FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate.


:During development, distinct classes of neurons are specified in precise locations along the dorso-ventral and anterior-posterior axes of the neural tube. We provide evidence that intersections of Shh, which is expressed along the ventral neural tube, and FGF8, which is locally produced at the mid/hindbrain boundary and in the rostral forebrain, create induction sites for dopaminergic neurons in the midbrain and forebrain. The same intersection, when preceded by a third signal, FGF4, which is expressed in the primitive streak, defines an inductive center for hindbrain 5-HT neurons. These findings illustrate that cell patterning in the neural plate is a multistep process in which early inducers, which initially divide the neural plate into crude compartments, are replaced by multiple local organizing centers, which specify distinct neuronal cell types within these compartments.






Ye W,Shimamura K,Rubenstein JL,Hynes MA,Rosenthal A




Has Abstract


1998-05-29 00:00:00
















  • Transcription initiation at its most basic level.

    abstract::The structure of the initiator binding protein from the primitive eukaryote Trichomonas vaginalis reveals how a single protein can orchestrate promoter recognition, RNA polymerase II recruitment, and start site selection, and provides an evolutionary link with transcription initiation in higher eukaryotes. ...


    pub_type: 评论,杂志文章


    authors: Marmorstein R

    更新日期:2003-11-14 00:00:00

  • Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release.

    abstract::We have identified mutations in Drosophila endophilin to study its function in vivo. Endophilin is required presynaptically at the neuromuscular junction, and absence of Endophilin dramatically impairs endocytosis in vivo. Mutant larvae that lack Endophilin fail to take up FM1-43 dye in synaptic boutons, indicating an...


    pub_type: 杂志文章


    authors: Verstreken P,Kjaerulff O,Lloyd TE,Atkinson R,Zhou Y,Meinertzhagen IA,Bellen HJ

    更新日期:2002-04-05 00:00:00

  • Genomic Analysis in the Age of Human Genome Sequencing.

    abstract::Affordable genome sequencing technologies promise to revolutionize the field of human genetics by enabling comprehensive studies that interrogate all classes of genome variation, genome-wide, across the entire allele frequency spectrum. Ongoing projects worldwide are sequencing many thousands-and soon millions-of huma...


    pub_type: 杂志文章,评审


    authors: Lappalainen T,Scott AJ,Brandt M,Hall IM

    更新日期:2019-03-21 00:00:00

  • Entry of RNA polymerase at the lac promoter.

    abstract::The pathway of RNA polymerase entry at the lac promoter was studied by investigating the relationship between the promoter and a weak, overlapping polymerase interaction site (P2). If polymerase is made to enter the DNA by binding in vitro at this P2 site, cyclic AMP receptor protein (CRP) actively removes polymerase ...


    pub_type: 杂志文章


    authors: Meiklejohn AL,Gralla JD

    更新日期:1985-12-01 00:00:00

  • GroEL1: a dedicated chaperone involved in mycolic acid biosynthesis during biofilm formation in mycobacteria.

    abstract::Mycobacteria are unusual in encoding two GroEL paralogs, GroEL1 and GroEL2. GroEL2 is essential--presumably providing the housekeeping chaperone functions--while groEL1 is nonessential, contains the attB site for phage Bxb1 integration, and encodes a putative chaperone with unusual structural features. Inactivation of...


    pub_type: 杂志文章


    authors: Ojha A,Anand M,Bhatt A,Kremer L,Jacobs WR Jr,Hatfull GF

    更新日期:2005-12-02 00:00:00

  • N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.

    abstract::N(6)-methyladenosine (m(6)A) is the most abundant internal modification in mammalian mRNA. This modification is reversible and non-stoichiometric and adds another layer to the dynamic control of mRNA metabolism. The stability of m(6)A-modified mRNA is regulated by an m(6)A reader protein, human YTHDF2, which recognize...


    pub_type: 杂志文章


    authors: Wang X,Zhao BS,Roundtree IA,Lu Z,Han D,Ma H,Weng X,Chen K,Shi H,He C

    更新日期:2015-06-04 00:00:00

  • Three-dimensional structure of hepatitis B virus core particles determined by electron cryomicroscopy.

