Abstract:
:Many organs are composed of epithelial tubes that transport vital fluids. Such tubular organs develop in many different ways and generate tubes of widely varying sizes and structures, but always with the apical epithelial surface lining the lumen. We describe recent progress in several diverse cell culture and genetic models of tube morphogenesis, which suggest apical membrane biogenesis, vesicle fusion, and secretion play central roles in tube formation and growth. We propose a unifying mechanism of tube morphogenesis that has been modified to create tube diversity and describe how defects in the tube size-sensing step can lead to polycystic kidney disease.
journal_name
Celljournal_title
Cellauthors
Lubarsky B,Krasnow MAdoi
10.1016/s0092-8674(02)01283-7subject
Has Abstractpub_date
2003-01-10 00:00:00pages
19-28issue
1eissn
0092-8674issn
1097-4172pii
S0092867402012837journal_volume
112pub_type
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