It takes a PHD to read the histone code.


:The pattern of histone modifications, called the histone code, influences transitions between chromatin states and the regulation of transcriptional activity. Four recent papers describe how plant homeodomain (PHD) finger proteins read part of this code. The PHD finger may promote both gene expression and repression through interactions with trimethylated lysine 4 on histone 3 (H3K4), a universal modification at the beginning of active genes.






Mellor J




Has Abstract


2006-07-14 00:00:00
















  • Muscle fiber pattern is independent of cell lineage in postnatal rodent development.

    abstract::Muscle fibers specialized for fast or slow contraction are arrayed in characteristic patterns within developing limbs. Clones of myoblasts analyzed in vitro express fast and slow myosin isoforms typical of the muscle from which they derive. As a result, it has been suggested that distinct myoblast lineages generate an...


    pub_type: 杂志文章


    authors: Hughes SM,Blau HM

    更新日期:1992-02-21 00:00:00

  • Metabolism, cell surface organization, and disease.

    abstract::Genetic information flows from DNA to macromolecular structures-the dominant force in the molecular organization of life. However, recent work suggests that metabolite availability to the hexosamine and Golgi N-glycosylation pathways exerts control over the assembly of macromolecular complexes on the cell surface and,...


    pub_type: 杂志文章,评审


    authors: Dennis JW,Nabi IR,Demetriou M

    更新日期:2009-12-24 00:00:00

  • Alleles of the APC gene: an attenuated form of familial polyposis.

    abstract::An attenuated form of familial adenomatous polyposis coli, AAPC, causes relatively few colonic polyps, but still carries a significant risk of colon cancer. The mutant alleles responsible for this attenuated phenotype have been mapped in several families to the adenomatous polyposis coli (APC) locus on human chromosom...


    pub_type: 杂志文章


    authors: Spirio L,Olschwang S,Groden J,Robertson M,Samowitz W,Joslyn G,Gelbert L,Thliveris A,Carlson M,Otterud B

    更新日期:1993-12-03 00:00:00

  • Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85.

    abstract::We have shown that covalent conjugation of ubiquitin to proteins is temperature-sensitive in the mouse cell cycle mutant ts85 due to a specifically thermolabile ubiquitin-activating enzyme (accompanying paper). We show here that degradation of short-lived proteins is also temperature sensitive in ts85 , in contrast to...


    pub_type: 杂志文章


    authors: Ciechanover A,Finley D,Varshavsky A

    更新日期:1984-05-01 00:00:00

  • Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment.

    abstract::Chemotherapy results in a frequent yet poorly understood syndrome of long-term neurological deficits. Neural precursor cell dysfunction and white matter dysfunction are thought to contribute to this debilitating syndrome. Here, we demonstrate persistent depletion of oligodendrocyte lineage cells in humans who received...


    pub_type: 杂志文章


    authors: Gibson EM,Nagaraja S,Ocampo A,Tam LT,Wood LS,Pallegar PN,Greene JJ,Geraghty AC,Goldstein AK,Ni L,Woo PJ,Barres BA,Liddelow S,Vogel H,Monje M

    更新日期:2019-01-10 00:00:00

  • Sensory Neurons that Detect Stretch and Nutrients in the Digestive System.

    abstract::Neural inputs from internal organs are essential for normal autonomic function. The vagus nerve is a key body-brain connection that monitors the digestive, cardiovascular, and respiratory systems. Within the gastrointestinal tract, vagal sensory neurons detect gut hormones and organ distension. Here, we investigate th...


    pub_type: 杂志文章


    authors: Williams EK,Chang RB,Strochlic DE,Umans BD,Lowell BB,Liberles SD

    更新日期:2016-06-30 00:00:00

  • A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro.

    abstract::Erythroid Krüppel-like factor (EKLF) is necessary for stage-specific expression of the human beta-globin gene. We show that EKLF requires a SWI/SNF-related chromatin remodeling complex, EKLF coactivator-remodeling complex 1 (E-RC1), to generate a DNase I hypersensitive, transcriptionally active beta-globin promoter on...