    abstract::Human hepatitis B virus core protein expressed in E. coli assembles into two sizes of particle. We have determined their three-dimensional structures by electron cryomicroscopy and image processing. The large and small particles correspond to triangulation number T = 4 and T = 3 dimer clustered packings, containing 24...


    pub_type: 杂志文章


    authors: Crowther RA,Kiselev NA,Böttcher B,Berriman JA,Borisova GP,Ose V,Pumpens P

    更新日期:1994-06-17 00:00:00

  • Progression to steroid insensitivity can occur irrespective of the presence of functional steroid receptors.

    abstract::A major problem in treatment of cancers arising in steroid-sensitive cells is their inevitable progression to a steroid-insensitive state; current therapies are based on the assumption that hormone insensitivity is associated with loss of receptor. We demonstrate for the first time that breast tumor cells can progress...


    pub_type: 杂志文章


    authors: Darbre PD,King RJ

    更新日期:1987-11-20 00:00:00

  • Fertile waters for aging research.

    abstract::The quest to slow aging has come far, and what used to be the domain of science fiction writers and snake oil salesmen may soon become science fact. Innovative new approaches, such as the use of the very short-lived African killifish (Harel et al.), are bridging the translational gap and bring the promise of healthy l...


    pub_type: 评论,杂志文章


    authors: Wang AM,Promislow DEL,Kaeberlein M

    更新日期:2015-02-26 00:00:00

  • The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

    abstract::Histone methylation regulates chromatin structure and transcription. The recently identified histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to demethylation of only mono- and di- but not trimethylated histone H3 lysine 4 (H3K4me3). We show that the X-linked mental retardation (XLMR) ...


    pub_type: 杂志文章


    authors: Iwase S,Lan F,Bayliss P,de la Torre-Ubieta L,Huarte M,Qi HH,Whetstine JR,Bonni A,Roberts TM,Shi Y

    更新日期:2007-03-23 00:00:00

  • Glia Get Neurons in Shape.

    abstract::Glial cells are essential components of the nervous system. In this issue, Singhvi et al. uncover cellular and molecular mechanisms through which C. elegans glia shape sensory neuron terminals and thus control animal thermosensing behaviors. ...


    pub_type: 评论,杂志文章


    authors: Sun LO,Barres BA

    更新日期:2016-05-05 00:00:00

  • Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7.

    abstract::Initiation of tumorigenesis in mouse skin can be accomplished by mutagenesis of the H-ras gene by treatment with chemical carcinogens. A mouse model system has been developed to study the additional genetic events that take place during tumor progression. Skin carcinomas were induced in F1 hybrid mice exhibiting restr...


    pub_type: 杂志文章


    authors: Bremner R,Balmain A

    更新日期:1990-05-04 00:00:00

  • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

    abstract::Bcl-2 protein is able to repress a number of apoptotic death programs. To investigate the mechanism of Bcl-2's effect, we examined whether Bcl-2 interacted with other proteins. We identified an associated 21 kd protein partner, Bax, that has extensive amino acid homology with Bcl-2, focused within highly conserved dom...


    pub_type: 杂志文章


    authors: Oltvai ZN,Milliman CL,Korsmeyer SJ

    更新日期:1993-08-27 00:00:00

  • A CK2-dependent mechanism for degradation of the PML tumor suppressor.

    abstract::The PML tumor suppressor controls key pathways for growth suppression, induction of apoptosis, and cellular senescence. PML loss occurs frequently in human tumors through unknown posttranslational mechanisms. Casein kinase 2 (CK2) is oncogenic and frequently upregulated in human tumors. Here we show that CK2 regulates...


    pub_type: 杂志文章


    authors: Scaglioni PP,Yung TM,Cai LF,Erdjument-Bromage H,Kaufman AJ,Singh B,Teruya-Feldstein J,Tempst P,Pandolfi PP

    更新日期:2006-07-28 00:00:00

  • The path of messenger RNA through the ribosome.

