Abstract:
:The enteric bacteria Salmonella typhimurium has the ability to invade (enter) nonphagocytic cells. The internalization process occurs as a result of an intimate interaction between the bacteria and the host cell, in which S. typhimurium triggers a cascade of host cell-signaling events leading to the formation of host cell membrane ruffles and bacterial uptake. Using high resolution scanning electron microscopy, we have observed that contact with cultured epithelial cells results in the formation of appendages on the surface of S. typhimurium. The formation of such appendages did not require de novo protein synthesis, and it was transient, since these surface structures were no longer present on bacteria that had initiated the internalization event. Salmonella mutants defective in the transient formation of these surface organelles were unable to enter into cultured epithelial cells, indicating that such structures are required for bacterial internalization.
journal_name
Celljournal_title
Cellauthors
Ginocchio CC,Olmsted SB,Wells CL,Galán JEdoi
10.1016/0092-8674(94)90510-xsubject
Has Abstractpub_date
1994-02-25 00:00:00pages
717-24issue
4eissn
0092-8674issn
1097-4172pii
0092-8674(94)90510-Xjournal_volume
76pub_type
杂志文章相关文献
CELL文献大全abstract::NPR1 is an essential regulator of plant systemic acquired resistance (SAR), which confers immunity to a broad-spectrum of pathogens. SAR induction results in accumulation of the signal molecule salicylic acid (SA), which induces defense gene expression via activation of NPR1. We found that in an uninduced state, NPR1 ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(03)00429-x
更新日期:2003-06-27 00:00:00
abstract::Nuclear exclusion of the forkhead transcription factor FOXO3a by protein kinase Akt contributes to cell survival. We investigated the pathological relationship between phosphoylated-Akt (Akt-p) and FOXO3a in primary tumors. Surprisingly, FOXO3a was found to be excluded from the nuclei of some tumors lacking Akt-p, sug...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(04)00302-2
更新日期:2004-04-16 00:00:00
abstract::The messenger RNA coding for the precursor of the small subunit of ribulose--1,5--bisphosphate (Ru-P2) carboxylase has been partially purified from pea leaves. The mRNA has a size of 11.5S, is approximately 800 nucleotides long and, on cell-free translation, directs the synthesis of a single major polypeptide of 20,00...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(79)90164-8
更新日期:1979-06-01 00:00:00
abstract::The LIM domain protein rbtn2 is associated with T cell acute leukemias. We demonstrate that rbtn2 is a nuclear protein expressed in the erythroid lineage in vivo, and using homologous recombination, we show that it is essential for erythroid development in mice. The homozygous rbtn2 null mutation leads to failure of y...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(94)90571-1
更新日期:1994-07-15 00:00:00
abstract::Plants greatly rely on their root microbiome for uptake of nutrients and protection against stresses. Recent studies have uncovered the involvement of plant stress responses in the assembly of plant-beneficial microbiomes. To facilitate durable crop production, deciphering the driving forces that shape the microbiome ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.02.024
更新日期:2018-03-08 00:00:00
abstract::p11, through unknown mechanisms, is required for behavioral and cellular responses to selective serotonin reuptake inhibitors (SSRIs). We show that SMARCA3, a chromatin-remodeling factor, is a target for the p11/annexin A2 heterotetrameric complex. Determination of the crystal structure indicates that SMARCA3 peptide ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.01.014
更新日期:2013-02-14 00:00:00
abstract::Five single base pair mutations that increase expression of the tnpA (transposase) gene of the Tn3 transposon approximately 30-fold, but which still allow the gene to be regulated, have been isolated by using a generally applicable procedure that involves distally linked lac gene fusions. The mutations, which are all ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90352-x
更新日期:1982-02-01 00:00:00
abstract::In Saccharomyces cerevisiae, known histone acetylation sites regulating gene activity are located in the N-terminal tails protruding from the nucleosome core. We report lysine 56 in histone H3 as a novel acetylation site that is located in the globular domain, where it extends toward the DNA major groove at the entry-...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2005.03.011
更新日期:2005-05-06 00:00:00
abstract::This paper describes a model for the structure of DNA contained in three morphologically similar bacteriophages--T7, P22 and phiCd-1--based on the transient electric dichroism of intact phage. The reduced dichroism of each of the phages at perfect orientation is within the range +0.12 to +0.19. Assuming that the phage...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(79)90026-6
更新日期:1979-03-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death worldwide. We report in an emphysema model of mice chronically exposed to tobacco smoke that pulmonary vascular dysfunction, vascular remodeling, and pulmonary hypertension (PH) precede development of alveolar destruction. We provid...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2011.08.035
更新日期:2011-10-14 00:00:00
abstract::The ubiquitin-specific processing protease (UBP) family of deubiquitinating enzymes plays an essential role in numerous cellular processes. HAUSP, a representative UBP, specifically deubiquitinates and hence stabilizes the tumor suppressor protein p53. Here, we report the crystal structures of the 40 kDa catalytic cor...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(02)01199-6
更新日期:2002-12-27 00:00:00
abstract::Nuclear hormone receptors comprise a superfamily of ligand-modulated transcription factors that mediate the transcriptional activities of steroids, retinoids, and thyroid hormones. A growing number of related proteins have been identified that possess the structural features of hormone receptors, but that lack known l...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90530-8
更新日期:1995-06-02 00:00:00
abstract::The inhibitor of apoptosis (IAP) proteins suppress cell death by inhibiting the catalytic activity of caspases. Here we present the crystal structure of caspase-7 in complex with a potent inhibitory fragment from XIAP at 2.45 A resolution. An 18-residue XIAP peptide binds the catalytic groove of caspase-7, making exte...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00272-0
更新日期:2001-03-09 00:00:00
