当前位置： SCI文献检索 > CELL期刊下所有文献 > The polycomb protein Pc2 is a SUMO E3.

The polycomb protein Pc2 is a SUMO E3.

Abstract：

:Polycomb group (PcG) proteins form large multimeric complexes (PcG bodies) which are involved in the stable repression of gene expression. The human PcG protein, Pc2, has been shown to recruit the transcriptional corepressor, CtBP, to PcG bodies. We show that CtBP is sumoylated at a single lysine. In vitro, CtBP sumoylation minimally requires the SUMO E1 and E2 (Ubc9) and SUMO-1. However, Pc2 dramatically enhances CtBP sumoylation. In vivo, this is likely due to the ability of Pc2 to recruit both CtBP and Ubc9 to PcG bodies, thereby bringing together substrate and E2, and stimulating the transfer of SUMO to CtBP. These results demonstrate that Pc2 is a SUMO E3, and suggest that PcG bodies may be sumoylation centers.

journal_name

Cell

journal_title

Cell

authors

Kagey MH,Melhuish TA,Wotton D

doi

10.1016/s0092-8674(03)00159-4

subject

Has Abstract

pub_date

2003-04-04 00:00:00

pages

127-37

issue

1

eissn

0092-8674

issn

1097-4172

pii

S0092867403001594

journal_volume

113

pub_type

杂志文章

相关文献

CELL文献大全
  • Pattern abnormalities induced by ectopic expression of the Drosophila gene hairy are associated with repression of ftz transcription.

    abstract：:The pair-rule segmentation gene hairy (h) is expressed and required in alternate metameres in the early Drosophila embryo. We show that h expression outside these domains, driven by an hsp70 promoter, suppresses the expression of fushi tarazu (ftz). The kinetics of action favor h acting directly as a transcriptional r...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(87)90636-2

    authors： Ish-Horowicz D,Pinchin SM

    更新日期：1987-11-06 00:00:00

  • Negative control of the helix-loop-helix family of myogenic regulators in the NFB mutant.

    abstract：:We have characterized a nondifferentiating mouse muscle cell line, NFB, that represses the activity of the helix-loop-helix (HLH) family of myogenic regulators, yet expresses sarcomeric actins. The NFB MyoD gene is silent, but can be activated upon transfection of a long terminal region-controlled chicken MyoD cDNA, r...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(90)90014-6

    authors： Peterson CA,Gordon H,Hall ZW,Paterson BM,Blau HM

    更新日期：1990-08-10 00:00:00

  • Autoregulation of 2 micron circle gene expression provides a model for maintenance of stable plasmid copy levels.

    abstract：:The yeast plasmid 2 micron circle actively maintains high but stable copy levels in the cell, even though the plasmid confers no selective advantage to its host. To address the mechanism by which stable copy control is achieved, we have examined the level of expression of the genes resident on the yeast plasmid 2 micr...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(88)90528-4

    authors： Som T,Armstrong KA,Volkert FC,Broach JR

    更新日期：1988-01-15 00:00:00

  • DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension.

    abstract：:DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retr...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.cell.2015.08.005

    authors： Licht JD

    更新日期：2015-08-27 00:00:00

  • Endosome-specific localization and function of the ARF activator GNOM.

    abstract：:ARF GTPases act at multiple steps of the secretory and vacuolar/lysosomal trafficking pathways, but little is known about the spatial regulation of ARF activation. In this issue of Cell, Geldner et al. demonstrate that the Arabidopsis ARF activator GNOM localizes to endosomes where it controls the polarized traffickin...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/s0092-8674(03)00038-2

    authors： Bonifacino JS,Jackson CL

    更新日期：2003-01-24 00:00:00

  • Social Isolation Co-opts Fear and Aggression Circuits.

    abstract：:Social isolation is a stressful condition that often leads to maladaptive behaviors. In this issue of Cell, Zelikowsky et al. find that chronic social isolation stress triggers an increase in neuronal tachykinin signaling across distinct brain regions that mediate fear and aggression, elucidating the neural basis of t...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.cell.2018.04.031

    authors： Rodriguez-Romaguera J,Stuber GD

    更新日期：2018-05-17 00:00:00

  • Differential postendocytotic compartmentation in Xenopus oocytes is mediated by a specifically bound ligand.