    abstract::Using X-ray crystallography, we have directly observed the path of mRNA in the 70S ribosome in Fourier difference maps at 7 A resolution. About 30 nucleotides of the mRNA are wrapped in a groove that encircles the neck of the 30S subunit. The Shine-Dalgarno helix is bound in a large cleft between the head and the back...


    pub_type: 杂志文章


    authors: Yusupova GZ,Yusupov MM,Cate JH,Noller HF

    更新日期:2001-07-27 00:00:00

  • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene.

    abstract::Mice deficient for interleukin-2 develop normally during the first 3-4 weeks of age. However, later on they become severely compromised, and about 50% of the animals die between 4 and 9 weeks after birth. Of the remaining mice, 100% develop an inflammatory bowel disease with striking clinical and histological similari...


    pub_type: 杂志文章


    authors: Sadlack B,Merz H,Schorle H,Schimpl A,Feller AC,Horak I

    更新日期:1993-10-22 00:00:00

  • The BELL1 gene encodes a homeodomain protein involved in pattern formation in the Arabidopsis ovule primordium.

    abstract::Ovule development in Arabidopsis involves the formation of three morphologically defined proximal-distal pattern elements. Integuments arise from the central pattern element. Analysis of Bell 1 (Bel 1) mutant ovules indicated that BEL1 was required for integument development. Cloning of the BEL1 locus reveals that it ...


    pub_type: 杂志文章


    authors: Reiser L,Modrusan Z,Margossian L,Samach A,Ohad N,Haughn GW,Fischer RL

    更新日期:1995-12-01 00:00:00

  • Small RNA-mediated activation of sugar phosphatase mRNA regulates glucose homeostasis.

    abstract::Glucose homeostasis is strictly controlled in all domains of life. Bacteria that are unable to balance intracellular sugar levels and deal with potentially toxic phosphosugars cease growth and risk being outcompeted. Here, we identify the conserved haloacid dehalogenase (HAD)-like enzyme YigL as the previously hypothe...


    pub_type: 杂志文章


    authors: Papenfort K,Sun Y,Miyakoshi M,Vanderpool CK,Vogel J

    更新日期:2013-04-11 00:00:00

  • Periodic transcription of yeast histone genes.

    abstract::Periodic transcription of yeast histone genes has been demonstrated by DNA excess filter hybridization of in vivo pulse-labeled RNA isolated from synchronous cell cultures. Using strains carrying cell division cycle (cdc) mutations, we show that both activation and termination of transcription are determined by tempor...


    pub_type: 杂志文章


    authors: Hereford L,Bromley S,Osley MA

    更新日期:1982-08-01 00:00:00

  • Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila.

    abstract::Information processing relies on precise patterns of synapses between neurons. The cellular recognition mechanisms regulating this specificity are poorly understood. In the medulla of the Drosophila visual system, different neurons form synaptic connections in different layers. Here, we sought to identify candidate ce...


    pub_type: 杂志文章


    authors: Tan L,Zhang KX,Pecot MY,Nagarkar-Jaiswal S,Lee PT,Takemura SY,McEwen JM,Nern A,Xu S,Tadros W,Chen Z,Zinn K,Bellen HJ,Morey M,Zipursky SL

    更新日期:2015-12-17 00:00:00

  • The Identity of Human Tissue-Emigrant CD8+ T Cells.

    abstract::Lymphocyte migration is essential for adaptive immune surveillance. However, our current understanding of this process is rudimentary, because most human studies have been restricted to immunological analyses of blood and various tissues. To address this knowledge gap, we used an integrated approach to characterize ti...


    pub_type: 杂志文章


    authors: Buggert M,Vella LA,Nguyen S,Wu VH,Chen Z,Sekine T,Perez-Potti A,Maldini CR,Manne S,Darko S,Ransier A,Kuri-Cervantes L,Japp AS,Brody IB,Ivarsson MA,Gorin JB,Rivera-Ballesteros O,Hertwig L,Antel JP,Johnson ME,Okoye

    更新日期:2020-12-23 00:00:00

  • Localization of specificity determining sites in cadherin cell adhesion molecules.

