Abstract:
:We have examined the molecular organization of a region of mouse chromosome 17 that allows homologous recombination between wild-type and t haplotype chromosomes across a large inversion. We have used a combination of genetic mapping of restriction fragment length polymorphisms, molecular characterization of cloned regions isolated on overlapping cosmids, and subchromosomal restriction mapping using the pulsed field gel technique. Our analyses show that the wild-type form of chromosome 17 contains an inverted duplication of an element of at least 650 kb that is present in only one copy in the t haplotype form. Two chromosomes, th45 and tAE5, arose by homologous recombination across the element that is present in both chromosomal variants in the same orientation.
journal_name
Celljournal_title
Cellauthors
Herrmann BG,Barlow DP,Lehrach Hdoi
10.1016/0092-8674(87)90078-xsubject
Has Abstractpub_date
1987-03-13 00:00:00pages
813-25issue
5eissn
0092-8674issn
1097-4172pii
0092-8674(87)90078-Xjournal_volume
48pub_type
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