Abstract:
:To defend cells against viruses, the MAVS (mitochondrial antiviral signaling) adaptor protein initiates an antiviral signaling cascade from mitochondrial membranes. In this issue, Dixit et al. (2010) show that MAVS also localizes to the membranes of peroxisomes, where it rapidly induces expression of a subset of antiviral genes that curb viral replication until mitochondrial MAVS can induce a sustained antiviral response.
journal_name
Celljournal_title
Cellauthors
Sharma S,Fitzgerald KAdoi
10.1016/j.cell.2010.04.043subject
Has Abstractpub_date
2010-05-14 00:00:00pages
570-2issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(10)00497-6journal_volume
141pub_type
评论,杂志文章相关文献
CELL文献大全abstract::P-selectin binding to neutrophils requires a specific protein, P-selectin glycoprotein ligand 1 (PSGL-1), as well as sialyl-Lewis X (sLex) glycan determinants. We have found that a short segment near the amino terminus of PSGL-1 that contains a tyrosine sulfation consensus is essential for P-selectin adhesion and that...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90174-4
更新日期:1995-10-20 00:00:00
abstract::Pancreatic beta cell-surface expression of glucose transporter 2 (Glut-2) is essential for glucose-stimulated insulin secretion, thereby controlling blood glucose homeostasis in response to dietary intake. We show that the murine GlcNAcT-IVa glycosyltransferase is required for Glut-2 residency on the beta cell surface...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2005.09.041
更新日期:2005-12-29 00:00:00
abstract::The RNA helicase eIF4A plays a key role in unwinding of mRNA and scanning during translation initiation. Free eIF4A is a poor helicase and requires the accessory proteins eIF4G and eIF4H. However, the structure of the helicase complex and the mechanisms of stimulation of eIF4A activity have remained elusive. Here we r...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.01.014
更新日期:2009-02-06 00:00:00
abstract::Social isolation is a stressful condition that often leads to maladaptive behaviors. In this issue of Cell, Zelikowsky et al. find that chronic social isolation stress triggers an increase in neuronal tachykinin signaling across distinct brain regions that mediate fear and aggression, elucidating the neural basis of t...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2018.04.031
更新日期:2018-05-17 00:00:00
abstract::Abiotic stress, such as salinity, drought, and cold, causes detrimental yield losses for all major plant crop species. Understanding mechanisms that improve plants' ability to produce biomass, which largely is constituted by the plant cell wall, is therefore of upmost importance for agricultural activities. Cellulose ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.08.028
更新日期:2015-09-10 00:00:00
abstract::Synapse formation requires changes in cell morphology and the upregulation and localization of synaptic proteins. In the cerebellum, mossy fibers undergo extensive remodeling as they contact several granule cells and form complex, multisynaptic glomerular rosettes. Here we show that granule cells secrete factors that ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80689-3
更新日期:2000-03-03 00:00:00
abstract::During RNA interference (RNAi), Dicer generates short interfering RNAs (siRNAs), which then guide target mRNA cleavage by the RISC complex. Now, Liu et al. identify R2D2, a Dicer-associated protein that is important for siRNA incorporation into RISC, thus linking the initiation and execution phases of RNAi. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(03)00806-7
更新日期:2003-10-17 00:00:00
abstract::G1-specific transcriptional activation by Cln3/CDK initiates the budding yeast cell cycle. To identify targets of Cln3/CDK, we analyzed the SBF and MBF transcription factor complexes by multidimensional protein interaction technology (MudPIT). Whi5 was identified as a stably bound component of SBF but not MBF. Inactiv...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2004.05.025
更新日期:2004-06-25 00:00:00
abstract::Chromosomal translocations between antigen receptor loci and oncogenes are a hallmark of lymphoid cancers. Several new studies now reveal that programmed DNA breaks created during assembly of antigen receptor genes can be channeled into an alternative DNA end-joining pathway that is implicated in the chromosomal trans...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.10.005
更新日期:2007-10-19 00:00:00
abstract::Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation, cellular differentiation, and development. However, the mechanisms by which these complexes recognize their target sites and function together to form repressive chromatin domains remain po...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.05.004
更新日期:2014-06-05 00:00:00
abstract::A general strategy is described for the isolation of suppressors of essential genes whose functions are unknown. This strategy was used to analyze the role of 4.5S RNA, an essential RNA of E. coli. In this strategy, the structural gene for 4.5S RNA is fused to the Ptac promoter in such a way that the strain becomes de...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90620-9
更新日期:1987-06-19 00:00:00
abstract::The intestinal microbiota produces tens of thousands of metabolites. Here, we used host sensing of small molecules by G-protein coupled receptors (GPCRs) as a lens to illuminate bioactive microbial metabolites that impact host physiology. We screened 144 human gut bacteria against the non-olfactory GPCRome and identif...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.03.036
更新日期:2019-05-16 00:00:00
abstract::Filamentous invasive growth of S. cerevisiae requires multiple elements of the mitogen-activated protein kinase (MAPK) signaling cascade that are also components of the mating pheromone response pathway. Here we show that, despite sharing several constituents, the two pathways use different MAP kinases. The Fus3 MAPK ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80454-7
更新日期:1997-11-28 00:00:00
abstract::Protein kinase C (PKC) isozymes have remained elusive cancer targets despite the unambiguous tumor promoting function of their potent ligands, phorbol esters, and the prevalence of their mutations. We analyzed 8% of PKC mutations identified in human cancers and found that, surprisingly, most were loss of function and ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.01.001
更新日期:2015-01-29 00:00:00
