Organization of the ribosomal RNA genes of Dictyostelium discoideum: mapping of the nontranscribed spacer regions.

abstract：:Nuclear matrices from undifferentiated and differentiated Friend erythroleukemia cells have been obtained by a method which removes DNA in a physiological buffer. These matrices preserved the characteristic topographical distribution of condensed and diffuse "chromatin" regions, as do nuclei in situ or isolated nuclei...

journal_title：Cell

authors： Long BH,Huang CY,Pogo AO

更新日期：1979-12-01 00:00:00

abstract：:Mice homozygous for the recessive mutation swaying (sw) are characterized by ataxia and hypertonia, attributed to the malformation of anterior regions of the cerebellum. We show that sw is a deletion of a single base pair from the proto-oncogene Wnt-1. The deletion is predicted to cause premature termination of transl...

journal_title：Cell

authors： Thomas KR,Musci TS,Neumann PE,Capecchi MR

更新日期：1991-11-29 00:00:00

abstract：:A key function of blood vessels, to supply oxygen, is impaired in tumors because of abnormalities in their endothelial lining. PHD proteins serve as oxygen sensors and may regulate oxygen delivery. We therefore studied the role of endothelial PHD2 in vessel shaping by implanting tumors in PHD2(+/-) mice. Haplodeficien...

journal_title：Cell

authors： Mazzone M,Dettori D,de Oliveira RL,Loges S,Schmidt T,Jonckx B,Tian YM,Lanahan AA,Pollard P,de Almodovar CR,De Smet F,Vinckier S,Aragonés J,Debackere K,Luttun A,Wyns S,Jordan B,Pisacane A,Gallez B,Lampugnani MG,Dej

更新日期：2009-03-06 00:00:00

abstract：:Following DNA replication, eukaryotic cells must biorient all sister chromatids prior to cohesion cleavage at anaphase. In animal cells, sister chromatids gradually biorient during prometaphase, but current models of mitosis in S. cerevisiae assume that biorientation is established shortly after S phase. This assumpti...

journal_title：Cell

authors： Marco E,Dorn JF,Hsu PH,Jaqaman K,Sorger PK,Danuser G

更新日期：2013-08-29 00:00:00

abstract：:Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These states are associated w...

journal_title：Cell

authors： Imamovic L,Ellabaan MMH,Dantas Machado AM,Citterio L,Wulff T,Molin S,Krogh Johansen H,Sommer MOA

更新日期：2018-01-11 00:00:00

abstract：:A recent report proposed a function of the ubiquitin conjugation factors Rad6 and Rad18 comparable to the bacterial SOS response, controlling damage-induced transcriptional activation and contributing to checkpoint signaling. The relevant ubiquitylation target was identified as budding yeast Rad17, a subunit of the PC...

journal_title：Cell

authors： Davies AA,Neiss A,Ulrich HD

更新日期：2010-06-11 00:00:00

abstract：:We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transc...

journal_title：Cell

authors： Sonigo P,Alizon M,Staskus K,Klatzmann D,Cole S,Danos O,Retzel E,Tiollais P,Haase A,Wain-Hobson S

更新日期：1985-08-01 00:00:00

abstract：:RNA polymerase II (RNAPII) lies at the core of dynamic control of gene expression. Using 53 RNAPII point mutants, we generated a point mutant epistatic miniarray profile (pE-MAP) comprising ∼60,000 quantitative genetic interactions in Saccharomyces cerevisiae. This analysis enabled functional assignment of RNAPII subd...

journal_title：Cell

authors： Braberg H,Jin H,Moehle EA,Chan YA,Wang S,Shales M,Benschop JJ,Morris JH,Qiu C,Hu F,Tang LK,Fraser JS,Holstege FC,Hieter P,Guthrie C,Kaplan CD,Krogan NJ

更新日期：2013-08-15 00:00:00

abstract：:The Ion gene of E. coli controls the stability of two bacteriophage lambda proteins. The functional half-life of the phage N gene product, measured by complementation, is increased about 5-fold in Ion mutant strains, from 2 min to 10 min. The chemical half-life of N protein, determined by its disappearance on polyacry...

journal_title：Cell

authors： Gottesman S,Gottesman M,Shaw JE,Pearson ML

更新日期：1981-04-01 00:00:00

abstract：:Trigger factor is a soluble, 63,000 dalton protein of E. coli that stabilizes proOmpA, the precursor form of a major outer-membrane protein, in a conformation competent for in vitro membrane assembly. There is approximately one trigger factor molecule bound to each 70S ribosome isolated from cell extracts in physiolog...

journal_title：Cell

authors： Lill R,Crooke E,Guthrie B,Wickner W

更新日期：1988-09-23 00:00:00

abstract：:The monoclonal antibody ECCD-1 inhibits Ca2+-dependent cell-cell adhesion in teratocarcinoma cells, recognizing a cell surface component of MW 124,000. When mouse embryos at various preimplantation stages were cultured in the presence of ECCD-1, the compacted morphology of the 8- to 16-cell-stage embryos was destroyed...