abstract::From the approximately 1,200 odorant receptor (OR) genes in the mouse genome, an olfactory sensory neuron is thought to express only one gene. The mechanisms of OR gene choice are not understood. A 2.1 kilobase region (the H element) adjacent to a cluster of seven OR genes has been proposed as a trans- and pan-enhance...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.06.023
更新日期:2007-07-27 00:00:00
abstract::As more plant genome sequences become available, researchers are increasingly using comparative genomics to address some of the major questions in plant biology. Such questions include the evolution of photosynthesis and multicellularity, the developmental genetic changes responsible for alterations in body plan, and ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.04.004
更新日期:2007-04-20 00:00:00
abstract::The dual host range virus HIX has been previously characterized as an envelope gene recombinant between Moloney murine leukemia virus (Mo-MuLV) and an unidentified xenotropic murine leukemia virus. Using long reverse transcripts of Mo-MuLV, a region of nonhomology has been mapped by electron microscopic analysis of he...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(78)90350-1
更新日期:1978-08-01 00:00:00
abstract::The Ras GTPase links extracellular mitogens to intracellular mechanisms that control cell proliferation. To understand how Ras regulates proliferation in vivo, we activated or inactivated Ras in cell clones in the developing Drosophila wing. Cells lacking Ras were smaller, had reduced growth rates, accumulated in G1, ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80679-0
更新日期:2000-02-18 00:00:00
abstract::Polycomb group (PcG) proteins form large multimeric complexes (PcG bodies) which are involved in the stable repression of gene expression. The human PcG protein, Pc2, has been shown to recruit the transcriptional corepressor, CtBP, to PcG bodies. We show that CtBP is sumoylated at a single lysine. In vitro, CtBP sumoy...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(03)00159-4
更新日期:2003-04-04 00:00:00
abstract::Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro; however, the role of RBC dehydration in protection against malaria in vivo is unknown. Most cases of hereditary xer...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.02.047
更新日期:2018-04-05 00:00:00
abstract::Post-translational modifications of histone proteins and exchanges of histone variants of chromatin are central to the regulation of nearly all DNA-templated biological processes. However, the degree and variability of chromatin modifications in specific human immune cells remain largely unknown. Here, we employ a hig...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.03.079
更新日期:2018-05-31 00:00:00
abstract::Chromatin assembly factor 1 (CAF-1) and Rtt106 participate in the deposition of newly synthesized histones onto replicating DNA to form nucleosomes. This process is critical for the maintenance of genome stability and inheritance of functionally specialized chromatin structures in proliferating cells. However, the mol...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2008.06.018
更新日期:2008-07-25 00:00:00
abstract::Activation of the cyclin-dependent kinases to promote cell cycle progression requires their association with cyclins as well as phosphorylation of a threonine (residue 161 in human p34cdc2). This phosphorylation is carried out by CAK, the Cdk-activating kinase. We have purified and cloned CAK from S. cerevisiae. Unlik...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80129-4
更新日期:1996-08-23 00:00:00
abstract::Previous experiments have shown that mRNA translation in frog oocytes can be inhibited by the injection of a complementary antisense RNA. Here we explore the use of antisense RNAs to study the functions of localized maternal mRNAs during postfertilization development. While developmental abnormalities were observed in...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90238-8
更新日期:1987-02-27 00:00:00
abstract::The steroid hormone ecdysone triggers coordinate changes in Drosophila tissue development that result in metamorphosis. To advance our understanding of the genetic regulatory hierarchies controlling this tissue response, we have isolated and characterized a gene, EcR, for a new steroid receptor homolog and have shown ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90572-g
更新日期:1991-10-04 00:00:00
abstract::Social isolation is a stressful condition that often leads to maladaptive behaviors. In this issue of Cell, Zelikowsky et al. find that chronic social isolation stress triggers an increase in neuronal tachykinin signaling across distinct brain regions that mediate fear and aggression, elucidating the neural basis of t...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2018.04.031
更新日期:2018-05-17 00:00:00
abstract::Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken. Among identified targets was BCL2, whose germline deletion produces melanocyte loss and w...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(02)00762-6
更新日期:2002-06-14 00:00:00
abstract::The ephrin/Eph system plays a central role in neuronal circuit formation; however, its downstream effectors are poorly understood. Here we show that alpha-chimerin Rac GTPase-activating protein mediates ephrinB3/EphA4 forward signaling. We discovered a spontaneous mouse mutation, miffy (mfy), which results in a rabbit...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.07.022
更新日期:2007-08-24 00:00:00
abstract::The yeast [PSI+] factor is inherited by a prion mechanism involving self-propagating Sup35p aggregates. We find that Sup35p prion function is conserved among distantly related yeasts. As with mammalian prions, a species barrier inhibits prion induction between Sup35p from different yeast species. This barrier is faith...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81565-2
更新日期:2000-01-21 00:00:00
abstract::Monkey cell lines that constitutively synthesize 38.6 kd lac repressor protein and bear stably integrated chloramphenicol acetyl transferase (CAT) genes linked to a lac operator-containing SV40 early promoter-enhancer were generated. When grown in medium containing isopropyl beta-D-thiogalactoside (IPTG), these cells ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(88)90409-6
更新日期:1988-03-11 00:00:00
abstract::Heat shock and other proteotoxic stresses cause accumulation of nonnative proteins that trigger activation of heat shock protein (Hsp) genes. A chaperone/Hsp functioning as repressor of heat shock transcription factor (HSF) could make activation of hsp genes dependent on protein unfolding. In a novel in vitro system, ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81588-3
更新日期:1998-08-21 00:00:00