    abstract：:Xenopus laevis oocytes were used as a model system to study the intracellular fate of proteins incorporated by endocytosis. We found that the intracellular stability and compartmentation of proteins incorporated by receptor-mediated endocytosis differed substantially from that of proteins incorporated by nonspecific e...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(80)90153-1

    authors： Opresko L,Wiley HS,Wallace RA

    更新日期：1980-11-01 00:00:00

  • Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning.

    abstract：:Observational learning is a powerful survival tool allowing individuals to learn about threat-predictive stimuli without directly experiencing the pairing of the predictive cue and punishment. This ability has been linked to the anterior cingulate cortex (ACC) and the basolateral amygdala (BLA). To investigate how inf...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2018.04.004

    authors： Allsop SA,Wichmann R,Mills F,Burgos-Robles A,Chang CJ,Felix-Ortiz AC,Vienne A,Beyeler A,Izadmehr EM,Glober G,Cum MI,Stergiadou J,Anandalingam KK,Farris K,Namburi P,Leppla CA,Weddington JC,Nieh EH,Smith AC,Ba D,Bro

    更新日期：2018-05-31 00:00:00

  • Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein.

    abstract：:X-linked lissencephaly and "double cortex" are allelic human disorders mapping to Xq22.3-Xq23 associated with arrest of migrating cerebral cortical neurons. We identified a novel 10 kb brain-specific cDNA interrupted by a balanced translocation in an XLIS patient that encodes a novel 40 kDa predicted protein named Dou...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(00)80899-5

    authors： Gleeson JG,Allen KM,Fox JW,Lamperti ED,Berkovic S,Scheffer I,Cooper EC,Dobyns WB,Minnerath SR,Ross ME,Walsh CA

    更新日期：1998-01-09 00:00:00

  • A cellular gene encodes scrapie PrP 27-30 protein.

    abstract：:A clone encoding PrP 27-30, the major protein in purified preparations of scrapie agent, was selected from a scrapie-infected hamster brain cDNA library by oligonucleotide probes corresponding to the N terminus of the protein. Southern blotting with PrP cDNA revealed a single gene with the same restriction patterns in...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(85)90333-2

    authors： Oesch B,Westaway D,Wälchli M,McKinley MP,Kent SB,Aebersold R,Barry RA,Tempst P,Teplow DB,Hood LE

    更新日期：1985-04-01 00:00:00

  • Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse.

    abstract：:The auditory inner hair cell (IHC) ribbon synapse operates with an exceptional temporal precision and maintains a high level of neurotransmitter release. However, the molecular mechanisms underlying IHC synaptic exocytosis are largely unknown. We studied otoferlin, a predicted C2-domain transmembrane protein, which is...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2006.08.040

    authors： Roux I,Safieddine S,Nouvian R,Grati M,Simmler MC,Bahloul A,Perfettini I,Le Gall M,Rostaing P,Hamard G,Triller A,Avan P,Moser T,Petit C

    更新日期：2006-10-20 00:00:00

  • Folding and trimerization of clathrin subunits at the triskelion hub.

    abstract：:The triskelion shape of the clathrin molecule enables it to form the polyhedral protein network that covers clathrin-coated pits and vesicles. Domains within the clathrin heavy chain that are responsible for maintaining triskelion shape and function were identified and localized. Sequences that mediate trimerization a...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(92)90033-9

    authors： Näthke IS,Heuser J,Lupas A,Stock J,Turck CW,Brodsky FM

    更新日期：1992-03-06 00:00:00

  • The bacterial toxin RelE displays codon-specific cleavage of mRNAs in the ribosomal A site.

    abstract：:The Escherichia coli relBE operon encodes a toxin-antitoxin pair, RelE-RelB. RelB can reverse inhibition of protein synthesis by RelE in vivo. We have found that although RelE does not degrade free RNA, it cleaves mRNA in the ribosomal A site with high codon specificity. Among stop codons UAG is cleaved with fast, UAA...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(02)01248-5

    authors： Pedersen K,Zavialov AV,Pavlov MY,Elf J,Gerdes K,Ehrenberg M

    更新日期：2003-01-10 00:00:00

  • TIGAR, a p53-inducible regulator of glycolysis and apoptosis.

