The role of Fas in autoimmune diabetes.

abstract：:Acquisition of the ability to produce and respond to a growth factor may result in increased cellular proliferation and could lead to malignant transformation. The fact that a large variety of tumor cells secrete transforming growth factor-alpha (TGF-alpha) suggests involvement of TGF-alpha in cellular transformation ...

journal_title：Cell

authors： Rosenthal A,Lindquist PB,Bringman TS,Goeddel DV,Derynck R

更新日期：1986-07-18 00:00:00

abstract：:The genetics of complex disease produce alterations in the molecular interactions of cellular pathways whose collective effect may become clear through the organized structure of molecular networks. To characterize molecular systems associated with late-onset Alzheimer's disease (LOAD), we constructed gene-regulatory ...

journal_title：Cell

authors： Zhang B,Gaiteri C,Bodea LG,Wang Z,McElwee J,Podtelezhnikov AA,Zhang C,Xie T,Tran L,Dobrin R,Fluder E,Clurman B,Melquist S,Narayanan M,Suver C,Shah H,Mahajan M,Gillis T,Mysore J,MacDonald ME,Lamb JR,Bennett DA,

更新日期：2013-04-25 00:00:00

abstract：:A transglutaminase-catalyzed cross-linking process characteristic of keratinocytes leads to the formation of the insoluble corneocyte envelope. The essentials of this process take place in vitro in a reconstituted system derived from subcellular fractions. A particulate fraction containing membrane-bound envelope prec...

journal_title：Cell

authors： Simon M,Green H

更新日期：1985-03-01 00:00:00

abstract：:The transport kinetics of the influenza virus hemagglutinin from its site of synthesis to the apical plasma membrane of Madin-Darby canine kidney cells, a polarized epithelial cell line, were studied by a sensitive tryptic assay. Hemagglutinin acquired terminal sugars, as judged by sensitivity to endo-beta-N-acetylglu...

journal_title：Cell

authors： Matlin KS,Simons K

更新日期：1983-08-01 00:00:00

abstract：:Proliferating cell nuclear antigen (PCNA) is a cell cycle and growth regulated protein required for replication of SV40 DNA in vitro. Its function was investigated by comparison of the replication products synthesized in its presence or absence. In the completely reconstituted replication system that contains PCNA, DN...

journal_title：Cell

authors： Prelich G,Stillman B

更新日期：1988-04-08 00:00:00

abstract：:Clonal derivatives of C3HMT murine mammary cell lines in culture demonstrate conversion of mammary tumor virus (MMTV) expression at a rate of appriximately 6 per 100 clones. This alteration is largely unidirectional from a relatively high level (MMTV(H)) to a 10 fold lower level (MMTV(L)). This high rate of MMTV(L) va...

journal_title：Cell

authors： Parks WP,Hubbell ES,Goldberg RJ,O'Neill FJ,Scolnick EM

更新日期：1976-05-01 00:00:00

abstract：:The Rho family of GTPases control diverse biological processes, including cell morphology and mitogenesis. We have identified WASP, the protein that is defective in Wiskott-Aldrich syndrome (WAS), as a novel effector for CDC42Hs, but not for the other Rho family members, Rac and Rho. This interaction is dependent on t...

journal_title：Cell

authors： Symons M,Derry JM,Karlak B,Jiang S,Lemahieu V,Mccormick F,Francke U,Abo A

更新日期：1996-03-08 00:00:00

abstract：:The Drosophila transforming growth factor beta (TGF-beta) homolog Decapentaplegic (Dpp) acts as a morphogen that forms a long-range concentration gradient to direct the anteroposterior patterning of the wing. Both planar transcytosis initiated by Dynamin-mediated endocytosis and extracellular diffusion have been propo...

journal_title：Cell

authors： Belenkaya TY,Han C,Yan D,Opoka RJ,Khodoun M,Liu H,Lin X

更新日期：2004-10-15 00:00:00

abstract：:DNA transcription, replication, and repair are regulated by histone acetylation, a process that requires the generation of acetyl-coenzyme A (CoA). Here, we show that all the subunits of the mitochondrial pyruvate dehydrogenase complex (PDC) are also present and functional in the nucleus of mammalian cells. We found t...

journal_title：Cell

authors： Sutendra G,Kinnaird A,Dromparis P,Paulin R,Stenson TH,Haromy A,Hashimoto K,Zhang N,Flaim E,Michelakis ED

更新日期：2014-07-03 00:00:00

abstract：:We mutated, by gene targeting, the endogenous hypoxanthine phosphoribosyl transferase (HPRT) gene in mouse embryo-derived stem (ES) cells. A specialized construct of the neomycin resistance (neor) gene was introduced into an exon of a cloned fragment of the Hprt gene and used to transfect ES cells. Among the G418r col...

