Nuclear Receptors, RXR, and the Big Bang.

abstract：:The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion. ...

journal_title：Cell

authors： Dimitrov DS

更新日期：2003-12-12 00:00:00

abstract：:A mutation in any one of eight spoO genes of Bacillus subtilis blocks the process of spore formation at its earliest stage. To investigate how the products of the spoO genes may be involved in developmental gene expression, we fused the lacZ gene of E. coli to spoVG, a sporulation gene whose induction at the onset of ...

journal_title：Cell

authors： Zuber P,Losick R

更新日期：1983-11-01 00:00:00

abstract：:Exchange factors for ARF GTPases (ARF-GEFs) regulate vesicle trafficking in a variety of organisms. The Arabidopsis protein GNOM is a brefeldin A (BFA) sensitive ARF-GEF that is required for the proper polar localization of PIN1, a candidate transporter of the plant hormone auxin. Mutations in GNOM lead to development...

journal_title：Cell

authors： Geldner N,Anders N,Wolters H,Keicher J,Kornberger W,Muller P,Delbarre A,Ueda T,Nakano A,Jürgens G

更新日期：2003-01-24 00:00:00

abstract：:The chronic autoimmune diseases include multiple complex genetic disorders. Recently, genome-wide association studies (GWAS) have identified a large number of major loci, with many associations shared between various autoimmune diseases. These associations highlight key roles for lymphocyte activation and prioritize s...

journal_title：Cell

authors： Zenewicz LA,Abraham C,Flavell RA,Cho JH

更新日期：2010-03-19 00:00:00

abstract：:Proteolytic fragments of human plasma fibronectin were used to identify monoclonal antibodies reacting with the various domains of fibronectin. One of these antibodies, which reacts with cell-attachment-promoting fragments of fibronectin, inhibits attachment of cells to fibronectin-coated surfaces. A cell-attachment-p...

journal_title：Cell

authors： Pierschbacher MD,Hayman EG,Ruoslahti E

更新日期：1981-10-01 00:00:00

abstract：:TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation. ...

journal_title：Cell

authors： Tsai CL,Tainer JA

更新日期：2013-12-19 00:00:00

abstract：:Unique loci in the human genome were examined with restriction enzymes in order to detect restriction fragment length polymorphisms (RFLPs). Of 31 arbitrary loci, nine were detectably polymorphic, reflecting ten polymorphic restriction sites. Nine of the ten polymorphic sites were revealed with two restriction enzymes...

journal_title：Cell

authors： Barker D,Schafer M,White R

更新日期：1984-01-01 00:00:00

abstract：:The orderly reduction in chromosome number that occurs during meiosis depends on two aspects of chromosome behavior specific to the first meiotic division. These are the retention of cohesion between sister centromeres and their attachment to microtubules that extend to the same pole (monopolar attachment). By deletin...

journal_title：Cell

authors： Tóth A,Rabitsch KP,Gálová M,Schleiffer A,Buonomo SB,Nasmyth K

更新日期：2000-12-22 00:00:00

abstract：:32P-labeled cowpea mosaic virus (CPMV) RNAs were analyzed for their 5' termini by three different fingerprinting standard procedures. These analyses showed unequivocally that CPMV RNAs lack a structure like m7GpppN ... at their 5' termini. In addition, neither mono-, di- or triphosphorylated [(p)(p)pN ....] termini we...

journal_title：Cell

authors： Klootwijk J,Klein I,Zabel P,van Kammen A

更新日期：1977-05-01 00:00:00

abstract：:The mechanism by which nucleosome cores are displaced and re-formed during transcription in vitro has been investigated. A nucleosome core was assembled on a short linear DNA template (227 bp) containing an SP6 RNA polymerase promoter and a nucleosome-positioning sequence. Transcription induced the translocation of th...

journal_title：Cell

authors： Studitsky VM,Clark DJ,Felsenfeld G

更新日期：1994-01-28 00:00:00

abstract：:How difficult is to go from egg to implanted embryo? The evolution of placentation in eutherian mammals created enormous challenges, in particular to the maternal immune system, as the fetus expresses paternal antigens that are capable of triggering immune rejection. Samstein et al. reveal a role for inducible regulat...

