Molecular interactions between bacterial symbionts and their hosts.

abstract：:Coronavirus disease 2019 (COVID-19) is a novel respiratory illness caused by SARS-CoV-2. Viral entry is mediated through viral spike protein and host ACE2 enzyme interaction. Most cases are mild; severe disease often involves cytokine storm and organ failure. Therapeutics including antivirals, immunomodulators, and va...

journal_title：Cell

authors： Oberfeld B,Achanta A,Carpenter K,Chen P,Gilette NM,Langat P,Said JT,Schiff AE,Zhou AS,Barczak AK,Pillai S

更新日期：2020-05-14 00:00:00

abstract：:The membrane-bound form of immunoglobulin serves as an antigen-specific receptor for B cells mediating signal transduction and antigen presentation. We have developed an assay that reconstitutes both these physiologic responses with respect to the antigen phosphorylcholine. By introducing specific mutations in the hum...

journal_title：Cell

authors： Shaw AC,Mitchell RN,Weaver YK,Campos-Torres J,Abbas AK,Leder P

更新日期：1990-10-19 00:00:00

abstract：:Chemical cross-linking and DNA sequencing have revealed regions of intra-chromosomal interaction, referred to as topologically associating domains (TADs), interspersed with regions of little or no interaction, in interphase nuclei. We find that TADs and the regions between them correspond with the bands and interbands...

journal_title：Cell

authors： Eagen KP,Hartl TA,Kornberg RD

更新日期：2015-11-05 00:00:00

abstract：:The mechanism by which the membrane proteins of Sindbis virus are initially glycosylated during growth of the virus in chick cells was studied. The experiments suggest strongly that the two viral glycoproteins are glycosylated before release from the polysome, and that this glycosylation involves transfer of a large 1...

journal_title：Cell

authors： Sefton BM

更新日期：1977-04-01 00:00:00

abstract：:Chromosomal rearrangements, including translocations, require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are frequently involved in producing leukemias, lymphomas and sarcomas. Despite the importance of these events, current understanding of their gen...

journal_title：Cell

authors： Klein IA,Resch W,Jankovic M,Oliveira T,Yamane A,Nakahashi H,Di Virgilio M,Bothmer A,Nussenzweig A,Robbiani DF,Casellas R,Nussenzweig MC

更新日期：2011-09-30 00:00:00

abstract：:Recent studies suggest that local translation of mRNA within axons plays a key role in two aspects of growth cone navigation. One line of evidence implies a local synthesis of proteins that mediate growth cone collapse and turning in response to guidance cues; another indicates that growth cones possess the machinery ...

journal_title：Cell

authors： Steward O

更新日期：2002-09-06 00:00:00

abstract：:Rhythmic cardiac contractions depend on the organized propagation of depolarizing and repolarizing wavefronts. Repolarization is spatially heterogeneous and depends largely on gradients of potassium currents. Gradient disruption in heart disease may underlie susceptibility to fatal arrhythmias, but it is not known how...

journal_title：Cell

authors： Costantini DL,Arruda EP,Agarwal P,Kim KH,Zhu Y,Zhu W,Lebel M,Cheng CW,Park CY,Pierce SA,Guerchicoff A,Pollevick GD,Chan TY,Kabir MG,Cheng SH,Husain M,Antzelevitch C,Srivastava D,Gross GJ,Hui CC,Backx PH,Bruneau

更新日期：2005-10-21 00:00:00

abstract：:Competence development and sporulation in B. subtilis are partly controlled by peptides that accumulate in culture medium as cells grow to high density. We constructed two genes that encode mature forms of two different signaling molecules, the PhrA peptide that stimulates sporulation, and CSF, the competence- and spo...

journal_title：Cell

authors： Lazazzera BA,Solomon JM,Grossman AD

更新日期：1997-06-13 00:00:00

abstract：:The Polycomb group (Pc-G) proteins are responsible for keeping developmental regulators, like homeotic genes, stably and inheritably repressed during Drosophila development. Several similarities to a protein class involved in heterochromatin formation suggest that the Pc-G exerts its function at the higher order chrom...

journal_title：Cell

authors： Orlando V,Paro R

更新日期：1993-12-17 00:00:00

abstract：:We have isolated two adenylyl cyclase genes, designated ACA and ACG, from Dictyostelium. The proposed structure for ACA resembles that proposed for mammalian adenylyl cyclases: two large hydrophilic domains and two sets of six transmembrane spans. ACG has a novel structure, reminiscent of the membrane-bound guanylyl c...

