Abstract:
:The human geneticist Archibald Garrod noted in 1931 that, "It is, of necessity, no easy matter to distinguish between immunity which is inborn and that which has been acquired" (The Inborn Factors in Disease). In this issue of Cell, Brodin et al. show that the heritability of blood counts rapidly decreases with age for the lymphoid subsets responsible for adaptive immunity, unlike cells from other hematopoietic lineages.
journal_name
Celljournal_title
Cellauthors
Casanova JL,Abel Ldoi
10.1016/j.cell.2014.12.029subject
Has Abstractpub_date
2015-01-15 00:00:00pages
13-5issue
1-2eissn
0092-8674issn
1097-4172pii
S0092-8674(14)01635-3journal_volume
160pub_type
评论,杂志文章相关文献
CELL文献大全abstract::The molecular mediator and functional significance of meal-associated brown fat (BAT) thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non-sympathetic BAT activator mediating prandial thermogenesis, which consequentially induces satiation, thereby establishing a gut-secretin-BAT-brain a...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.10.016
更新日期:2018-11-29 00:00:00
abstract::Prion-like domains have emerged as important drivers of neurodegenerative disease. Now, Boulay et al. establish that the translocated prion-like domain of the oncogenic EWS-FLI1 fusion protein enables phase-separation events, which inappropriately recruit chromatin-remodeling factors to elicit the aberrant transcripti...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2017.09.010
更新日期:2017-09-21 00:00:00
abstract::Salmonella possesses several flagella, each capable of counterclockwise and clockwise rotation. Counterclockwise rotation produces swimming, clockwise rotation produces tumbling. Switching between senses occurs stochastically. The rotational sense of individual flagella on a single cell could be monitored under specia...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(83)90501-9
更新日期:1983-01-01 00:00:00
abstract::The major site of in vivo transcriptional initiation for both heavy and light strands of human mitochondrial DNA is the displacement-loop region. Transcripts synthesized in vitro by human mitochondrial RNA polymerase were mapped to the nucleotide level and have identical 5' end map positions to those reported for in v...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90343-x
更新日期:1984-03-01 00:00:00
abstract::torso encodes a receptor tyrosine kinase (torso) required for anterior and posterior terminal development of the Drosophila embryo. Injecting eggs with in vitro synthesized torso mRNAs revealed that torso activation is governed by an extracellular molecule, presumably the torso ligand, produced at terminal regions of ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90394-r
更新日期:1992-12-11 00:00:00
abstract::We have shown previously that the putative oncogene pim-1 is frequently activated by provirus insertion in murine leukemia virus-induced T cell lymphomas. Here we describe the structure of the pim-1 gene as determined by sequencing genomic and cDNA clones. The gene has an open reading frame, encoding a protein of 313 ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(86)90886-x
更新日期:1986-08-15 00:00:00
abstract::Long chain fatty acids (LCFAs) are an important energy substrate used by cardiac myocytes and other cells, but the mechanism whereby these molecules cross the plasma membrane is poorly understood. We used an expression cloning strategy and a cDNA library from 3T3-L1 adipocytes to identify a cDNA that, when expressed i...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(94)90252-6
更新日期:1994-11-04 00:00:00
abstract::Homology is an important feature of recombination. We have used the rll cistrons of bacteriophage T4 to determine the extent of homology required for recombination. We varied the amount of homologous DNA available for recombination in both marker rescue experiments and deletion-by-deletion crosses. Our results suggest...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90401-9
更新日期:1982-11-01 00:00:00
abstract::Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possible due to the rarity of these cells within tumor cell populations and their relative instability in culture. We describe here an approach to screening for agents with epithelial CSC-specific toxicity. We implemented this ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.06.034
更新日期:2009-08-21 00:00:00
abstract::Initiation of tumorigenesis in mouse skin can be accomplished by mutagenesis of the H-ras gene by treatment with chemical carcinogens. A mouse model system has been developed to study the additional genetic events that take place during tumor progression. Skin carcinomas were induced in F1 hybrid mice exhibiting restr...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90523-h
更新日期:1990-05-04 00:00:00
abstract::The bHLH-ZIP protein Mad heterodimerizes with Max as a sequence-specific transcriptional repressor. Mad is rapidly induced upon differentiation, and the associated switch from Myc-Max to Mad-Max heterocomplexes seem to repress genes normally activated by Myc-Max. We have identified two related mammalian cDNAs that enc...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90355-0
更新日期:1995-03-10 00:00:00
abstract::Rubisco, the key enzyme of CO2 fixation in photosynthesis, is prone to inactivation by inhibitory sugar phosphates. Inhibited Rubisco undergoes conformational repair by the hexameric AAA+ chaperone Rubisco activase (Rca) in a process that is not well understood. Here, we performed a structural and mechanistic analysis...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.09.010
更新日期:2020-10-15 00:00:00
abstract::The organization of neuronal systems is often dependent on activity and competition between cells. In olfaction, the X-linked OCNC1 channel subunit is subject to random inactivation and is essential for odorant-evoked activity. Reporter-tagged OCNC1 mutant mice permit the visualization of OCNC1-deficient olfactory neu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00262-8
更新日期:2001-03-09 00:00:00
abstract::The Wnt pathway controls cell fates, tissue homeostasis, and cancer. Its activation entails the association of beta-catenin with nuclear TCF/LEF proteins and results in transcriptional activation of target genes. The mechanism by which nuclear beta-catenin controls transcription is largely unknown. Here we genetically...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.01.053
更新日期:2006-04-21 00:00:00