journal_title：Cell

authors： Thomas KR,Capecchi MR

更新日期：1987-11-06 00:00:00

abstract：:DNA polymerase (pol) β is a model polymerase involved in gap-filling DNA synthesis utilizing two metals to facilitate nucleotidyl transfer. Previous structural studies have trapped catalytic intermediates by utilizing substrate analogs (dideoxy-terminated primer or nonhydrolysable incoming nucleotide). To identify add...

journal_title：Cell

authors： Freudenthal BD,Beard WA,Shock DD,Wilson SH

更新日期：2013-07-03 00:00:00

abstract：:In an era marked by the increasing prevalence of obesity, diabetes, and cardiovascular disease, the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) has emerged as a transcriptional regulator of metabolism whose activity can be modulated by direct binding of small molecules. As the master ...

journal_title：Cell

authors： Lehrke M,Lazar MA

更新日期：2005-12-16 00:00:00

abstract：:Loss of cell polarity proteins such as Scribble induces neoplasia in Drosophila by promoting uncontrolled proliferation. In mammals, the role that polarity proteins play during tumorigenesis is not well understood. Here, we demonstrate that depletion of Scribble in mammary epithelia disrupts cell polarity, blocks thre...

journal_title：Cell

authors： Zhan L,Rosenberg A,Bergami KC,Yu M,Xuan Z,Jaffe AB,Allred C,Muthuswamy SK

更新日期：2008-11-28 00:00:00

abstract：:Nine transcripts complementary to mouse L cell mitochondrial DNA have been detected, sized and mapped to restriction fragments using the method of Berk and Sharp (1977). RNA isolated from L cell mitochondria was hybridized to 32P-labeled, cloned L cell mitochondrial DNA restriction fragments in 70% formamide under con...

journal_title：Cell

authors： Battey J,Clayton DA

更新日期：1978-05-01 00:00:00

abstract：:The Viviparous-1 (Vp1) gene of maize is specifically required for expression of the maturation program in seed development. We show that Vp1 encodes a 73,335 dalton protein with no detectable homology to known proteins. An acidic transcriptional activation sequence was identified by fusion to the GAL4 DNA-binding doma...

journal_title：Cell

authors： McCarty DR,Hattori T,Carson CB,Vasil V,Lazar M,Vasil IK

更新日期：1991-09-06 00:00:00

abstract：:Cell-cell junctions respond to mechanical forces by changing their organization and function. To gain insight into the mechanochemical basis underlying junction mechanosensitivity, we analyzed tight junction (TJ) formation between the enveloping cell layer (EVL) and the yolk syncytial layer (YSL) in the gastrulating z...

journal_title：Cell

authors： Schwayer C,Shamipour S,Pranjic-Ferscha K,Schauer A,Balda M,Tada M,Matter K,Heisenberg CP

更新日期：2019-10-31 00:00:00

abstract：:The dynamic synapse is represented by the constant mobility and exchange of components at both the cell surface and at intracellular sites. This includes thermally powered Brownian diffusion movement, followed by reversible trapping through receptor-scaffold interactions and active transport of cargo vesicles through ...

journal_title：Cell

authors： Kneussel M,Triller A,Choquet D

更新日期：2014-06-19 00:00:00

abstract：:Bcl-2 protein is able to repress a number of apoptotic death programs. To investigate the mechanism of Bcl-2's effect, we examined whether Bcl-2 interacted with other proteins. We identified an associated 21 kd protein partner, Bax, that has extensive amino acid homology with Bcl-2, focused within highly conserved dom...

journal_title：Cell

authors： Oltvai ZN,Milliman CL,Korsmeyer SJ

更新日期：1993-08-27 00:00:00

abstract：:Chromosome segregation at meiosis I depends on pairing and crossing-over between homologs. In most eukaryotes, pairing culminates with formation of the proteinaceous synaptonemal complex (SC). In budding yeast, recombination initiates through double-strand DNA breaks (DSBs) and is thought to be essential for SC format...

journal_title：Cell

authors： Dernburg AF,McDonald K,Moulder G,Barstead R,Dresser M,Villeneuve AM

更新日期：1998-08-07 00:00:00

abstract：:Strains of Saccharomyces that carry the nib allele of a nuclear gene exhibit a "nibbled" colony morphology if they also harbor the plasmid 2 mu DNA. I have found that the expression of the nibbled phenotype is correlated with the presence of a subpopulation of abnormally large cells that give rise to mortal clones. La...

