Abstract：
:The mammalian alpha- and beta--globin genes are thought to have evolved from a common ancestral sequence by a duplication event that occurred over 500 million years ago. We have now determined the entire nucleotide sequence of a cloned mouse alpha--globin gene, including regions that flank and interrupt the coding sequence, and have compared this sequence with the sequences of the two mouse beta--globin genes (Konkel, Tilghman and Leder, 1978; Konkel, Maizel and Leder, 1979). Like the two beta genes, the alpha gene is interrupted by two intervening sequences at precisely homologous positions, suggesting that these interruptions were present and have been preserved throughout vertebrate evolution. While the alpha and beta genes conserve considerable (approximately 55%) sequence homology in their coding regions, this homology--with certain interesting exceptions--is lost in the highly divergent flanking and intervening sequences. These exceptions are short preserved sequences positioned in such a way that they might encode signals for transcriptional initiation, poly(A) addition and RNA splicing. Furthermore, a comparison of the recently divererged beta genes and the long separate alpha gene allows us to distinguish two clearly different modes of nucleotide sequence change in evolution: a fast mode which is characterized by drastic sequence alterations involving deletions and insertions, and a slow mode which preserves sequence homology to a large extent and involves mainly point mutations.
journal_name
Celljournal_title
Cellauthors
Nishioka Y,Leder Pdoi
10.1016/0092-8674(79)90139-9subject
Has Abstractpub_date
1979-11-01 00:00:00pages
875-82issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(79)90139-9journal_volume
18pub_type
杂志文章相关文献
CELL文献大全abstract：:Embryonal carcinoma cells derived from murine teratocarcinomas are able to differentiate into the same variety of tissue types as early embryonic cells. Because embryonal carcinoma cells resemble those of the embryo at a stage before X chromosome inactivation has occurred in females embryonal carcinoma cells containin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90052-0
更新日期：1976-09-01 00:00:00
abstract：:How cells generate a single axis of polarity for mating, division, and movement is unknown. In this issue, Howell et al. (2009) use a synthetic biology approach to demonstrate that rapid competition for a soluble signaling component (Bem1) is essential to ensure a unique axis of polarity in budding yeast. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2009.10.028
更新日期：2009-11-13 00:00:00
abstract：:A gene for Saccharomyces cerevisiae tRNATrp has been sequenced which contains an intervening sequence of 34 bp (H. S. Kang and J. Abelson, unpublished results). The mutant yeast strain ts-136 accumulates a precursor to tRNATrp which contains mature ends and is colinear with the tRNATrp gene. A nuclear extract from Xen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90166-1
更新日期：1979-06-01 00:00:00
abstract：:The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome sequencing of the virus. Herein, we describe what genomic data reveal about the emergence SARS-CoV-2 and discuss the gaps in our understanding of its origins. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.03.035
更新日期：2020-04-16 00:00:00
abstract：:DNA repair is an essential process for preserving genome integrity in all organisms. In eukaryotes, recombinational repair is choreographed by multiprotein complexes that are organized into centers (foci). Here, we analyze the cellular response to DNA double-strand breaks (DSBs) and replication stress in Saccharomyces...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.08.015
更新日期：2004-09-17 00:00:00
abstract：:Translation of ribosomal proteins in the alpha operon of E. coli is repressed by one of the encoded proteins, S4; it specifically recognizes an RNA fragment containing the translational initiation site for the first gene in the operon. RNA structure mapping experiments have suggested a pseudoknot structure for the S4 ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90123-2
更新日期：1989-05-19 00:00:00
abstract：:Plants rely heavily on environmental cues to control the timing of developmental transitions. We are beginning to better understand what determines the timing of two of these transitions, the switch from juvenile to adult vegetative development and the transition to flowering. In this review, we discuss how RNA silenc...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2006.05.005
更新日期：2006-05-19 00:00:00
abstract：:There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but research advances over the past three decades could change this gloomy picture. Genetic studies demonstrate that the disease has multiple causes. Interdisciplinary approaches combining biochemistry, molecular and cell biology...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2012.02.040
更新日期：2012-03-16 00:00:00
abstract：:The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to tension gradients. It is widely assumed that membrane flow transmits local changes in membrane tension across the cell in milliseconds, mediating long-range signaling. Here, we show that propagation of membrane tension occurs qu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.09.054
更新日期：2018-12-13 00:00:00
abstract：:Rapid flow of information in the nervous system involves presynaptic vesicle recycling by clathrin-mediated endocytosis, an event triggered by the alpha-adaptin-containing AP2 complex. We identified a Drosophila alpha-adaptin expressed in the garland cells, imaginal discs, and the CNS. Here we show its role in presyna...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81923-6
更新日期：1997-03-21 00:00:00
abstract：:Many biological motor molecules move within cells using stepsizes predictable from their structures. Myosin VI, however, has much larger and more broadly distributed stepsizes than those predicted from its short lever arms. We explain the discrepancy by monitoring Qdots and gold nanoparticles attached to the myosin-VI...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.08.033
更新日期：2010-09-17 00:00:00
abstract：:Cancer cells enter a reversible drug-tolerant persister (DTP) state to evade death from chemotherapy and targeted agents. It is increasingly appreciated that DTPs are important drivers of therapy failure and tumor relapse. We combined cellular barcoding and mathematical modeling in patient-derived colorectal cancer mo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.11.018
更新日期：2021-01-07 00:00:00
abstract：:The mec-3 gene is essential for proper differentiation of the set of six touch receptor neurons in C. elegans. In mutants lacking mec-3 activity, the touch receptors express none of their unique differentiated features and appear to be transformed into other types of neurons. We cloned the mec-3 gene by transposon tag...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90174-2