    pub_type: 杂志文章


    authors: Armstrong JA,Bieker JJ,Emerson BM

    更新日期:1998-10-02 00:00:00

  • Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition.

    abstract::The double-stranded RNA-activated protein kinase (PKR) was originally identified as a sensor of virus infection, but its function in the brain remains unknown. Here, we report that the lack of PKR enhances learning and memory in several behavioral tasks while increasing network excitability. In addition, loss of PKR i...


    pub_type: 杂志文章


    authors: Zhu PJ,Huang W,Kalikulov D,Yoo JW,Placzek AN,Stoica L,Zhou H,Bell JC,Friedlander MJ,Krnjević K,Noebels JL,Costa-Mattioli M

    更新日期:2011-12-09 00:00:00

  • COP1, an Arabidopsis regulatory gene, encodes a protein with both a zinc-binding motif and a G beta homologous domain.

    abstract::Plant seedling development is capable of following 1 of 2 distinct morphogenic pathways: skotomorphogenesis in darkness and photomorphogenesis in light. Dark-grown Arabidopsis seedlings with recessive mutations at the constitutively photomorphogenic (COP1) locus indicate that the wild-type COP1 protein represses photo...


    pub_type: 杂志文章


    authors: Deng XW,Matsui M,Wei N,Wagner D,Chu AM,Feldmann KA,Quail PH

    更新日期:1992-11-27 00:00:00

  • Are mitochondrial structural genes selectively amplified during senescence in Podospora anserina?

    abstract::Genetic and transcriptional maps have been constructed for the mitochondrial genome of the Ascomycete Podospora anserina. These data have been plotted on the restriction maps for Sal I, Xho I, Bam HI, Eco RI, BgI II and Hae III. We have characterized and cloned a new and unique senescent mitochondrial DNA (beta-event ...


    pub_type: 杂志文章


    authors: Wright RM,Horrum MA,Cummings DJ

    更新日期:1982-06-01 00:00:00

  • Cell death: a new Par-4 the TRAIL.

    abstract::The protein Par-4 acts in the cytoplasm to trigger cell death signaling via caspase activation and the mitochondrial release of cytochrome c. Burikhanov et al. (2009) now provide surprising evidence that Par-4 can also promote apoptosis from outside the cell, after its secretion in response to endoplasmic reticulum st...


    pub_type: 评论,杂志文章


    authors: Hart LS,El-Deiry WS

    更新日期:2009-07-23 00:00:00

  • Tube morphogenesis: making and shaping biological tubes.

    abstract::Many organs are composed of epithelial tubes that transport vital fluids. Such tubular organs develop in many different ways and generate tubes of widely varying sizes and structures, but always with the apical epithelial surface lining the lumen. We describe recent progress in several diverse cell culture and genetic...


    pub_type: 杂志文章,评审


    authors: Lubarsky B,Krasnow MA

    更新日期:2003-01-10 00:00:00

  • Giving meaning to movement.

    abstract::A growing body of evidence indicates that plant transcription factors move between cells. A recent paper by Nakajima et al. (2001) shows that movement of the SHORTROOT protein provides a mechanism for signaling positional information between cell layers of the root. ...


    pub_type: 杂志文章,评审


    authors: Barton MK

    更新日期:2001-10-19 00:00:00

  • Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals.

    abstract::Proteotypes, like genotypes, have been found to vary between individuals in several studies, but consistent molecular functional traits across studies remain to be quantified. In a meta-analysis of 11 proteomics datasets from humans and mice, we use co-variation of proteins in known functional modules across datasets ...


    pub_type: 杂志文章


    authors: Romanov N,Kuhn M,Aebersold R,Ori A,Beck M,Bork P

    更新日期:2019-05-16 00:00:00

  • A 450 kb transgene displays properties of the mammalian X-inactivation center.

    abstract::X inactivation results in inactivation of one X chromosome to compensate for gene dosage differences between mammalian females and males. It requires the X-inactivation center (Xic) and Xist in cis. We report that introducing 450 kb of murine Xic/Xist sequences onto autosomes activates female dosage compensation in ma...