journal_title：Cell

authors： Gobert M,Lafaille JJ

更新日期：2012-07-06 00:00:00

abstract：:3.18 kb fragments of X. laevis DNA coding for tRNA 1 met have been inserted into a lambda vector via Hind III termini and cloned in E. coli. The organization of one cloned fragment has been analyzed by restriction endonuclease digestion and RNA-DNA hybridization. From the distribution of sites for three enzymes, this ...

journal_title：Cell

authors： Clarkson SG,Kurer V,Smith HO

更新日期：1978-07-01 00:00:00

abstract：:The trk tyrosine kinase proto-oncogene product gp140prototrk binds nerve growth factor (NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine whether gp140prototrk is involved in transducing a functional NGF signal, PC12 cell mutants (PC12nnr) deficient in high affinity NGF binding an...

journal_title：Cell

authors： Loeb DM,Maragos J,Martin-Zanca D,Chao MV,Parada LF,Greene LA

更新日期：1991-09-06 00:00:00

abstract：:The genetic structure of Mason-Pfizer monkey virus (MPMV), a D-type retrovirus, has been determined. In addition to the viral gag, pol, and env genes is an ORF overlapping both gag and pol and that encodes the viral protease. Surprisingly, the MPMV env protein is highly homologous to that of the avian C-type virus, re...

journal_title：Cell

authors： Sonigo P,Barker C,Hunter E,Wain-Hobson S

更新日期：1986-05-09 00:00:00

abstract：:The mammalian alpha- and beta--globin genes are thought to have evolved from a common ancestral sequence by a duplication event that occurred over 500 million years ago. We have now determined the entire nucleotide sequence of a cloned mouse alpha--globin gene, including regions that flank and interrupt the coding seq...

journal_title：Cell

authors： Nishioka Y,Leder P

更新日期：1979-11-01 00:00:00

abstract：:SOCS1 is an SH2-containing protein that is primarily expressed in thymocytes in a cytokine- and T cell receptor-independent manner. SOCS1 deletion causes perinatal lethality with death by 2-3 weeks. During this period thymic changes include a loss of cellularity and a switch from predominantly CD4+ CD8+ to single posi...

journal_title：Cell

authors： Marine JC,Topham DJ,McKay C,Wang D,Parganas E,Stravopodis D,Yoshimura A,Ihle JN

更新日期：1999-09-03 00:00:00

abstract：:Mitochondrial DNA from bovine tissue contains heterogeneous sequences located within an evolutionary conserved cytosine homopolymer sequence near the 5' end of the D-loop region. This part of the mammalian mitochondrial genome is known to contain the origin of heavy strand DNA synthesis and the major transcriptional p...

journal_title：Cell

authors： Hauswirth WW,Van de Walle MJ,Laipis PJ,Olivo PD

更新日期：1984-07-01 00:00:00

abstract：:O(2) is the ultimate electron acceptor for mitochondrial respiration, a process catalyzed by cytochrome c oxidase (COX). In yeast, COX subunit composition is regulated by COX5a and COX5b gene transcription in response to high and low O(2), respectively. Here we demonstrate that in mammalian cells, expression of the CO...

journal_title：Cell

authors： Fukuda R,Zhang H,Kim JW,Shimoda L,Dang CV,Semenza GL

更新日期：2007-04-06 00:00:00

abstract：:The central vasculature of plant roots is protected by a hydrophobic ring of endodermal cells that are enclosed by lamellae of suberin. Barberon et al. demonstrate that endodermal suberization plasticity facilitates ion homeostasis, with antithetical regulation of suberin deposition and degradation by the phytohormone...

journal_title：Cell

authors： Pauluzzi G,Bailey-Serres J

更新日期：2016-01-28 00:00:00

abstract：:We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. ...

journal_title：Cell

authors： Leahy DJ,Aukhil I,Erickson HP

更新日期：1996-01-12 00:00:00

abstract：:We have analyzed two mutations of the white-eye gene, which arose in flies subject to I-R hybrid dysgenesis. These mutations are associated with insertions of apparently identical 5.4 kb sequences, which we have cloned. We believe that these insertions are copies of the I factor controlling I-R hybrid dysgenesis. The ...

