Plasticity of the Electrical Connectome of C. elegans.

abstract：:Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death worldwide. We report in an emphysema model of mice chronically exposed to tobacco smoke that pulmonary vascular dysfunction, vascular remodeling, and pulmonary hypertension (PH) precede development of alveolar destruction. We provid...

journal_title：Cell

authors： Seimetz M,Parajuli N,Pichl A,Veit F,Kwapiszewska G,Weisel FC,Milger K,Egemnazarov B,Turowska A,Fuchs B,Nikam S,Roth M,Sydykov A,Medebach T,Klepetko W,Jaksch P,Dumitrascu R,Garn H,Voswinckel R,Kostin S,Seeger W,S

更新日期：2011-10-14 00:00:00

abstract：:We report genome-wide DNA data for 73 individuals from five archaeological sites across the Bronze and Iron Ages Southern Levant. These individuals, who share the "Canaanite" material culture, can be modeled as descending from two sources: (1) earlier local Neolithic populations and (2) populations related to the Chal...

journal_title：Cell

authors： Agranat-Tamir L,Waldman S,Martin MAS,Gokhman D,Mishol N,Eshel T,Cheronet O,Rohland N,Mallick S,Adamski N,Lawson AM,Mah M,Michel M,Oppenheimer J,Stewardson K,Candilio F,Keating D,Gamarra B,Tzur S,Novak M,Kalisher R

更新日期：2020-05-28 00:00:00

abstract：:The heterotrimeric Sec61p complex is a major component of the protein-conducting channel of the endoplasmic reticulum (ER) membrane, associating with either ribosomes or the Sec62/63 complex to perform co- and posttranslational transport, respectively. We show by electron microscopy that purified mammalian and yeast S...

journal_title：Cell

authors： Hanein D,Matlack KE,Jungnickel B,Plath K,Kalies KU,Miller KR,Rapoport TA,Akey CW

更新日期：1996-11-15 00:00:00

abstract：:The chromosomal distributions of five families of mouse r-protein genes (S16, L18, L19, L30 and L32/33) were studied by Southern blot analysis of DNa from a panel of mouse-hamster hybrid cells containing various complements of mouse chromosomes. Our results indicated that members of a particular family are often locat...

journal_title：Cell

authors： D'Eustachio P,Meyuhas O,Ruddle F,Perry RP

更新日期：1981-05-01 00:00:00

abstract：:Transcription hinders replication fork progression and stability. The ATR checkpoint and specialized DNA helicases assist DNA synthesis across transcription units to protect genome integrity. Combining genomic and genetic approaches together with the analysis of replication intermediates, we searched for factors coord...

journal_title：Cell

authors： Alzu A,Bermejo R,Begnis M,Lucca C,Piccini D,Carotenuto W,Saponaro M,Brambati A,Cocito A,Foiani M,Liberi G

更新日期：2012-11-09 00:00:00

abstract：:A basic B-cell-specific protein of 35,000 daltons (XM1) is expressed at a high rate--comparable to actin--in resting splenic B lymphocytes of various species. Splenic or thymic T cells or fibroblasts do not express this protein. Upon polyclonal stimulation of B lymphocytes or in proliferating B-lymphocyte-derived cell...

journal_title：Cell

authors： Rahmsdorf HJ,Mallick U,Ponta H,Herrlich P

更新日期：1982-06-01 00:00:00

abstract：:Microglia are the resident macrophages of the CNS, and their functions have been extensively studied in various brain pathologies. The physiological roles of microglia in brain plasticity and function, however, remain unclear. To address this question, we generated CX3CR1(CreER) mice expressing tamoxifen-inducible Cre...

journal_title：Cell

authors： Parkhurst CN,Yang G,Ninan I,Savas JN,Yates JR 3rd,Lafaille JJ,Hempstead BL,Littman DR,Gan WB

更新日期：2013-12-19 00:00:00

abstract：:Protein-tyrosine phosphatases (PTPs), along with protein-tyrosine kinases, play key roles in cellular signaling. All Class I PTPs contain an essential active site cysteinyl residue, which executes a nucleophilic attack on substrate phosphotyrosyl residues. The high reactivity of the catalytic cysteine also predisposes...

journal_title：Cell

authors： Karisch R,Fernandez M,Taylor P,Virtanen C,St-Germain JR,Jin LL,Harris IS,Mori J,Mak TW,Senis YA,Östman A,Moran MF,Neel BG

更新日期：2011-09-02 00:00:00

abstract：:Methylation of deoxycytidine incorporated by DNA excision-repair was studied in human diploid fibroblasts following damage with ultraviolet radiation, N-methyl-N-nitrosourea, or N-acetoxy-2-acetylaminofluorene. In confluent, nondividing cells, methylation in repair patches induced by all three agents is slow and incom...

