Abstract:
:Two key events in Wnt signal transduction, receptor endocytosis and inactivation of Glycogen Synthase Kinase 3 (GSK3), remain incompletely understood. Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a new framework for understanding Wnt signaling.
journal_name
Celljournal_title
Cellauthors
Niehrs C,Acebron SPdoi
10.1016/j.cell.2010.12.003subject
Has Abstractpub_date
2010-12-23 00:00:00pages
1044-6issue
7eissn
0092-8674issn
1097-4172pii
S0092-8674(10)01421-2journal_volume
143pub_type
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