journal_title：Cell

authors： Pitt GS,Milona N,Borleis J,Lin KC,Reed RR,Devreotes PN

更新日期：1992-04-17 00:00:00

abstract：:We investigated a herpesvirus mutant that contains a single base insertion in its thymidine kinase (tk) gene yet expresses low levels of TK via a net +1 translational recoding event. Within this mutant gene, we defined a G-rich signal that is sufficient to induce recoding. Unlike other translational recoding events, d...

journal_title：Cell

authors： Horsburgh BC,Kollmus H,Hauser H,Coen DM

更新日期：1996-09-20 00:00:00

abstract：:Strains of Saccharomyces that carry the nib allele of a nuclear gene exhibit a "nibbled" colony morphology if they also harbor the plasmid 2 mu DNA. I have found that the expression of the nibbled phenotype is correlated with the presence of a subpopulation of abnormally large cells that give rise to mortal clones. La...

journal_title：Cell

authors： Holm C

更新日期：1982-06-01 00:00:00

abstract：:DNA transposition has contributed significantly to evolution of eukaryotes and prokaryotes. Insertion sequences (ISs) are the simplest prokaryotic transposons and are divided into families on the basis of their organization and transposition mechanism. Here, we describe a link between transposition of IS608 and ISDra2...

journal_title：Cell

authors： Ton-Hoang B,Pasternak C,Siguier P,Guynet C,Hickman AB,Dyda F,Sommer S,Chandler M

更新日期：2010-08-06 00:00:00

abstract：:Microtubule-dependent motor, murine KIF3B, was disrupted by gene targeting. The null mutants did not survive beyond midgestation, exhibiting growth retardation, pericardial sac ballooning, and neural tube disorganization. Prominently, the left-right asymmetry was randomized in the heart loop and the direction of embry...

journal_title：Cell

authors： Nonaka S,Tanaka Y,Okada Y,Takeda S,Harada A,Kanai Y,Kido M,Hirokawa N

更新日期：1998-12-11 00:00:00

abstract：:Rho family GTPases are thought to regulate actin-dependent processes, but their functions in vivo are still poorly understood. We have investigated the function of a new, widely expressed Rho family member in C. elegans by analyzing mutations in the endogenous gene. Activated and null alleles all inhibit cell migratio...

journal_title：Cell

authors： Zipkin ID,Kindt RM,Kenyon CJ

更新日期：1997-09-05 00:00:00

abstract：:Molecular codes, like postal zip codes, are generally considered a robust way to ensure the specificity of neuronal target selection. However, a code capable of unambiguously generating complex neural circuits is difficult to conceive. Here, we re-examine the notion of molecular codes in the light of developmental alg...

journal_title：Cell

authors： Hassan BA,Hiesinger PR

更新日期：2015-10-08 00:00:00

abstract：:During development, sensory axons compete for limiting neurotrophic support, and local neurotrophin insufficiency triggers caspase-dependent axon degeneration. The signaling driving axon degeneration upon local deprivation is proposed to reside within axons. Our results instead support a model in which, despite the ap...

journal_title：Cell

authors： Simon DJ,Pitts J,Hertz NT,Yang J,Yamagishi Y,Olsen O,Tešić Mark M,Molina H,Tessier-Lavigne M

更新日期：2016-02-25 00:00:00

abstract：:Trigger factor is a soluble, 63,000 dalton protein of E. coli that stabilizes proOmpA, the precursor form of a major outer-membrane protein, in a conformation competent for in vitro membrane assembly. There is approximately one trigger factor molecule bound to each 70S ribosome isolated from cell extracts in physiolog...

journal_title：Cell

authors： Lill R,Crooke E,Guthrie B,Wickner W

更新日期：1988-09-23 00:00:00

abstract：:We report that the 12,000 dalton domain of fibronectin that interacts with fibroblast cell surfaces also binds specifically to thrombin-inducible, saturable receptors on platelets. Furthermore, we have used chemical cross-linking and monoclonal antibodies to show that the 12,000 dalton domain of fibronectin interacts ...

journal_title：Cell

authors： Gardner JM,Hynes RO

更新日期：1985-09-01 00:00:00

abstract：:The small molecular weight RNAs of the HeLa cell have been located in specific subcellular fractions. SnA is located in the nucleolus and is partially bonded to nucleolar 28S RNA. SnD, the most abundant of the small nuclear RNAs, is partially released from the nucleus when the nuclear preparation is briefly warmed. Sn...

journal_title：Cell

authors： Zieve G,Penman S

更新日期：1976-05-01 00:00:00

abstract：:It has been long appreciated that, during meiosis, DNA replication is coordinated with the subsequent formation of the double-strand breaks (DSBs) that initiate recombination, but a mechanistic understanding of this process was elusive. We now show that, in yeast, the replisome-associated components Tof1 and Csm3 phys...