更新日期：1988-07-01 00:00:00
abstract：:The cpd mutation localized by T-DNA tagging on Arabidopsis chromosome 5-14.3 inhibits cell elongation controlled by the ecdysone-like brassinosteroid hormone brassinolide. The cpd mutant displays de-etiolation and derepression of light-induced genes in the dark, as well as dwarfism, male sterility, and activation of s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81094-6
更新日期：1996-04-19 00:00:00
abstract：:Human hepatitis B virus core protein expressed in E. coli assembles into two sizes of particle. We have determined their three-dimensional structures by electron cryomicroscopy and image processing. The large and small particles correspond to triangulation number T = 4 and T = 3 dimer clustered packings, containing 24...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(94)90142-2
更新日期：1994-06-17 00:00:00
abstract：:Small nucleolar RNAs represent an abundant, evolutionarily ancient group of noncoding RNAs which possess impressively diverse functions ranging from 2'-O-methylation and pseudouridylation of various classes of RNAs, through nucleolytic processing of rRNAs to the synthesis of telomeric DNA. ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/s0092-8674(02)00718-3
更新日期：2002-04-19 00:00:00
abstract：:Mitochondrial respiratory-chain complexes assemble from subunits of dual genetic origin assisted by specialized assembly factors. Whereas core subunits are translated on mitochondrial ribosomes, others are imported after cytosolic translation. How imported subunits are ushered to assembly intermediates containing mito...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.11.053
更新日期：2012-12-21 00:00:00
abstract：:Plant seedling development is capable of following 1 of 2 distinct morphogenic pathways: skotomorphogenesis in darkness and photomorphogenesis in light. Dark-grown Arabidopsis seedlings with recessive mutations at the constitutively photomorphogenic (COP1) locus indicate that the wild-type COP1 protein represses photo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90555-q
更新日期：1992-11-27 00:00:00
abstract：:The single most frequent cancer-causing mutation across all heterotrimeric G proteins is R201C in Gαs. The current model explaining the gain-of-function activity of the R201 mutations is through the loss of GTPase activity and resulting inability to switch off to the GDP state. Here, we find that the R201C mutation ca...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.03.018
更新日期：2018-05-17 00:00:00
abstract：:We have shown that in fixed mitotic chromosomes from female G. gerbillus cells the inactive X chromosome is distinctly less sensitive to DNAase I than the active X chromosome, as demonstrated by in situ nick translation. These results indicated that the specific chromatin conformation that renders potentially active g...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(84)90504-x
更新日期：1984-09-01 00:00:00
abstract：:An injection of aphidicolin into early Drosophila embryos inhibits DNA synthesis and nuclear division, while centrosome replication and many other aspects of the mitotic cycle continue. If aphidicolin is injected at nuclear cycle 7-8, the normal migration of nuclei to the embryo cortex is completely inhibited. In most...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90130-x
更新日期：1989-05-19 00:00:00
abstract：:Yeast heat shock protein 104 (Hsp104), the only known eukaryotic disaggregase, remodels both disordered protein aggregates and cross-β sheet amyloids. To handle this diverse clientele, DeSantis et al. report that Hsp104 hexamers use distinct mechanisms-individual subunits are able to dissolve disordered aggregates, bu...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2012.10.033
更新日期：2012-11-09 00:00:00
abstract：:Phages must be perfectly attuned to bacterial host cell physiology to ensure their optimal survival. Silpe and Bassler show that a Vibrio phage uses the host quorum-sensing pathway to trigger production of viral progeny at high cell density. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2018.12.007
更新日期：2019-01-10 00:00:00
abstract：:Understanding how potent neutralizing antibodies (NAbs) inhibit SARS-CoV-2 is critical for effective therapeutic development. We previously described BD-368-2, a SARS-CoV-2 NAb with high potency; however, its neutralization mechanism is largely unknown. Here, we report the 3.5-Å cryo-EM structure of BD-368-2/trimeric-...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.09.035
更新日期：2020-11-12 00:00:00
abstract：:Metabolic coordination between neurons and astrocytes is critical for the health of the brain. However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural activity, remains largely uncharacterized. Here, we demonstrate that toxic fatty acids (FAs) produced in hyperactive neurons are tran...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.04.001
更新日期：2019-05-30 00:00:00
abstract：:We have identified a gene, SRV2, mutations of which alleviate stress sensitivity in strains carrying an activated RAS gene. Epistasis analysis suggests that the gene affects accumulation of cAMP in the cell. Direct assays of cAMP accumulation indicate that mutations of the gene diminish the rate of in vivo production ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90813-t
更新日期：1990-04-20 00:00:00
abstract：:The transcription factor ATF2 elicits oncogenic activities in melanoma and tumor suppressor activities in nonmalignant skin cancer. Here, we identify that ATF2 tumor suppressor function is determined by its ability to localize at the mitochondria, where it alters membrane permeability following genotoxic stress. The a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.01.016
更新日期：2012-02-03 00:00:00
abstract：:The mitochondrial RNA binding proteins MRP1 and MRP2 form a heteromeric complex that functions in kinetoplastid RNA editing. In this process, MRP1/MRP2 serves as a matchmaker by binding to guide RNAs and facilitating their hybridization with cognate preedited mRNAs. To understand the mechanism by which this complex pe...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.06.047
更新日期：2006-08-25 00:00:00
abstract：:During asymmetric cell divisions, mitotic spindles align along the axis of polarization. In invertebrates, spindle positioning requires Pins or related proteins and a G protein alpha subunit. A mammalian Pins, called LGN, binds Galphai and also interacts through an N-terminal domain with the microtubule binding protei...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.10.028
更新日期：2004-11-12 00:00:00
abstract：:The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00976-0
更新日期：2003-12-12 00:00:00
