新日期：1981-01-01 00:00:00
abstract：:Reversible S-palmitoylation of cysteine residues critically controls transient membrane tethering of peripheral membrane proteins. Little is known about how the palmitoylation machinery governs their defined localization and function. We monitored the spatially resolved reaction dynamics and substrate specificity of t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.04.007
更新日期：2010-04-30 00:00:00
abstract：:Reactivation of human cytomegalovirus (HCMV) results in severe disease in AIDS patients and immunocompromised patients receiving blood transfusions or organ or bone marrow grafts. Although the site of HCMV latency is unknown, blood cells have been implicated as a viral reservoir. In this study, we demonstrate HCMV rea...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)80014-3
更新日期：1997-10-03 00:00:00
abstract：:We have developed an in vitro system utilizing yeast cell-free extracts to catalyze recombination events between homologous plasmids containing different mutant alleles of the Tet or ARG4 genes. The reaction increased the frequency of Tcr or Arg+ transformants (recombinants) from 2 X 10(-6) to 1-3 X 10(-3). Linearizin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90113-7
更新日期：1983-12-01 00:00:00
abstract：:The full-length cDNA for a transcriptional activator, DBP, that binds to the D site of the albumin promoter has been cloned. DBP belongs to a family of related transcription factors including Fos, Jun, CREB, and C/EBP, which share a conserved basic domain. However, unlike most other members of this family, DBP does no...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90808-r
更新日期：1990-04-20 00:00:00
abstract：:The differentiation of follicular dendritic cells (FDC) is essential to the remarkable microanatomic plasticity of lymphoid follicles. Here we show that FDC arise from ubiquitous perivascular precursors (preFDC) expressing platelet-derived growth factor receptor β (PDGFRβ). PDGFRβ-Cre-driven reporter gene recombinatio...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.05.032
更新日期：2012-07-06 00:00:00
abstract：:Recombinant DNAs containing the E. coli plasmid pSC101 and mouse cell (La9) mitochondrial DNA (mtDNA) were formed in vitro via ligation of DNA fragments from limit EcoRI endonuclease digests and were used to transform E. coli K12. Four structurally different recombinant plasmid DNAs from transformed clones were charac...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90202-6
更新日期：1976-04-01 00:00:00
abstract：:Iron is ubiquitous in the environment and in biology. The study of iron biology focuses on physiology and homeostasis-understanding how cells and organisms regulate their iron content, how diverse tissues orchestrate iron allocation, and how dysregulated iron homeostasis leads to common hematological, metabolic, and n...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/s0092-8674(04)00343-5
更新日期：2004-04-30 00:00:00
abstract：:Aging has been associated with a progressive decline of proteostasis, but how this process affects proteome composition remains largely unexplored. Here, we profiled more than 5,000 proteins along the lifespan of the nematode C. elegans. We find that one-third of proteins change in abundance at least 2-fold during agi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.03.032
更新日期：2015-05-07 00:00:00
abstract：:Polyadenylation of mRNA precursors by poly(A) polymerase depends on a specificity factor, CPF, recognizing the polyadenylation signal AAUAAA. This paper describes an apparently novel poly(A)-binding protein that acts as a second specificity factor, mediating the recognition of the growing poly(A) tail. A transition fr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90119-j
更新日期：1991-08-23 00:00:00
abstract：:Neural inputs from internal organs are essential for normal autonomic function. The vagus nerve is a key body-brain connection that monitors the digestive, cardiovascular, and respiratory systems. Within the gastrointestinal tract, vagal sensory neurons detect gut hormones and organ distension. Here, we investigate th...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.05.011
更新日期：2016-06-30 00:00:00
abstract：:The human immunodeficiency virus, the lentivirus that causes AIDS, is responsible for the most prevalent epidemic in the history of mankind. Here in this Timeline, we have attempted to illustrate a short history of HIV-1, from its identification in landmark papers published by Robert Gallo, Myron Essex, and Luc Montag...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.09.004
更新日期：2020-10-15 00:00:00
abstract：:The neurofibromatosis type 1 (NF1) protein contains a region of significant sequence similarity to ras p21 GTPase-activating protein (GAP) and the yeast IRA1 gene product. A fragment of NF1 cDNA encoding the GAP-related domain (NF1 GRD) was expressed, immunoaffinity purified, and assayed for effects on N-ras p21 GTPas...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90150-d