    pub_type: 杂志文章


    authors: Lee JT,Strauss WM,Dausman JA,Jaenisch R

    更新日期:1996-07-12 00:00:00

  • Tumor Evolution: A Problem of Histocompatibility.

    abstract::In this issue of Cell, two articles show that tumor-specific changes in HLA-mediated antigen presentation affect tumor immunogenicity and may play a role in shaping cancer cell survival. ...


    pub_type: 评论,杂志文章


    authors: Vokes NI,Van Allen EM

    更新日期:2017-11-30 00:00:00

  • The pro region of BPTI facilitates folding.

    abstract::The in vitro folding pathway of bovine pancreatic trypsin inhibitor (BPTI) has been described previously in terms of the disulfide-bonded intermediates that accumulate during folding of the protein. Folding is slow, occurring in hours at pH 7.3, 25 degrees C. In addition, approximately half of the BPTI molecules becom...


    pub_type: 杂志文章


    authors: Weissman JS,Kim PS

    更新日期:1992-11-27 00:00:00

  • The regulatory light chain of nonmuscle myosin is encoded by spaghetti-squash, a gene required for cytokinesis in Drosophila.

    abstract::Two independent approaches to understanding the molecular mechanism of cytokinesis have converged on the gene spaghetti-squash (sqh). A genetic screen for mitotic mutants identified sqh1, a mutation that disrupts cytokinesis, which was then cloned by transposon tagging. Independently, the gene that encodes the regulat...


    pub_type: 杂志文章


    authors: Karess RE,Chang XJ,Edwards KA,Kulkarni S,Aguilera I,Kiehart DP

    更新日期:1991-06-28 00:00:00

  • New surface component of fibroblast's focal contacts identified by a monoclonal antibody.

    abstract::We describe a monoclonal antibody (anti-FC-1) that inhibits the attachment of chicken embryo fibroblasts to artificial substrates. In the immunofluorescence, anti-FC-1 also stained the focal contacts of the fibroblasts, organelles suggested to be involved in cell-substrate adhesion. This antibody was absorbed on the s...


    pub_type: 杂志文章


    authors: Oesch B,Birchmeier W

    更新日期:1982-12-01 00:00:00

  • SnapShot: Functions of Tubulin Posttranslational Modifications.

    abstract::Post-translational modification of tubulin offers a mechanism for functional diversification of microtubules and regulation in a variety of physiological contexts. This SnapShot recaps the current state of understanding of tubulin posttranslational modifications and their functions in the regulation of biological proc...


    pub_type: 杂志文章


    authors: Magiera MM,Singh P,Janke C

    更新日期:2018-05-31 00:00:00

  • Sequence of interrupted and uninterrupted mRNAs and cloned DNA coding for the two overlapping nonstructural proteins of influenza virus.

    abstract::We have obtained the complete sequence of cloned full-length DNA (NS DNA) derived from influenza virus gene 8, which codes for two unique polypeptides, NS1 and NS2, and the sequence of the NS2 mRNA. Previously we showed that the mRNA for NS1 (approximately 860 nucleotides) is colinear with the viral RNA and maps from ...


    pub_type: 杂志文章


    authors: Lamb RA,Lai CJ

    更新日期:1980-09-01 00:00:00

  • Bacterial bioluminescence: isolation and genetic analysis of functions from Vibrio fischeri.

    abstract::Recombinant E. coli that produce light were found in a clone library of hybrid plasmids containing DNA from the marine bacterium Vibrio fischeri. All luminescent clones had a 16 kb insert that encoded enzymatic activities for the light reaction as well as regulatory functions necessary for expression of the luminescen...


    pub_type: 杂志文章


    authors: Engebrecht J,Nealson K,Silverman M

    更新日期:1983-03-01 00:00:00

  • RAP-1 factor is necessary for DNA loop formation in vitro at the silent mating type locus HML.