journal_title：Cell

authors： Holm C

更新日期：1982-06-01 00:00:00

abstract：:CEM15/APOBEC3G is a cellular protein required for resistance to infection by virion infectivity factor (Vif)-deficient human immunodeficiency virus (HIV). Here, using a murine leukemia virus (MLV)-based system, we provide evidence that CEM15/APOBEC3G is a DNA deaminase that is incorporated into virions during viral pr...

journal_title：Cell

authors： Harris RS,Bishop KN,Sheehy AM,Craig HM,Petersen-Mahrt SK,Watt IN,Neuberger MS,Malim MH

更新日期：2003-06-13 00:00:00

abstract：:Chromosomal rearrangements, including translocations, require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are frequently involved in producing leukemias, lymphomas and sarcomas. Despite the importance of these events, current understanding of their gen...

journal_title：Cell

authors： Klein IA,Resch W,Jankovic M,Oliveira T,Yamane A,Nakahashi H,Di Virgilio M,Bothmer A,Nussenzweig A,Robbiani DF,Casellas R,Nussenzweig MC

更新日期：2011-09-30 00:00:00

abstract：:Neurons need to alter their response to a given stimulus over time in order for the animal to modify its behavior within a changing environment. Chen et al. now demonstrate that neuronal structure and function are altered coordinately by the history of the cell's activity through an unexpected molecular pathway. ...

journal_title：Cell

authors： Della Santina L,Wong RO

更新日期：2012-09-28 00:00:00

abstract：:During the SOS response, LexA repressor is inactivated by specific cleavage. Although cleavage requires RecA protein in vivo, RecA acts indirectly as a coprotease by stimulating an inherent self-cleavage activity of LexA. In lambda lysogens, cleavage of lambda Cl repressor in a similar but far slower reaction results ...

journal_title：Cell

authors： Kim B,Little JW

更新日期：1993-06-18 00:00:00

abstract：:The transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homolog (pp60c-src) are demonstrated to be phosphorylated at serine 12 in vivo under certain conditions. We propose that protein kinase C is responsible for this modification based on the following evidence. First, the tumor promoters, ...

journal_title：Cell

authors： Gould KL,Woodgett JR,Cooper JA,Buss JE,Shalloway D,Hunter T

更新日期：1985-10-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is a novel respiratory illness caused by SARS-CoV-2. Viral entry is mediated through viral spike protein and host ACE2 enzyme interaction. Most cases are mild; severe disease often involves cytokine storm and organ failure. Therapeutics including antivirals, immunomodulators, and va...

journal_title：Cell

authors： Oberfeld B,Achanta A,Carpenter K,Chen P,Gilette NM,Langat P,Said JT,Schiff AE,Zhou AS,Barczak AK,Pillai S

更新日期：2020-05-14 00:00:00

abstract：:The S. cerevisiae CLN genes encode cyclin homologs essential for progression from G1 to S phase. The CLN2 gene encodes a 62 kd polypeptide that accumulates periodically, peaking during G1 and decreasing rapidly thereafter, and is rapidly lost following exposure of cells to mating pheromone. Cln2 abundance can be expla...

journal_title：Cell

authors： Wittenberg C,Sugimoto K,Reed SI

更新日期：1990-07-27 00:00:00

abstract：:Cis-regulatory elements (CREs) are commonly recognized by correlative chromatin features, yet the molecular composition of the vast majority of CREs in chromatin remains unknown. Here, we describe a CRISPR affinity purification in situ of regulatory elements (CAPTURE) approach to unbiasedly identify locus-specific chr...

journal_title：Cell

authors： Liu X,Zhang Y,Chen Y,Li M,Zhou F,Li K,Cao H,Ni M,Liu Y,Gu Z,Dickerson KE,Xie S,Hon GC,Xuan Z,Zhang MQ,Shao Z,Xu J

更新日期：2017-08-24 00:00:00

abstract：:We have examined the molecular organization of a region of mouse chromosome 17 that allows homologous recombination between wild-type and t haplotype chromosomes across a large inversion. We have used a combination of genetic mapping of restriction fragment length polymorphisms, molecular characterization of cloned re...

journal_title：Cell

authors： Herrmann BG,Barlow DP,Lehrach H

更新日期：1987-03-13 00:00:00

abstract：:P-selectin binding to neutrophils requires a specific protein, P-selectin glycoprotein ligand 1 (PSGL-1), as well as sialyl-Lewis X (sLex) glycan determinants. We have found that a short segment near the amino terminus of PSGL-1 that contains a tyrosine sulfation consensus is essential for P-selectin adhesion and that...

journal_title：Cell

authors： Pouyani T,Seed B

更新日期：1995-10-20 00:00:00