abstract::Trypanosoma brucei variant surface glycoprotein (VSG) genes are activated either by duplicative (DA) transposition of the gene to a pre-activated expression site or by nonduplicative (NDA) activation of a previously silent telomeric gene. We have obtained a recombinant clone spanning the 5' barren region of the expres...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(85)80113-6
更新日期:1985-08-01 00:00:00
abstract::The primer transcript of plasmid ColE1 extends beyond the replication origin in either of two different modes. It does or does not form a hybrid with the template DNA. When a stretch of 20 deoxyadenosine residues is inserted into the template strand downstream of the origin, more than 90% of hybridized transcripts and...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90131-0
更新日期:1987-11-20 00:00:00
abstract::The mammalian alpha- and beta--globin genes are thought to have evolved from a common ancestral sequence by a duplication event that occurred over 500 million years ago. We have now determined the entire nucleotide sequence of a cloned mouse alpha--globin gene, including regions that flank and interrupt the coding seq...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(79)90139-9
更新日期:1979-11-01 00:00:00
abstract::Reactivation of human cytomegalovirus (HCMV) results in severe disease in AIDS patients and immunocompromised patients receiving blood transfusions or organ or bone marrow grafts. Although the site of HCMV latency is unknown, blood cells have been implicated as a viral reservoir. In this study, we demonstrate HCMV rea...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)80014-3
更新日期:1997-10-03 00:00:00
abstract::Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with over 370 structures in total bound to different ligands and the receptors in various conformational states. Structure-based drug design has been applied to an increasing number of GPCR targets over the past decade and now a few of t...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2020.03.003
更新日期:2020-04-02 00:00:00
abstract::Mammalian cells express a spectrum of tubulin isotypes whose relationship to the diversity of microtubule function is unknown. To examine whether different isotypes are segregated into functionally distinct microtubules, we generated immune sera capable of discriminating among the various naturally occurring beta-tubu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90456-9
更新日期:1987-05-22 00:00:00
abstract::The temperature-sensitive mutant of yeast, rna2-, when incubated at the nonpermissive temperature, has a qualitatively distinct distribution of mRNA sequences as compared to wild-type. Quantitative comparison with the wild-type distribution indicates that after 1 hr at the nonpermissive temperature, the concentration ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(77)90033-2
更新日期:1977-03-01 00:00:00
abstract::Condensin protein complexes coordinate the formation of mitotic chromosomes and thereby ensure the successful segregation of replicated genomes. Insights into how condensin complexes bind to chromosomes and alter their topology are essential for understanding the molecular principles behind the large-scale chromatin r...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.09.008
更新日期:2017-10-19 00:00:00
abstract::A recent report proposed a function of the ubiquitin conjugation factors Rad6 and Rad18 comparable to the bacterial SOS response, controlling damage-induced transcriptional activation and contributing to checkpoint signaling. The relevant ubiquitylation target was identified as budding yeast Rad17, a subunit of the PC...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2010.04.039
更新日期:2010-06-11 00:00:00
abstract::The trk tyrosine kinase proto-oncogene product gp140prototrk binds nerve growth factor (NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine whether gp140prototrk is involved in transducing a functional NGF signal, PC12 cell mutants (PC12nnr) deficient in high affinity NGF binding an...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90441-z
更新日期:1991-09-06 00:00:00
abstract::Cell-cell junctions respond to mechanical forces by changing their organization and function. To gain insight into the mechanochemical basis underlying junction mechanosensitivity, we analyzed tight junction (TJ) formation between the enveloping cell layer (EVL) and the yolk syncytial layer (YSL) in the gastrulating z...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.10.006
更新日期:2019-10-31 00:00:00
abstract::Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and chronically altering their activity also affects peripheral glucose homeostasis. We demonstrate that acute activation of AgRP neurons causes insulin resistance through impairment of insulin-stimulated glucose uptake into brown adipose t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.02.044
更新日期:2016-03-24 00:00:00
abstract::The peripheral nervous system has remarkable regenerative capacities in that it can repair a fully cut nerve. This requires Schwann cells to migrate collectively to guide regrowing axons across a 'bridge' of new tissue, which forms to reconnect a severed nerve. Here we show that blood vessels direct the migrating cord...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.07.021
更新日期:2015-08-27 00:00:00
abstract::Symbiotic bacteria are important in animal hosts, but have been largely overlooked as they have proved difficult to culture in the laboratory. Approaches such as comparative genomics and real-time PCR have provided insights into the molecular mechanisms that underpin symbiont-host interactions. Studies on the heritabl...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2006.07.014
更新日期:2006-08-11 00:00:00
abstract::Induction of pluripotency in somatic cells has been achieved by myriad combinations of transcription factors that belong to the core pluripotency circuitry. In this issue, Shu et al. report reprogramming with lineage specifiers, lending support to the view of the pluripotent state as a fine balance between competing d...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2013.04.051
更新日期:2013-05-23 00:00:00
abstract::TFIIH is a multisubunit protein complex that plays an essential role in nucleotide excision repair and transcription of protein-coding genes. Here, we report that TFIIH is also required for ribosomal RNA synthesis in vivo and in vitro. In yeast, pre-rRNA synthesis is impaired in TFIIH ts strains. In a mouse, part of c...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(02)00729-8
更新日期:2002-05-03 00:00:00