    abstract::DNA fragments containing the silencers that flank the mating type genes at HML alpha are shown to bind specifically to the nuclear scaffold of yeast. The scaffold proteins are solubilized with urea and then renatured to form a soluble extract which allows reconstitution of sequence-specific DNA loops. At the silent ma...


    pub_type: 杂志文章


    authors: Hofmann JF,Laroche T,Brand AH,Gasser SM

    更新日期:1989-06-02 00:00:00

  • Stem cells and cancer: two faces of eve.

    abstract::Recent evidence suggests that a subset of cancer cells within some tumors, the so-called cancer stem cells, may drive the growth and metastasis of these tumors. Understanding the pathways that regulate proliferation, self-renewal, survival, and differentiation of malignant and normal stem cells may shed light on mecha...


    pub_type: 杂志文章


    authors: Clarke MF,Fuller M

    更新日期:2006-03-24 00:00:00

  • Site-specific base substitution and deletion mutations that enhance or suppress transcription of the SV40 major late RNA.

    abstract::Transcriptional analysis of SV40 late promoter mutants indicates that the DNA sequence 5'-GGTACCTAACC-3' (map positions 294-304) is important in the control of SV40 late RNA expression. C to T base substitutions at map positions 298, 299 and 304 increased initiation of late RNA synthesis at map position 325 five to te...


    pub_type: 杂志文章


    authors: Brady J,Radonovich M,Vodkin M,Natarajan V,Thoren M,Das G,Janik J,Salzman NP

    更新日期:1982-12-01 00:00:00

  • A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.

    abstract::Telomere capping is the essential function of telomeres. To identify new genes involved in telomere capping, we carried out a genome-wide screen in Saccharomyces cerevisiae for suppressors of cdc13-1, an allele of the telomere-capping protein Cdc13. We report the identification of five novel suppressors, including the...


    pub_type: 杂志文章


    authors: Downey M,Houlsworth R,Maringele L,Rollie A,Brehme M,Galicia S,Guillard S,Partington M,Zubko MK,Krogan NJ,Emili A,Greenblatt JF,Harrington L,Lydall D,Durocher D

    更新日期:2006-03-24 00:00:00

  • RNA-mediated recombination in S. cerevisiae.

    abstract::The existence of pseudogenes and the observation of intron loss suggest that RNA can serve as an intermediate in recombination. We used a HIS3 reporter gene to show that RNA-mediated recombination occurs in yeast. His3+ prototroph formation required transcription and expression of the retrotransposon Ty. Two RNA-media...


    pub_type: 杂志文章


    authors: Derr LK,Strathern JN,Garfinkel DJ

    更新日期:1991-10-18 00:00:00

  • Facilitated recycling pathway for RNA polymerase III.

    abstract::We show that the high in vitro transcription efficiency of yeast RNA pol III is mainly due to rapid recycling. Kinetic analysis shows that RNA polymerase recycling on preassembled tDNA.TFIIIC.TFIIIB complexes is much faster than the initial transcription cycle. High efficiency of RNA pol III recycling is favored at hi...


    pub_type: 杂志文章


    authors: Dieci G,Sentenac A

    更新日期:1996-01-26 00:00:00

  • Cloning and characterization of the integrated viral DNA from three lines of SV40-transformed mouse cells.

    abstract::Recombinant DNA techniques have been used to isolate the integrated viral DNA, together with flanking cellular sequences, from three independently isolated lines of SV40-transformed BALB/c 3T3 cells. We have determined the structures of these cloned segments and their relationships to one another by restriction enzyme...


    pub_type: 杂志文章


    authors: Clayton CE,Rigby PW

    更新日期:1981-08-01 00:00:00

  • Uniformity from Diversity: Vast-Range Light Sensing in a Single Neuron Type.

    abstract::The brightness of our visual environment varies tremendously from day to night. In this issue of Cell, Milner and Do describe how the population of retinal neurons responsible for entrainment of the brain's circadian clock cooperate to encode irradiance across a wide range of ambient-light intensities. ...


    pub_type: 评论,杂志文章


    authors: Varadarajan SG,Huberman AD

    更新日期:2017-11-02 00:00:00