    abstract：:The p53 tumor-suppressor protein prevents cancer development through various mechanisms, including the induction of cell-cycle arrest, apoptosis, and the maintenance of genome stability. We have identified a p53-inducible gene named TIGAR (TP53-induced glycolysis and apoptosis regulator). TIGAR expression lowered fruc...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2006.05.036

    authors： Bensaad K,Tsuruta A,Selak MA,Vidal MN,Nakano K,Bartrons R,Gottlieb E,Vousden KH

    更新日期：2006-07-14 00:00:00

  • Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif.

    abstract：:An essential yeast protein, Nup145p, is identified via its genetic interaction with the nucleoporin Nsp1p. Nup145p contains GLFG repeats and localizes to nuclear pores. Depletion of Nup145p in vivo leads rapidly to nuclear retention of polyadenylated RNAs and more slowly to cytoplasmic accumulation of a nuclear report...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(94)90297-6

    authors： Fabre E,Boelens WC,Wimmer C,Mattaj IW,Hurt EC

    更新日期：1994-07-29 00:00:00

  • Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.

    abstract：:Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken. Among identified targets was BCL2, whose germline deletion produces melanocyte loss and w...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(02)00762-6

    authors： McGill GG,Horstmann M,Widlund HR,Du J,Motyckova G,Nishimura EK,Lin YL,Ramaswamy S,Avery W,Ding HF,Jordan SA,Jackson IJ,Korsmeyer SJ,Golub TR,Fisher DE

    更新日期：2002-06-14 00:00:00

  • Separation of endocytic from exocytic coated vesicles using a novel cholinesterase mediated density shift technique.

    abstract：:Coated vesicles isolated from rat liver perfused with diisopropylfluorophosphate (DFP) to inactivate endogenous cholinesterase contained newly synthesized secretory cholinesterase after a 30 min recovery. The cholinesterase is found in coated vesicles of presumed endocytic origin following DFP treatment and perfusion ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(86)90471-x

    authors： Helmy S,Porter-Jordan K,Dawidowicz EA,Pilch P,Schwartz AL,Fine RE

    更新日期：1986-02-14 00:00:00

  • A kinesin-like protein is required for germ plasm aggregation in Xenopus.

    abstract：:In embryos of X. laevis, and many other species, early development requires targeted movements of molecules and molecular aggregates within the oocyte or egg cytoplasm. One well-known example in Xenopus is the aggregation of germ plasm, a group of cytoplasmic islands that become distributed during the first few cell c...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(00)81990-x

    authors： Robb DL,Heasman J,Raats J,Wylie C

    更新日期：1996-11-29 00:00:00

  • Mating signals control expression of mutations resulting from insertion of a transposable repetitive element adjacent to diverse yeast genes.

    abstract：:ROAM mutations cause overproduction in S. cerevisiae. Overproduction of ROAM mutant gene products is less in MATa/MAT alpha diploid strains which cannot conjugate than in haplolid strains which can. Overproduction occurs in diploid strains capable of mating whether or not they are capable of sporulating. Overproductio...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(80)90353-0

    authors： Errede B,Cardillo TS,Sherman F,Dubois E,Deschamps J,Wiame JM

    更新日期：1980-11-01 00:00:00

  • Rejuvenating exhausted T cells during chronic viral infection.

    abstract：:In a recent paper in Nature, show that the immunoreceptor PD-1 is upregulated by "exhausted" T cells during the chronic phase of viral infection in mice. Remarkably, blocking the interaction between PD-1 and its ligand, PD-L1, reactivates these T cells and reduces viral load. ...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.cell.2006.01.022

    authors： Okazaki T,Honjo T

    更新日期：2006-02-10 00:00:00

  • DNAase I sensitivity and methylation of active versus inactive rRNA genes in xenopus species hybrids.

    abstract：:We studied the chromatin structure and methylation of ribosomal RNA genes (rDNA) in hybrids between Xenopus laevis and Xenopus borealis. S1-nuclease protection experiments showed that 97%-98% of the rRNA precursor in hybrid tadpoles was of the X. laevis type. Preferential expression of the laevis rDNA was correlated w...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(82)90105-2

    authors： Macleod D,Bird A

    更新日期：1982-05-01 00:00:00

  • The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

    abstract：:Histone methylation regulates chromatin structure and transcription. The recently identified histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to demethylation of only mono- and di- but not trimethylated histone H3 lysine 4 (H3K4me3). We show that the X-linked mental retardation (XLMR) ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2007.02.017

    authors： Iwase S,Lan F,Bayliss P,de la Torre-Ubieta L,Huarte M,Qi HH,Whetstine JR,Bonni A,Roberts TM,Shi Y