journal_title：Cell

authors： Bucheton A,Paro R,Sang HM,Pelisson A,Finnegan DJ

更新日期：1984-08-01 00:00:00

abstract：:Clathrin-mediated endocytosis plays a major role in retrieving synaptic vesicles from the plasma membrane following exocytosis. This endocytic process requires AP180 (or a homolog), which promotes the assembly and restricts the size of clathrin-coated vesicles. The highly conserved 33 kDa amino-terminal domain of AP18...

journal_title：Cell

authors： Mao Y,Chen J,Maynard JA,Zhang B,Quiocho FA

更新日期：2001-02-09 00:00:00

abstract：:Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These states are associated w...

journal_title：Cell

authors： Imamovic L,Ellabaan MMH,Dantas Machado AM,Citterio L,Wulff T,Molin S,Krogh Johansen H,Sommer MOA

更新日期：2018-01-11 00:00:00

abstract：:We have tested a model for global ribosome biosynthesis by examining the effects of increased gene dosage on the synthesis of rRNA. Increasing gene dosage does not lead to a significant increase in total rRNA transcription; i.e., rRNA synthesis from individual rRNA operons is reduced to keep total rRNA production unch...

journal_title：Cell

authors： Jinks-Robertson S,Gourse RL,Nomura M

更新日期：1983-07-01 00:00:00

abstract：:While hematopoietic stem cell (HSC) self-renewal is well studied, it remains unknown whether distinct control mechanisms enable HSC divisions that generate progeny cells with specific lineage bias. Here, we report that the monocytic transcription factor MafB specifically restricts the ability of M-CSF to instruct myel...

journal_title：Cell

authors： Sarrazin S,Mossadegh-Keller N,Fukao T,Aziz A,Mourcin F,Vanhille L,Kelly Modis L,Kastner P,Chan S,Duprez E,Otto C,Sieweke MH

更新日期：2009-07-23 00:00:00

abstract：:P-selectin binding to neutrophils requires a specific protein, P-selectin glycoprotein ligand 1 (PSGL-1), as well as sialyl-Lewis X (sLex) glycan determinants. We have found that a short segment near the amino terminus of PSGL-1 that contains a tyrosine sulfation consensus is essential for P-selectin adhesion and that...

journal_title：Cell

authors： Pouyani T,Seed B

更新日期：1995-10-20 00:00:00

abstract：:We present evidence that the genes encoding U3 snRNA in plants are transcribed by RNA polymerase III (pol III) and not by RNA polymerase II (pol II) as in vertebrates or lower eukaryotes. The U3 gene is the only known example of a gene transcribed by different polymerases in different organisms. It is possible to conv...

journal_title：Cell

authors： Kiss T,Marshallsay C,Filipowicz W

更新日期：1991-05-03 00:00:00

abstract：:Potassium channels embedded in cell membranes employ gates to regulate K+ current. While a specific constriction in the permeation pathway has historically been implicated in gating, recent reports suggest that the signature ion selectivity filter located in the outer membrane leaflet may be equally important. Inwardl...

journal_title：Cell

authors： Clarke OB,Caputo AT,Hill AP,Vandenberg JI,Smith BJ,Gulbis JM

更新日期：2010-06-11 00:00:00

abstract：:Lipid biology continues to emerge as an area of significant therapeutic interest, particularly as the result of an enhanced understanding of the wealth of signaling molecules with diverse physiological properties. This growth in knowledge is epitomized by lysophosphatidic acid (LPA), which functions through interactio...

journal_title：Cell

authors： Chrencik JE,Roth CB,Terakado M,Kurata H,Omi R,Kihara Y,Warshaviak D,Nakade S,Asmar-Rovira G,Mileni M,Mizuno H,Griffith MT,Rodgers C,Han GW,Velasquez J,Chun J,Stevens RC,Hanson MA

更新日期：2015-06-18 00:00:00

abstract：:Kinetochores connect centromeric nucleosomes with mitotic-spindle microtubules through conserved, cross-interacting protein subassemblies. In budding yeast, the heterotetrameric MIND complex (Mtw1, Nnf1, Nsl1, Dsn1), ortholog of the metazoan Mis12 complex, joins the centromere-proximal components, Mif2 and COMA, with ...

journal_title：Cell

authors： Dimitrova YN,Jenni S,Valverde R,Khin Y,Harrison SC

更新日期：2016-11-03 00:00:00