journal_title：Cell

authors： Murakami H,Keeney S

更新日期：2014-08-14 00:00:00

abstract：:Mouse plasmacytoma (MOPC) 460 cells contain two chromatographic forms of RNA polymerase III (IIIA and IIIB) in addition to the major class I and II RNA polymerases. Nuclei isolated from these cells actively synthesize RNA. Among the discrete transcription products observed are the 5S and 4.5S RNAs and additional low m...

journal_title：Cell

authors： Sklar VE,Roeder RG

更新日期：1977-03-01 00:00:00

abstract：:Netrins are bifunctional: they attract some axons and repel others. Netrin receptors of the Deleted in Colorectal Cancer (DCC) family are implicated in attraction and those of the UNC5 family in repulsion, but genetic evidence also suggests involvement of the DCC protein UNC-40 in some cases of repulsion. To test whet...

journal_title：Cell

authors： Hong K,Hinck L,Nishiyama M,Poo MM,Tessier-Lavigne M,Stein E

更新日期：1999-06-25 00:00:00

abstract：:Transposon mutagenesis and complementation analysis of the photosynthesis genes in Rhodopseudomonas capsulata is presented utilizing Tn5.7 mutagenized R-primes. The R-prime pRPS404 contains many of the genes necessary for the differentiation of the photosynthetic apparatus. Utilizing homologous recombination, 30 indep...

journal_title：Cell

authors： Zsebo KM,Hearst JE

更新日期：1984-07-01 00:00:00

abstract：:TFIIH is a multisubunit protein complex that plays an essential role in nucleotide excision repair and transcription of protein-coding genes. Here, we report that TFIIH is also required for ribosomal RNA synthesis in vivo and in vitro. In yeast, pre-rRNA synthesis is impaired in TFIIH ts strains. In a mouse, part of c...

journal_title：Cell

authors： Iben S,Tschochner H,Bier M,Hoogstraten D,Hozák P,Egly JM,Grummt I

更新日期：2002-05-03 00:00:00

abstract：:Cell lines stably transfected with metal inducible, MT-fos chimeric genes were used to study the ability of the c-fos gene product, Fos, to act as a transcriptional trans-activator. In 3T3MTfos cells, induction of Fos expression led to specific trans-activation of an AP-1 responsive reporter gene. Induction of Fos exp...

journal_title：Cell

authors： Chiu R,Boyle WJ,Meek J,Smeal T,Hunter T,Karin M

更新日期：1988-08-12 00:00:00

abstract：:Viral infection causes the host to activate an antiviral response that, in part, is dependent on mitochondrial antiviral signaling protein (MAVS) to stimulate type I interferons. Zhang et al. (2019) demonstrate that glucose-generated lactate interacts with MAVS to suppress type I interferons. This study links glucose ...

journal_title：Cell

authors： Stoolman JS,Chandel NS

更新日期：2019-06-27 00:00:00

abstract：:Negative selection with FUdR produced revertants from the transformed rat line 14B, which contains one insertion of the SV40 viral genome (Botchan, Topp and Sambrook, 1976). 14B contains nuclear T antigen, grows to a high density, grows in low serum and is anchorage-independent. The revertants fall into three classes ...

journal_title：Cell

authors： Steinberg B,Pollack R,Topp W,Botchan M

更新日期：1978-01-01 00:00:00

abstract：:Metazoan evolution involves increasing protein domain complexity, but how this relates to control of biological decisions remains uncertain. The Ras guanine nucleotide exchange factor (RasGEF) Sos1 and its adaptor Grb2 are multidomain proteins that couple fibroblast growth factor (FGF) signaling to activation of the R...

journal_title：Cell

authors： Findlay GM,Smith MJ,Lanner F,Hsiung MS,Gish GD,Petsalaki E,Cockburn K,Kaneko T,Huang H,Bagshaw RD,Ketela T,Tucholska M,Taylor L,Bowtell DD,Moffat J,Ikura M,Li SS,Sidhu SS,Rossant J,Pawson T

更新日期：2013-02-28 00:00:00

abstract：:Francis' office window (at the Salk) commanded a panorama of the Pacific. "This grand natural scene was a physical correlate of Francis's intellectual world: wide-ranging, brilliantly lit, a little overawing, but also immensely inviting and above all an exciting place to be." (Mitchison, 2004). ...

journal_title：Cell

authors： Lawrence PA

更新日期：2016-12-01 00:00:00