Abstract：
:Maintaining the pluripotency of mouse ES cells requires both LIF (leukemia inhibitory factor) and unknown factors in serum. The paper from Ying et al. in this issue of Cell shows that BMP (bone morphogenetic protein) can replace serum in this capacity, defining molecular requirements for ES cell self-renewal.
journal_name
Celljournal_title
Cellauthors
Temple Sdoi
10.1016/s0092-8674(03)00853-5subject
Has Abstractpub_date
2003-10-31 00:00:00pages
247-8issue
3eissn
0092-8674issn
1097-4172pii
S0092867403008535journal_volume
115pub_type
评论,杂志文章相关文献
CELL文献大全abstract：:Aging entails a progressive decline in protein homeostasis, which often leads to age-related diseases. The endoplasmic reticulum (ER) is the site of protein synthesis and maturation for secreted and membrane proteins. Correct folding of ER proteins requires covalent attachment of N-linked glycan oligosaccharides. Here...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.01.061
更新日期：2014-03-13 00:00:00
abstract：:Certain tRNAs in S. cerevisiae (tRNATyr and tRNAPhe) arise via precursor molecules which are mature at the 5' and 3' termini but contain intervening sequences adjacent to the anticodon (Knapp et al., 1978; O'Farrell et al., 1978). In addition to these molecules, precursors to several other tRNAs accumulate in a temper...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90349-0
更新日期：1979-09-01 00:00:00
abstract：:A key feature of plants (as opposed to animals) is their ability to establish new organs not only during embryogenesis, but also throughout their development. A master regulator of organ initiation in plants is the phytohormone auxin. Auxin acts locally as a morphogen and is directionally transported from cell to cell...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.08.040
更新日期：2007-09-21 00:00:00
abstract：:We have isolated cDNA clones generated from the mRNA encoding the opsin apoprotein of bovine rhodopsin and used these cDNAs to isolate genomic DNA clones containing the complete opsin gene. Nucleotide sequence analysis of the cloned DNAs has yielded a complete amino acid sequence for bovine rhodopsin and provided an i...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90537-8
更新日期：1983-10-01 00:00:00
abstract：:Transcription hinders replication fork progression and stability. The ATR checkpoint and specialized DNA helicases assist DNA synthesis across transcription units to protect genome integrity. Combining genomic and genetic approaches together with the analysis of replication intermediates, we searched for factors coord...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.09.041
更新日期：2012-11-09 00:00:00
abstract：:The temperature-sensitive mutant of yeast, rna2-, when incubated at the nonpermissive temperature, has a qualitatively distinct distribution of mRNA sequences as compared to wild-type. Quantitative comparison with the wild-type distribution indicates that after 1 hr at the nonpermissive temperature, the concentration ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(77)90033-2
更新日期：1977-03-01 00:00:00
abstract：:Histone methylation regulates chromatin structure and transcription. The recently identified histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to demethylation of only mono- and di- but not trimethylated histone H3 lysine 4 (H3K4me3). We show that the X-linked mental retardation (XLMR) ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.02.017
更新日期：2007-03-23 00:00:00
abstract：:Expression of human immunodeficiency virus type 1 structural proteins requires both the viral Rev trans-activator and its cis-acting RNA target sequence, the Rev response element (RRE). The RRE has been mapped to a conserved region of the HIV-1 env gene and is predicted to form a complex, highly stable RNA stem-loop s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90670-a
更新日期：1990-02-23 00:00:00
abstract：:The transcription factor HIF-1 mediates adaptive responses to hypoxia, and its activity is negatively regulated by O2-dependent binding of the von Hippel-Lindau (VHL) protein. In this issue, Boutin et al. (2008) use conditional knockout mice to demonstrate that sensing of O2 by keratinocytes in the epidermis leads to ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2008.04.004
更新日期：2008-04-18 00:00:00
abstract：:It is increasingly appreciated that oncogenic transformation alters cellular metabolism to facilitate cell proliferation, but less is known about the metabolic changes that promote cancer cell aggressiveness. Here, we analyzed metabolic gene expression in cancer cell lines and found that a set of high-grade carcinoma ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.07.032
更新日期：2014-08-28 00:00:00
abstract：:Major depressive disorder (MDD) patients display a common but often variable set of symptoms making successful, sustained treatment difficult to achieve. Separate depressive symptoms may be encoded by differential changes in distinct circuits in the brain, yet how discrete circuits underlie behavioral subsets of depre...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.06.015
更新日期：2017-07-13 00:00:00
abstract：:The rapid cell proliferation characteristic of early animal embryos is accomplished with an abbreviated cell cycle and no DNA replication checkpoint. Blythe and Wieschaus provide evidence that nascent zygotic transcription precedes—and may trigger—this checkpoint at the midblastula transition. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2015.02.051
更新日期：2015-03-12 00:00:00
abstract：:We have isolated the bovine and human genes for Müllerian inhibiting substance (MIS), a testicular glycoprotein that causes regression of the Müllerian duct during development of the male embryo. The mRNA sequence of bovine MIS, determined from an analysis of cDNA and genomic clones, codes for a protein of 575 amino a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90783-x
更新日期：1986-06-06 00:00:00
abstract：:During the early stage of Ad2 infection of human cells, RNA is transcribed from five separate transcription units. Early region II encodes the mRNA for a 72K single-stranded DNA binding protein (DBP) which functions in DNA replication. This report describes the structure of the first leader of the DBP mRNA and the fla...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90073-4
更新日期：1979-10-01 00:00:00
