Abstract:
:The difficulty in identifying ligands for nuclear hormone receptors remains an obstacle to understanding their function. For example, in the fruit fly Drosophila melanogaster, only one of its nuclear receptors has a known ligand. In this issue of Cell, report that the fruit fly E75 nuclear receptor contains heme in its ligand binding pocket and that the oxidation state of this molecule controls E75 activity. They also show that E75-heme responds to the small diatomic gases, nitric oxide and carbon monoxide. This study sheds light on how heme, gas signaling, and nuclear receptors interact to control metabolic and developmental pathways.
journal_name
Celljournal_title
Cellauthors
Thummel CSdoi
10.1016/j.cell.2005.07.007subject
Has Abstractpub_date
2005-07-29 00:00:00pages
151-3issue
2eissn
0092-8674issn
1097-4172pii
S0092-8674(05)00700-2journal_volume
122pub_type
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