更新日期：1990-11-16 00:00:00
abstract：:We have prepared three monoclonal antibodies against human epidermal keratins. These antibodies were highly specific for keratins and, in combination, recognized all major epidermal keratins of several mammalian species. We have used these antibodies to study the tissue distribution of epidermis-related keratins. In v...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90234-3
更新日期：1982-09-01 00:00:00
abstract：:Synapse formation requires changes in cell morphology and the upregulation and localization of synaptic proteins. In the cerebellum, mossy fibers undergo extensive remodeling as they contact several granule cells and form complex, multisynaptic glomerular rosettes. Here we show that granule cells secrete factors that ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80689-3
更新日期：2000-03-03 00:00:00
abstract：:Retrotransposons have shaped eukaryotic genomes for millions of years. To analyze the consequences of human L1 retrotransposition, we developed a genetic system to recover many new L1 insertions in somatic cells. Forty-two de novo integrants were recovered that faithfully mimic many aspects of L1s that accumulated sin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)00839-5
更新日期：2002-08-09 00:00:00
abstract：:Cyclic dinucleotides (CDNs) play central roles in bacterial pathogenesis and innate immunity. The mammalian enzyme cGAS synthesizes a unique cyclic dinucleotide (cGAMP) containing a 2'-5' phosphodiester linkage essential for optimal immune stimulation, but the molecular basis for linkage specificity is unknown. Here, ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.07.028
更新日期：2014-08-28 00:00:00
abstract：:Chemical cross-linking and DNA sequencing have revealed regions of intra-chromosomal interaction, referred to as topologically associating domains (TADs), interspersed with regions of little or no interaction, in interphase nuclei. We find that TADs and the regions between them correspond with the bands and interbands...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.10.026
更新日期：2015-11-05 00:00:00
abstract：:The DNA-binding region of Myb consists of three imperfect tandem repeats (R1, R2, and R3). We have determined the solution structure of a specific DNA complex of the minimum DNA-binding domain (R2R3) by heteronuclear multidimensional NMR. Both R2 and R3 contain three helices, and the third helix in each is found to be...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(94)90549-5
更新日期：1994-11-18 00:00:00
abstract：:Rat liver interphase chromosomes have telomeres 20-100 kb in length. Micrococcal nuclease digestion of nuclei cleaves telomeres with a uniform 157 bp periodicity, producing soluble particles that sediment in sucrose gradients exactly like oligonucleosomes. The monomeric telomere particles comigrate with nucleosome cor...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90256-p
更新日期：1993-05-21 00:00:00
abstract：:Rho family GTPases are thought to regulate actin-dependent processes, but their functions in vivo are still poorly understood. We have investigated the function of a new, widely expressed Rho family member in C. elegans by analyzing mutations in the endogenous gene. Activated and null alleles all inhibit cell migratio...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80353-0
更新日期：1997-09-05 00:00:00
abstract：:The sites at which topoisomerase I interacts with the transcriptionally active ribosomal chromatin of Xenopus oocytes were mapped by treating oocyte nuclei first with camptothecin to stabilize topoisomerase I-rDNA reaction intermediates, and then with SDS to resolve these adducts as protein-linked nicks in the DNA. St...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90471-0
更新日期：1988-02-26 00:00:00
abstract：:Evidence is now mounting that liquid-liquid phase separation (LLPS) underlies the formation of membraneless compartments in cells. This realization has motivated major efforts to delineate the function of such biomolecular condensates in normal cells and their roles in contexts ranging from development to age-related ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2018.12.035
更新日期：2019-01-24 00:00:00
abstract：:A recent report proposed a function of the ubiquitin conjugation factors Rad6 and Rad18 comparable to the bacterial SOS response, controlling damage-induced transcriptional activation and contributing to checkpoint signaling. The relevant ubiquitylation target was identified as budding yeast Rad17, a subunit of the PC...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.04.039
更新日期：2010-06-11 00:00:00
abstract：:An approach to identify backbone conformational changes underlying nicotinic acetylcholine receptor (nAChR) gating was developed. Specific backbone peptide bonds were replaced with an ester, which disrupts backbone hydrogen bonds at the site of mutation. At a conserved proline residue (alphaPro221) in the first transm...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80962-9
更新日期：1999-01-08 00:00:00
