Abstract：
:Unique loci in the human genome were examined with restriction enzymes in order to detect restriction fragment length polymorphisms (RFLPs). Of 31 arbitrary loci, nine were detectably polymorphic, reflecting ten polymorphic restriction sites. Nine of the ten polymorphic sites were revealed with two restriction enzymes, Msp I and Taq I, whose recognition sequences have in common the dimer sequence CpG. The cytosines in the CpG sequence are known to be frequently methylated in mammals, and the occurrence of significant variation in Msp I and Taq I sites supports the view that methylated cytosine residues are hotspots for mutation in mammalian DNA.
journal_name
Celljournal_title
Cellauthors
Barker D,Schafer M,White Rdoi
10.1016/0092-8674(84)90081-3subject
Has Abstractpub_date
1984-01-01 00:00:00pages
131-8issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(84)90081-3journal_volume
36pub_type
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