journal_title：Cell

authors： Kastan MB,Gowans BJ,Lieberman MW

更新日期：1982-09-01 00:00:00

abstract：:To guide the design of immunotherapy strategies for patients with early stage lung tumors, we developed a multiscale immune profiling strategy to map the immune landscape of early lung adenocarcinoma lesions to search for tumor-driven immune changes. Utilizing a barcoding method that allows a simultaneous single-cell ...

journal_title：Cell

authors： Lavin Y,Kobayashi S,Leader A,Amir ED,Elefant N,Bigenwald C,Remark R,Sweeney R,Becker CD,Levine JH,Meinhof K,Chow A,Kim-Shulze S,Wolf A,Medaglia C,Li H,Rytlewski JA,Emerson RO,Solovyov A,Greenbaum BD,Sanders C,Vi

更新日期：2017-05-04 00:00:00

abstract：:Interactions between similar but not identical (homeologous) DNA sequences play an important biological role in the evolution of genes and genomes. To gain insight into the underlying molecular mechanism(s) of genetic recombination, we have studied inter- and intramolecular homeologous recombination in S. cerevisiae d...

journal_title：Cell

authors： Mézard C,Pompon D,Nicolas A

更新日期：1992-08-21 00:00:00

abstract：:Nuclear and cytoplasmic poly(A)-binding proteins have been purified from Saccharomyces cerevisiae, and antisera have been used to isolate a gene that encodes them. The gene occurs in a single copy on chromosome 5 and gives rise to a unique, unspliced 2.1 kb transcript. The nuclear protein appears to be derived from th...

journal_title：Cell

authors： Sachs AB,Bond MW,Kornberg RD

更新日期：1986-06-20 00:00:00

abstract：:Use-dependent synapse remodeling is thought to provide a cellular mechanism for encoding durable memories, yet whether activity triggers an actual structural change has remained controversial. We use photoconductive stimulation to demonstrate activity-dependent morphological synaptic plasticity by video imaging of GFP...

journal_title：Cell

authors： Colicos MA,Collins BE,Sailor MJ,Goda Y

更新日期：2001-11-30 00:00:00

abstract：:Deletion analysis was carried out on the human 7SK RNA gene to map regions essential for in vitro transcription by RNA polymerase III. The sequence promoting transcription is located between 37 and 3 bp upstream of the 7SK RNA coding region. RNA polymerase III transcription of adjacent plasmid sequences can be directe...

journal_title：Cell

authors： Murphy S,Di Liegro C,Melli M

更新日期：1987-10-09 00:00:00

abstract：:Suppressor of Hairless [Su(H)]/Lag-1/RBP-Jkappa/CBF1 is the only known transducing transcription factor for Notch receptor signaling. Here, we show that Su(H) has three distinct functions in the development of external mechanosensory organs in Drosophila: Notch-dependent transcriptional activation and a novel auto-rep...

journal_title：Cell

authors： Barolo S,Walker RG,Polyanovsky AD,Freschi G,Keil T,Posakony JW

更新日期：2000-12-08 00:00:00

abstract：:Forskolin- and cholera toxin-activated adenylate cyclase activity increases between the morula and blastocyst stages of mouse preimplantation development, as assessed by the ability of these agents to increase embryonic cAMP levels. Development of activatable adenylate cyclase requires transcription but is independent...

journal_title：Cell

authors： Manejwala F,Kaji E,Schultz RM

更新日期：1986-07-04 00:00:00

abstract：:I have defined conditions under which RepFIC plasmid DNA can be maintained in a state of lowered helical density. In exponentially growing cultures, the DNA of lowered helical density is present in small amounts but never totally absent, suggesting that it is a normal variant of plasmid maintenance. It is fully methyl...

journal_title：Cell

authors： Maas R

更新日期：2001-06-29 00:00:00

abstract：:Using insertional mutagenesis, we have isolated a "stalky" mutant in which cells destined to become spores end up as stalk cells. Similar mutants were previously observed after chemical mutagenesis, but the affected gene could not be isolated. Our mutant, like the previous ones, is in stkA. Its defect is cell-autonomo...

journal_title：Cell

authors： Chang WT,Newell PC,Gross JD

更新日期：1996-11-01 00:00:00

abstract：:The temperature-sensitive mutant of yeast, rna2-, when incubated at the nonpermissive temperature, has a qualitatively distinct distribution of mRNA sequences as compared to wild-type. Quantitative comparison with the wild-type distribution indicates that after 1 hr at the nonpermissive temperature, the concentration ...

journal_title：Cell

authors： Hereford LM,Rosbash M

更新日期：1977-03-01 00:00:00

abstract：:The endoplasmic reticulum (ER) often forms stacked membrane sheets, an arrangement that is likely required to accommodate a maximum of membrane-bound polysomes for secretory protein synthesis. How sheets are stacked is unknown. Here, we used improved staining and automated ultrathin sectioning electron microscopy meth...

