Abstract:
:Plant seedling development is capable of following 1 of 2 distinct morphogenic pathways: skotomorphogenesis in darkness and photomorphogenesis in light. Dark-grown Arabidopsis seedlings with recessive mutations at the constitutively photomorphogenic (COP1) locus indicate that the wild-type COP1 protein represses photomorphogenesis in darkness and that light reverses this repressive activity. Using a T-DNA-tagged mutant, we have cloned the COP1 locus. The amino-terminal half of the encoded protein contains a conserved zinc-binding motif, whereas the carboxyl-terminal half contains a domain homologous to the WD-40 repeat motif of G beta proteins. The presence of both a putative DNA-binding motif and a G protein-related domain in a single polypeptide suggests that COP1 may be the first of a new class of regulatory molecules. This novel structure could endow COP1 with the capacity to function as a negative transcriptional regulator capable of direct interaction with components of the G protein signaling pathway.
journal_name
Celljournal_title
Cellauthors
Deng XW,Matsui M,Wei N,Wagner D,Chu AM,Feldmann KA,Quail PHdoi
10.1016/0092-8674(92)90555-qsubject
Has Abstractpub_date
1992-11-27 00:00:00pages
791-801issue
5eissn
0092-8674issn
1097-4172pii
0092-8674(92)90555-Qjournal_volume
71pub_type
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