    更新日期：2007-03-23 00:00:00

  • Adaptation in bacterial chemotaxis: CheB-dependent modification permits additional methylations of sensory transducer proteins.

    abstract：:Sensory transduction in E. coli consists of two phases, excitation and adaptation, both of which involve the methyl-accepting chemotaxis proteins (MCPs). These molecules relay transmembrane signals and are reversibly methylated during adaptation of E. coli to environmental stimuli. Each MCP contains multiple sites of ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(82)90438-x

    authors： Kehry MR,Dahlquist FW

    更新日期：1982-07-01 00:00:00

  • Powered by gas--a ligand for a fruit fly nuclear receptor.

    abstract：:The difficulty in identifying ligands for nuclear hormone receptors remains an obstacle to understanding their function. For example, in the fruit fly Drosophila melanogaster, only one of its nuclear receptors has a known ligand. In this issue of Cell, report that the fruit fly E75 nuclear receptor contains heme in it...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.cell.2005.07.007

    authors： Thummel CS

    更新日期：2005-07-29 00:00:00

  • A dispersed multigene family encoding tubulin in Drosophila melanogaster.

    abstract：:We have used cloned chicken cDNA sequences for alpha- and beta-tubulin to investigate tubulin gene organization in Drosophila melanogaster. Experiments using genomic Drosophila DNA from several sources indicate that there are at least four copies each of the alpha-tubulin gene and the beta-tubulin gene. In situ hybrid...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(80)90561-9

    authors： Sánchez F,Natzle JE,Cleveland DW,Kirschner MW,McCarthy BJ

    更新日期：1980-12-01 00:00:00

  • Multiscale Structuring of the E. coli Chromosome by Nucleoid-Associated and Condensin Proteins.

    abstract：:As in eukaryotes, bacterial genomes are not randomly folded. Bacterial genetic information is generally carried on a circular chromosome with a single origin of replication from which two replication forks proceed bidirectionally toward the opposite terminus region. Here, we investigate the higher-order architecture o...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2017.12.027

    authors： Lioy VS,Cournac A,Marbouty M,Duigou S,Mozziconacci J,Espéli O,Boccard F,Koszul R

    更新日期：2018-02-08 00:00:00

  • Swaying is a mutant allele of the proto-oncogene Wnt-1.

    abstract：:Mice homozygous for the recessive mutation swaying (sw) are characterized by ataxia and hypertonia, attributed to the malformation of anterior regions of the cerebellum. We show that sw is a deletion of a single base pair from the proto-oncogene Wnt-1. The deletion is predicted to cause premature termination of transl...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(91)90369-a

    authors： Thomas KR,Musci TS,Neumann PE,Capecchi MR

    更新日期：1991-11-29 00:00:00

  • PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.

    abstract：:The transcription factor ATF2 elicits oncogenic activities in melanoma and tumor suppressor activities in nonmalignant skin cancer. Here, we identify that ATF2 tumor suppressor function is determined by its ability to localize at the mitochondria, where it alters membrane permeability following genotoxic stress. The a...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2012.01.016

    authors： Lau E,Kluger H,Varsano T,Lee K,Scheffler I,Rimm DL,Ideker T,Ronai ZA

    更新日期：2012-02-03 00:00:00

  • PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.

    abstract：:Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors that play critical roles in thrombosis, inflammation, and vascular biology. PAR1 is proposed to be involved in the invasive and metastatic processes of various cancers. However, the protease responsible for activating the proinvasive...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2004.12.018

    authors： Boire A,Covic L,Agarwal A,Jacques S,Sherifi S,Kuliopulos A

    更新日期：2005-02-11 00:00:00

  • Organization of the ribosomal RNA genes of Dictyostelium discoideum: mapping of the nontranscribed spacer regions.

    abstract：:Most of the Dictyostelium ribosomal nontranscribed spacer DNA has been mapped using Eco R1, Hind III, and Sal I restriction digests and recombinant plasmids containing parts of the rDNA (ribosomal DNA). The repeat units are at least 42 kb (1 kilobase = 1000 base pairs = 1 kb) long; of this, 8 kb codes for the 36S rRNA...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(76)90043-x

    authors： Cockburn AF,Newkirk MJ,Firtel RA

    更新日期：1976-12-01 00:00:00