journal_title：Cell

authors： Terasaki M,Shemesh T,Kasthuri N,Klemm RW,Schalek R,Hayworth KJ,Hand AR,Yankova M,Huber G,Lichtman JW,Rapoport TA,Kozlov MM

更新日期：2013-07-18 00:00:00

abstract：:Dysfunctional mitochondria accumulate in many human diseases. Accordingly, mitophagy, which removes these mitochondria through lysosomal degradation, is attracting broad attention. Due to uncertainties in the operational principles of conventional mitophagy probes, however, the specificity and quantitativeness of thei...

journal_title：Cell

authors： Katayama H,Hama H,Nagasawa K,Kurokawa H,Sugiyama M,Ando R,Funata M,Yoshida N,Homma M,Nishimura T,Takahashi M,Ishida Y,Hioki H,Tsujihata Y,Miyawaki A

更新日期：2020-05-28 00:00:00

abstract：:Sirtuins are thought to form crucial links between energy levels and cellular metabolism. Libert et al. now provide evidence that SIRT1 activity in the brain modifies mammalian emotional behavior via monoamine signaling and that changes in this pathway might contribute to human affective disorders. ...

journal_title：Cell

authors： Drew LJ,Hen R

更新日期：2011-12-23 00:00:00

abstract：:Telomeres are thought to be maintained by the preferential recruitment of telomerase to the shortest telomeres. The extension of the G-rich telomeric strand by telomerase is also believed to be coordinated with the complementary synthesis of the C strand by the conventional replication machinery. However, we show that...

journal_title：Cell

authors： Zhao Y,Sfeir AJ,Zou Y,Buseman CM,Chow TT,Shay JW,Wright WE

更新日期：2009-08-07 00:00:00

abstract：:Homology is an important feature of recombination. We have used the rll cistrons of bacteriophage T4 to determine the extent of homology required for recombination. We varied the amount of homologous DNA available for recombination in both marker rescue experiments and deletion-by-deletion crosses. Our results suggest...

journal_title：Cell

authors： Singer BS,Gold L,Gauss P,Doherty DH

更新日期：1982-11-01 00:00:00

abstract：:Exposure to Mycobacterium tuberculosis produces varied early outcomes, ranging from resistance to infection to progressive disease. Here we report results from a forward genetic screen in zebrafish larvae that identify multiple mutant classes with distinct patterns of innate susceptibility to Mycobacterium marinum. A ...

journal_title：Cell

authors： Tobin DM,Vary JC Jr,Ray JP,Walsh GS,Dunstan SJ,Bang ND,Hagge DA,Khadge S,King MC,Hawn TR,Moens CB,Ramakrishnan L

更新日期：2010-03-05 00:00:00

abstract：:Extraction of glycerinated chicken skeletal muscle with 0.6 M potassium iodide leaves a framework of insoluble components within each muscle fiber. This framework is composed primarily of planes of in-register Z discs that have been thickened by the accumulation of material on both sides of each disc during extraction...

journal_title：Cell

authors： Granger BL,Lazarides E

更新日期：1978-12-01 00:00:00

abstract：:Plant seedling development is capable of following 1 of 2 distinct morphogenic pathways: skotomorphogenesis in darkness and photomorphogenesis in light. Dark-grown Arabidopsis seedlings with recessive mutations at the constitutively photomorphogenic (COP1) locus indicate that the wild-type COP1 protein represses photo...

journal_title：Cell

authors： Deng XW,Matsui M,Wei N,Wagner D,Chu AM,Feldmann KA,Quail PH

更新日期：1992-11-27 00:00:00

abstract：:Cyclic dinucleotides (CDNs) play central roles in bacterial pathogenesis and innate immunity. The mammalian enzyme cGAS synthesizes a unique cyclic dinucleotide (cGAMP) containing a 2'-5' phosphodiester linkage essential for optimal immune stimulation, but the molecular basis for linkage specificity is unknown. Here, ...

journal_title：Cell

authors： Kranzusch PJ,Lee ASY,Wilson SC,Solovykh MS,Vance RE,Berger JM,Doudna JA

更新日期：2014-08-28 00:00:00

abstract：:The modulation of cell metabolism by cell shape and external surface contact has been studied by suspension culture of anchorage-dependent fibroblasts. The suspended cells shut down protein synthesis and nuclear RNA metabolism and cease replicating DNA. However, these responses to suspension are lost or modified as ce...

journal_title：Cell

authors： Wittelsberger SC,Kleene K,Penman S

更新日期：1981-06-01 00:00:00

abstract：:The enteric bacteria Salmonella typhimurium has the ability to invade (enter) nonphagocytic cells. The internalization process occurs as a result of an intimate interaction between the bacteria and the host cell, in which S. typhimurium triggers a cascade of host cell-signaling events leading to the formation of host ...

journal_title：Cell

authors： Ginocchio CC,Olmsted SB,Wells CL,Galán JE

更新日期：1994-02-25 00:00:00