Powered by gas--a ligand for a fruit fly nuclear receptor.

Abstract:

:The difficulty in identifying ligands for nuclear hormone receptors remains an obstacle to understanding their function. For example, in the fruit fly Drosophila melanogaster, only one of its nuclear receptors has a known ligand. In this issue of Cell, report that the fruit fly E75 nuclear receptor contains heme in its ligand binding pocket and that the oxidation state of this molecule controls E75 activity. They also show that E75-heme responds to the small diatomic gases, nitric oxide and carbon monoxide. This study sheds light on how heme, gas signaling, and nuclear receptors interact to control metabolic and developmental pathways.

journal_name

Cell

journal_title

Cell

authors

Thummel CS

doi

10.1016/j.cell.2005.07.007

subject

Has Abstract

pub_date

2005-07-29 00:00:00

pages

151-3

issue

2

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(05)00700-2

journal_volume

122

pub_type

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