Abstract：
:TFIIH is a multisubunit protein complex that plays an essential role in nucleotide excision repair and transcription of protein-coding genes. Here, we report that TFIIH is also required for ribosomal RNA synthesis in vivo and in vitro. In yeast, pre-rRNA synthesis is impaired in TFIIH ts strains. In a mouse, part of cellular TFIIH is localized within the nucleolus and is associated with subpopulations of both RNA polymerase I and the basal factor TIF-IB. Transcription systems lacking TFIIH are inactive and exogenous TFIIH restores transcriptional activity. TFIIH is required for productive but not abortive rDNA transcription, implying a postinitiation role in transcription. The results provide a molecular link between RNA polymerase I transcription and transcription-coupled repair of active ribosomal RNA genes.
journal_name
Celljournal_title
Cellauthors
Iben S,Tschochner H,Bier M,Hoogstraten D,Hozák P,Egly JM,Grummt Idoi
10.1016/s0092-8674(02)00729-8subject
Has Abstractpub_date
2002-05-03 00:00:00pages
297-306issue
3eissn
0092-8674issn
1097-4172pii
S0092867402007298journal_volume
109pub_type
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