journal_title：Cell

authors： Shirayoshi Y,Okada TS,Takeichi M

更新日期：1983-12-01 00:00:00

abstract：:Epigenetic inheritance is more widespread in plants than in mammals, in part because mammals erase epigenetic information by germline reprogramming. We sequenced the methylome of three haploid cell types from developing pollen: the sperm cell, the vegetative cell, and their precursor, the postmeiotic microspore, and f...

journal_title：Cell

authors： Calarco JP,Borges F,Donoghue MT,Van Ex F,Jullien PE,Lopes T,Gardner R,Berger F,Feijó JA,Becker JD,Martienssen RA

更新日期：2012-09-28 00:00:00

abstract：:Adult neovascularization relies on the recruitment of circulating cells, but their angiogenic roles and recruitment mechanisms are unclear. We show that the endothelial growth factor VEGF is sufficient for organ homing of circulating mononuclear myeloid cells and is required for their perivascular positioning and rete...

journal_title：Cell

authors： Grunewald M,Avraham I,Dor Y,Bachar-Lustig E,Itin A,Jung S,Chimenti S,Landsman L,Abramovitch R,Keshet E

更新日期：2006-01-13 00:00:00

abstract：:On each side of the midline of the Drosophila CNS, axons are organized into a series of parallel pathways. Here we show that the midline repellent Slit, previously identified as a short-range signal that regulates midline crossing, also functions at long range to pattern these longitudinal pathways. In this long-range...

journal_title：Cell

authors： Rajagopalan S,Vivancos V,Nicolas E,Dickson BJ

更新日期：2000-12-22 00:00:00

abstract：:Based on the above mechanisms of mRNA degradation, an integrated model of mRNA turnover can be proposed (Figure 1). In this model, all polyadenylated mRNAs would be degraded by the deadenylation-dependent pathway at some rate. In addition to this default pathway, another layer of complexity would come from degradation...

journal_title：Cell

authors： Beelman CA,Parker R

更新日期：1995-04-21 00:00:00

abstract：:Individual olfactory sensory neurons express only a single odorant receptor from a large family of genes, and this singularity is an essential feature in models of olfactory perception. We have devised a genetic strategy to examine the stability of receptor choice. We observe that immature olfactory sensory neurons th...

journal_title：Cell

authors： Shykind BM,Rohani SC,O'Donnell S,Nemes A,Mendelsohn M,Sun Y,Axel R,Barnea G

更新日期：2004-06-11 00:00:00

abstract：:O(2) is the ultimate electron acceptor for mitochondrial respiration, a process catalyzed by cytochrome c oxidase (COX). In yeast, COX subunit composition is regulated by COX5a and COX5b gene transcription in response to high and low O(2), respectively. Here we demonstrate that in mammalian cells, expression of the CO...

journal_title：Cell

authors： Fukuda R,Zhang H,Kim JW,Shimoda L,Dang CV,Semenza GL

更新日期：2007-04-06 00:00:00

abstract：:Molecular chaperones assist protein folding by facilitating their "forward" folding and preventing aggregation. However, once aggregates have formed, these chaperones cannot facilitate protein disaggregation. Bacterial ClpB and its eukaryotic homolog Hsp104 are essential proteins of the heat-shock response, which have...

journal_title：Cell

authors： Lee S,Sowa ME,Watanabe YH,Sigler PB,Chiu W,Yoshida M,Tsai FT

更新日期：2003-10-17 00:00:00

abstract：:The mammalian circadian timing system is composed of a central pacemaker in the suprachiasmatic nucleus (SCN) of the brain and subsidiary oscillators in most peripheral cell types. While oscillators in SCN neurons are known to function in a self-sustained fashion, peripheral oscillators have been thought to damp rapid...

journal_title：Cell

authors： Nagoshi E,Saini C,Bauer C,Laroche T,Naef F,Schibler U

更新日期：2004-11-24 00:00:00

abstract：:Using X-ray crystallography, we have directly observed the path of mRNA in the 70S ribosome in Fourier difference maps at 7 A resolution. About 30 nucleotides of the mRNA are wrapped in a groove that encircles the neck of the 30S subunit. The Shine-Dalgarno helix is bound in a large cleft between the head and the back...

journal_title：Cell

authors： Yusupova GZ,Yusupov MM,Cate JH,Noller HF

更新日期：2001-07-27 00:00:00

abstract：:The mechanisms by which immune checkpoint blockade modulates tumor evolution during therapy are unclear. We assessed genomic changes in tumors from 68 patients with advanced melanoma, who progressed on ipilimumab or were ipilimumab-naive, before and after nivolumab initiation (CA209-038 study). Tumors were analyzed by...