abstract：:We wished to learn whether the genomes of strains of EMB isolated from patients with infectious mononucleosis are consistently distinguishable from those of strains from Burkitt's lymphoma. The genome of a new transforming strains (FF41) of EBV isolated from saliva of a patient with uncomplicated infectious mononucleo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90345-7
更新日期：1981-05-01 00:00:00
abstract：:The X-ray crystal structures of an anti-p24 (HIV-1) monoclonal antibody Fab fragment alone and in complexes with the epitope peptide GATPQDLNTnL (n = norleucine), an epitope-homologous peptide GATPEDLNQKLAGN, as well as two unrelated peptides GLYEWGGARITNTD and efslkGpllqwrsG (D-peptide), are presented to a maximum re...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80469-9
更新日期：1997-12-12 00:00:00
abstract：:The Rho family of GTPases control diverse biological processes, including cell morphology and mitogenesis. We have identified WASP, the protein that is defective in Wiskott-Aldrich syndrome (WAS), as a novel effector for CDC42Hs, but not for the other Rho family members, Rac and Rho. This interaction is dependent on t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81050-8
更新日期：1996-03-08 00:00:00
abstract：:Primary cell cultures of African Green monkey kidney (AGMK) contain polarized epithelial cells in which influenza virus matures predominantly at the apical surfaces above tight junctions. Influenza virus glycoproteins were found to be localized at the same membrane domain from which the virus budded. When polarized pr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90425-7
更新日期：1983-06-01 00:00:00
abstract：:Certain mutant alleles at the low density lipoprotein (LDL) receptor locus produce receptors that bind LDL normally, but fail to cluster in coated pits and therefore cannot transport LDL into cells. We prepared genomic DNA libraries from cells of two individuals with this phenotype (internalization-defective familial ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(85)80054-4
更新日期：1985-07-01 00:00:00
abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of request of the editors. Cell is retracting this paper reporting structures of a poxvirus protein, VCP, that inhi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00214-8
更新日期：2001-01-26 00:00:00
abstract：:Proteotypes, like genotypes, have been found to vary between individuals in several studies, but consistent molecular functional traits across studies remain to be quantified. In a meta-analysis of 11 proteomics datasets from humans and mice, we use co-variation of proteins in known functional modules across datasets ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.03.015
更新日期：2019-05-16 00:00:00
abstract：:The p53 tumor suppressor gene is commonly altered in human tumors, predominantly through missense mutations that result in accumulation of mutant p53 protein. These mutations may confer dominant-negative or gain-of-function properties to p53. To ascertain the physiological effects of p53 point mutation, the structural...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.11.004
更新日期：2004-12-17 00:00:00
abstract：:Cancer cell of origin is difficult to identify by analyzing cells within terminal stage tumors, whose identity could be concealed by the acquired plasticity. Thus, an ideal approach to identify the cell of origin is to analyze proliferative abnormalities in distinct lineages prior to malignancy. Here, we use mosaic an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.06.014
更新日期：2011-07-22 00:00:00
abstract：:The mechanisms by which immune checkpoint blockade modulates tumor evolution during therapy are unclear. We assessed genomic changes in tumors from 68 patients with advanced melanoma, who progressed on ipilimumab or were ipilimumab-naive, before and after nivolumab initiation (CA209-038 study). Tumors were analyzed by...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.09.028
更新日期：2017-11-02 00:00:00
abstract：:We have cloned a Dictyostelium phosphotyrosine phosphatase (PTP1) with a catalytic domain showing approximately 38%-50% amino acid identity to those of other PTPs. PTP1 contains an approximately 99 amino acid insert and bacterially produced PTP1 possesses PTP activity. PTP1 is expressed at a very low level in vegetati...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90597-6
更新日期：1992-11-13 00:00:00
abstract：:Ubiquitin chains serve as a recognition motif for the proteasome, a multisubunit protease, which degrades its substrates into polypeptides while releasing ubiquitin for reuse. Yeast proteasomes contain two deubiquitinating enzymes, Ubp6 and Rpn11. Rpn11 promotes protein breakdown through its degradation-coupled activi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.07.038
更新日期：2006-10-06 00:00:00
abstract：:Autophagy (literally self-eating) has diverse cytoprotective functions but also is linked to programmed cell death (PCD). In this issue, Qu et al. (2007) analyze the role of autophagy in PCD during development. Unexpectedly they find that autophagy induces apoptotic cells to present a signal to ensure their clearance,...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2007.02.023
更新日期：2007-03-09 00:00:00
abstract：:Activins are involved in the regulation of multiple biological events, ranging from early development to pituitary function. To characterize the cellular mechanisms involved in these processes, cDNAs coding for an activin receptor were cloned from AtT20 mouse corticotropic cells by screening COS cell transfectants for...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90549-e
更新日期：1991-06-14 00:00:00
abstract：:Molecular chaperones assist protein folding by facilitating their "forward" folding and preventing aggregation. However, once aggregates have formed, these chaperones cannot facilitate protein disaggregation. Bacterial ClpB and its eukaryotic homolog Hsp104 are essential proteins of the heat-shock response, which have...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00807-9
更新日期：2003-10-17 00:00:00
abstract：:K-Ras is targeted to the plasma membrane by a C-terminal membrane anchor that comprises a farnesyl-cysteine-methyl-ester and a polybasic domain. We used quantitative spatial imaging and atomistic molecular dynamics simulations to examine molecular details of K-Ras plasma membrane binding. We found that the K-Ras ancho...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.11.059
更新日期：2017-01-12 00:00:00
