Abstract：
:Rho family GTPases are thought to regulate actin-dependent processes, but their functions in vivo are still poorly understood. We have investigated the function of a new, widely expressed Rho family member in C. elegans by analyzing mutations in the endogenous gene. Activated and null alleles all inhibit cell migration, demonstrating that this protein is required for cell migration in vivo. Only a small subset of the migrations inhibited by activating mutations are inhibited by null mutations, suggesting that considerable functional redundancy exists within this system. Our findings support this conclusion and show that mig-2 functions redundantly with another pathway to regulate nuclear migration. Surprisingly, activated alleles also cause misguided axon growth, suggesting that Rho family GTPases may couple guidance cues to process outgrowth.
journal_name
Celljournal_title
Cellauthors
Zipkin ID,Kindt RM,Kenyon CJdoi
10.1016/s0092-8674(00)80353-0subject
Has Abstractpub_date
1997-09-05 00:00:00pages
883-94issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(00)80353-0journal_volume
90pub_type
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