journal_title：Cell

authors： Riaz N,Havel JJ,Makarov V,Desrichard A,Urba WJ,Sims JS,Hodi FS,Martín-Algarra S,Mandal R,Sharfman WH,Bhatia S,Hwu WJ,Gajewski TF,Slingluff CL Jr,Chowell D,Kendall SM,Chang H,Shah R,Kuo F,Morris LGT,Sidhom JW,Sch

更新日期：2017-11-02 00:00:00

abstract：:The mRNAs from two yeast mitochondrial genes cob-box (cytochrome b) and oxi-3 (cytochrome oxidase 40,000 dalton subunit) are processed from large (7-10 kb) precursors. Certain mutations in each gene block the maturation of the RNAs from both genes at a variety of specific steps. The pleiotropic cytochrome b mutants se...

journal_title：Cell

authors： Church GM,Slonimski PP,Gilbert W

更新日期：1979-12-01 00:00:00

abstract：:beta-glucocerebrosidase, the enzyme defective in Gaucher disease, is targeted to the lysosome independently of the mannose-6-phosphate receptor. Affinity-chromatography experiments revealed that the lysosomal integral membrane protein LIMP-2 is a specific binding partner of beta-glucocerebrosidase. This interaction in...

journal_title：Cell

authors： Reczek D,Schwake M,Schröder J,Hughes H,Blanz J,Jin X,Brondyk W,Van Patten S,Edmunds T,Saftig P

更新日期：2007-11-16 00:00:00

abstract：:Can a heterotrophic organism be evolved to synthesize biomass from CO2 directly? So far, non-native carbon fixation in which biomass precursors are synthesized solely from CO2 has remained an elusive grand challenge. Here, we demonstrate how a combination of rational metabolic rewiring, recombinant expression, and lab...

journal_title：Cell

authors： Antonovsky N,Gleizer S,Noor E,Zohar Y,Herz E,Barenholz U,Zelcbuch L,Amram S,Wides A,Tepper N,Davidi D,Bar-On Y,Bareia T,Wernick DG,Shani I,Malitsky S,Jona G,Bar-Even A,Milo R

更新日期：2016-06-30 00:00:00

abstract：:Upon exposure to 0.1 mM N-phosphonacetyl-L-aspartate (PALA), a transition state analog inhibitor of aspartate transcarbamylase, most cells of a simian virus 40 (SV40)-transformed Syrian hamster line are killed within a few days, but resistant mutants form spontaneously with frequency 2-5 X 10(-5) in a stochastic proce...

journal_title：Cell

authors： Kempe TD,Swyryd EA,Bruist M,Stark GR

更新日期：1976-12-01 00:00:00

abstract：:The hemagglutinin of influenza virus is synthesized as a monomeric subunit that is cotranslationally translocated across the membrane of the rough endoplasmic reticulum. We show that folding and assembly of hemagglutinin monomers into trimeric structures takes approximately 7-10 min and is completed before the protein...

journal_title：Cell

authors： Gething MJ,McCammon K,Sambrook J

更新日期：1986-09-12 00:00:00

abstract：:Lipid biology continues to emerge as an area of significant therapeutic interest, particularly as the result of an enhanced understanding of the wealth of signaling molecules with diverse physiological properties. This growth in knowledge is epitomized by lysophosphatidic acid (LPA), which functions through interactio...

journal_title：Cell

authors： Chrencik JE,Roth CB,Terakado M,Kurata H,Omi R,Kihara Y,Warshaviak D,Nakade S,Asmar-Rovira G,Mileni M,Mizuno H,Griffith MT,Rodgers C,Han GW,Velasquez J,Chun J,Stevens RC,Hanson MA

更新日期：2015-06-18 00:00:00

abstract：:In this study, we have located the sites of transcription initiation and termination on a cloned fragment of ribosomal DNA from X. laevis, and have sequenced the surrounding nucleotides. As reported previously (Reeder, Sollner-Webb and Wahn, 1977), about 25% of the 40S rRNA precursor molecules isolated from oocytes ha...

journal_title：Cell

authors： Sollner-Webb B,Reeder RH

更新日期：1979-10-01 00:00:00

abstract：:Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequen...

journal_title：Cell

authors： Volz E,Hill V,McCrone JT,Price A,Jorgensen D,O'Toole Á,Southgate J,Johnson R,Jackson B,Nascimento FF,Rey SM,Nicholls SM,Colquhoun RM,da Silva Filipe A,Shepherd J,Pascall DJ,Shah R,Jesudason N,Li K,Jarrett R,Pacchi

更新日期：2021-01-07 00:00:00

abstract：:Partially edited mRNAs were selected by the polymerase chain reaction and sequenced. In the case of cytochrome b, 102 out of 106 clones displayed patterns of editing that were consistent with a strictly progressive 3' to 5' editing process, as predicted by the guide RNA model of RNA editing. In the case of cytochrome ...

journal_title：Cell

authors： Sturm NR,Simpson L

更新日期：1990-06-01 00:00:00