abstract::Recent studies suggest that local translation of mRNA within axons plays a key role in two aspects of growth cone navigation. One line of evidence implies a local synthesis of proteins that mediate growth cone collapse and turning in response to guidance cues; another indicates that growth cones possess the machinery ...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/s0092-8674(02)00934-0
更新日期:2002-09-06 00:00:00
abstract::Antibodies to DNA and chromatin drive autoimmunity in systemic lupus erythematosus (SLE). Null mutations and hypomorphic variants of the secreted deoxyribonuclease DNASE1L3 are linked to familial and sporadic SLE, respectively. We report that DNASE1L3-deficient mice rapidly develop autoantibodies to DNA and chromatin,...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.05.034
更新日期:2016-06-30 00:00:00
abstract::Many organs are composed of epithelial tubes that transport vital fluids. Such tubular organs develop in many different ways and generate tubes of widely varying sizes and structures, but always with the apical epithelial surface lining the lumen. We describe recent progress in several diverse cell culture and genetic...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/s0092-8674(02)01283-7
更新日期:2003-01-10 00:00:00
abstract::The synthesis of histones and DNA was examined in BHK cells arrested in G1 by isoleucine starvation and in cells progressing into the S phase upon isoleucine refeeding. Approximately 2-3% of the cells were not arrested in G1 and synthesized DNA. The rate of synthesis of DNA and nucleosomal histones observed in cells s...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(78)90092-2
更新日期:1978-09-01 00:00:00
abstract::E. coli sigma 54 protein confers on promoters containing its recognition sequence the ability to be activated from distant DNA sites. Its functional domains include two leucine zipper motifs, an acidic region, and a glutamine-rich domain. Several domains were disrupted and the assembly of mutant transcription complexe...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90269-k
更新日期:1990-09-07 00:00:00
abstract::The rapid cell proliferation characteristic of early animal embryos is accomplished with an abbreviated cell cycle and no DNA replication checkpoint. Blythe and Wieschaus provide evidence that nascent zygotic transcription precedes—and may trigger—this checkpoint at the midblastula transition. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2015.02.051
更新日期:2015-03-12 00:00:00
abstract::Genetic information flows from DNA to macromolecular structures-the dominant force in the molecular organization of life. However, recent work suggests that metabolite availability to the hexosamine and Golgi N-glycosylation pathways exerts control over the assembly of macromolecular complexes on the cell surface and,...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2009.12.008
更新日期:2009-12-24 00:00:00
abstract::Previous experiments have shown that mRNA translation in frog oocytes can be inhibited by the injection of a complementary antisense RNA. Here we explore the use of antisense RNAs to study the functions of localized maternal mRNAs during postfertilization development. While developmental abnormalities were observed in...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90238-8
更新日期:1987-02-27 00:00:00
abstract::Transcriptional regulation by the glucocorticoid receptor (GR) is mediated by hormone binding, receptor dimerization, and coactivator recruitment. Here, we report the crystal structure of the human GR ligand binding domain (LBD) bound to dexamethasone and a coactivator motif derived from the transcriptional intermedia...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(02)00817-6
更新日期:2002-07-12 00:00:00
abstract::In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic cells is unknown. Here, we show that NPCs, unlike other nuclear structures, do not turn over in differentiated cells. While a subset of NPC compone...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2008.11.037
更新日期:2009-01-23 00:00:00
abstract::The mRNAs from two yeast mitochondrial genes cob-box (cytochrome b) and oxi-3 (cytochrome oxidase 40,000 dalton subunit) are processed from large (7-10 kb) precursors. Certain mutations in each gene block the maturation of the RNAs from both genes at a variety of specific steps. The pleiotropic cytochrome b mutants se...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(79)90233-2
更新日期:1979-12-01 00:00:00
abstract::Models of transcription are often built around a picture of RNA polymerase and transcription factors (TFs) acting on a single copy of a promoter. However, most TFs are shared between multiple genes with varying binding affinities. Beyond that, genes often exist at high copy number-in multiple identical copies on the c...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.02.022
更新日期:2014-03-13 00:00:00
abstract::We have generated mice lacking H2-M complexes, critical facilitators of peptide loading onto major histo-compatibility complex class II molecules. Ab molecules in these mice matured into stable complexes and were efficiently expressed at the cell surface. Most carried a single peptide derived from the class II-associa...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81029-6
更新日期:1996-02-23 00:00:00
abstract::Polycomb group (PcG) proteins form large multimeric complexes (PcG bodies) which are involved in the stable repression of gene expression. The human PcG protein, Pc2, has been shown to recruit the transcriptional corepressor, CtBP, to PcG bodies. We show that CtBP is sumoylated at a single lysine. In vitro, CtBP sumoy...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(03)00159-4
更新日期:2003-04-04 00:00:00
abstract::Individual olfactory sensory neurons express only a single odorant receptor from a large family of genes, and this singularity is an essential feature in models of olfactory perception. We have devised a genetic strategy to examine the stability of receptor choice. We observe that immature olfactory sensory neurons th...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2004.05.015
更新日期:2004-06-11 00:00:00
abstract::Ca(2+) binding to synaptotagmin 1 triggers fast exocytosis of synaptic vesicles that have been primed for release by SNARE-complex assembly. Besides synaptotagmin 1, fast Ca(2+)-triggered exocytosis requires complexins. Synaptotagmin 1 and complexins both bind to assembled SNARE complexes, but it is unclear how their ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.08.030
更新日期:2006-09-22 00:00:00