Abstract：
:Primary cell cultures of African Green monkey kidney (AGMK) contain polarized epithelial cells in which influenza virus matures predominantly at the apical surfaces above tight junctions. Influenza virus glycoproteins were found to be localized at the same membrane domain from which the virus budded. When polarized primary AGMK cells were infected with recombinant SV40 viruses containing DNA coding for either an influenza virus H1 or H2 subtype hemagglutinin (HA), the HA proteins were preferentially expressed at the apical surface in a manner identical to that observed in influenza virus-infected cells. Thus, cellular mechanisms for sorting membrane glycoproteins recognize some structural feature of the HA glycoprotein itself, and other viral proteins are not necessary for this process.
journal_name
Celljournal_title
Cellauthors
Roth MG,Compans RW,Giusti L,Davis AR,Nayak DP,Gething MJ,Sambrook Jdoi
10.1016/0092-8674(83)90425-7subject
Has Abstractpub_date
1983-06-01 00:00:00pages
435-43issue
2eissn
0092-8674issn
1097-4172pii
0092-8674(83)90425-7journal_volume
33pub_type
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