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Gene switching and the stability of odorant receptor gene choice.

Abstract：

:Individual olfactory sensory neurons express only a single odorant receptor from a large family of genes, and this singularity is an essential feature in models of olfactory perception. We have devised a genetic strategy to examine the stability of receptor choice. We observe that immature olfactory sensory neurons that express a given odorant receptor can switch receptor expression, albeit at low frequency. Neurons that express a mutant receptor gene switch receptor transcription with significantly greater probability, suggesting that the expression of a functional odorant receptor elicits a feedback signal that terminates switching. This process of receptor gene switching assures that a neuron will ultimately express a functional receptor and that the choice of this receptor will remain stable for the life of the cell.

journal_name

Cell

journal_title

Cell

authors

Shykind BM,Rohani SC,O'Donnell S,Nemes A,Mendelsohn M,Sun Y,Axel R,Barnea G

doi

10.1016/j.cell.2004.05.015

subject

Has Abstract

pub_date

2004-06-11 00:00:00

pages

801-15

issue

6

eissn

0092-8674

issn

1097-4172

pii

S009286740400529X

journal_volume

117

pub_type

杂志文章

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