Abstract：
:We present an integrated analysis of the clinical measurements, immune cells, and plasma multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial blood draws collected during the first week of infection following diagnosis. We identify a major shift between mild and moderate disease, at which point elevated inflammatory signaling is accompanied by the loss of specific classes of metabolites and metabolic processes. Within this stressed plasma environment at moderate disease, multiple unusual immune cell phenotypes emerge and amplify with increasing disease severity. We condensed over 120,000 immune features into a single axis to capture how different immune cell classes coordinate in response to SARS-CoV-2. This immune-response axis independently aligns with the major plasma composition changes, with clinical metrics of blood clotting, and with the sharp transition between mild and moderate disease. This study suggests that moderate disease may provide the most effective setting for therapeutic intervention.
journal_name
Celljournal_title
Cellauthors
Su Y,Chen D,Yuan D,Lausted C,Choi J,Dai CL,Voillet V,Duvvuri VR,Scherler K,Troisch P,Baloni P,Qin G,Smith B,Kornilov SA,Rostomily C,Xu A,Li J,Dong S,Rothchild A,Zhou J,Murray K,Edmark R,Hong S,Heath JE,Eardoi
10.1016/j.cell.2020.10.037subject
Has Abstractpub_date
2020-12-10 00:00:00pages
1479-1495.e20issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(20)31444-6journal_volume
183pub_type
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