    abstract::Cadherins are a group of homophilic intercellular adhesion molecules; each member of this family exhibits binding specificity. Here, we attempted to map the sites for the specificities of these molecules by analyzing adhesives selectivities of the cells that express chimeric and point-mutated E- and P-cadherin. The re...


    pub_type: 杂志文章


    authors: Nose A,Tsuji K,Takeichi M

    更新日期:1990-04-06 00:00:00

  • Specific sequences and a hairpin structure in the template strand are required for N4 virion RNA polymerase promoter recognition.

    abstract::Coliphage N4 virion-encapsidated, DNA-dependent RNA polymerase (vRNAP) is inactive on double-stranded N4 DNA; however, denatured promoter-containing templates are accurately transcribed. We report that all determinants of vRNAP promoter recognition exist in the template strand, indicating that this enzyme is a site-sp...


    pub_type: 杂志文章


    authors: Glucksmann MA,Markiewicz P,Malone C,Rothman-Denes LB

    更新日期:1992-08-07 00:00:00

  • Lateral and axial signals involved in avian somite patterning: a role for BMP4.

    abstract::In vertebrates, muscles of the limbs and body wall derive from the lateral compartment of the embryonic somites, and axial muscles derive from the medial compartment. Whereas the mechanisms that direct patterning of somites along the dorsoventral axis are beginning to be understood, little is known about the tissue in...


    pub_type: 杂志文章


    authors: Pourquié O,Fan CM,Coltey M,Hirsinger E,Watanabe Y,Bréant C,Francis-West P,Brickell P,Tessier-Lavigne M,Le Douarin NM

    更新日期:1996-02-09 00:00:00

  • From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II.

    abstract::RNA polymerase II (RNAPII) lies at the core of dynamic control of gene expression. Using 53 RNAPII point mutants, we generated a point mutant epistatic miniarray profile (pE-MAP) comprising ∼60,000 quantitative genetic interactions in Saccharomyces cerevisiae. This analysis enabled functional assignment of RNAPII subd...


    pub_type: 杂志文章


    authors: Braberg H,Jin H,Moehle EA,Chan YA,Wang S,Shales M,Benschop JJ,Morris JH,Qiu C,Hu F,Tang LK,Fraser JS,Holstege FC,Hieter P,Guthrie C,Kaplan CD,Krogan NJ

    更新日期:2013-08-15 00:00:00

  • Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses.

    abstract::Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells and identified three antibody classes, each capable of neutralizing di...


    pub_type: 杂志文章


    authors: Joyce MG,Wheatley AK,Thomas PV,Chuang GY,Soto C,Bailer RT,Druz A,Georgiev IS,Gillespie RA,Kanekiyo M,Kong WP,Leung K,Narpala SN,Prabhakaran MS,Yang ES,Zhang B,Zhang Y,Asokan M,Boyington JC,Bylund T,Darko S,Lees

    更新日期:2016-07-28 00:00:00

  • The transcription factor titration effect dictates level of gene expression.

    abstract::Models of transcription are often built around a picture of RNA polymerase and transcription factors (TFs) acting on a single copy of a promoter. However, most TFs are shared between multiple genes with varying binding affinities. Beyond that, genes often exist at high copy number-in multiple identical copies on the c...


    pub_type: 杂志文章


    authors: Brewster RC,Weinert FM,Garcia HG,Song D,Rydenfelt M,Phillips R

    更新日期:2014-03-13 00:00:00

  • Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation.

    abstract::A key step in the regulation of transcription involves interactions between promoter-selective factors and various components of the transcriptional apparatus. Here we report the requirements for transcriptional activation directed by NTF-1, a developmentally regulated transcription factor in Drosophila. Reconstituted...


    pub_type: 杂志文章


    authors: Dynlacht BD,Hoey T,Tjian R

    更新日期:1991-08-09 00:00:00

  • Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis.

    abstract::Throughout a 24-h period, the small intestine (SI) is exposed to diurnally varying food- and microbiome-derived antigenic burdens but maintains a strict immune homeostasis, which when perturbed in genetically susceptible individuals, may lead to Crohn disease. Herein, we demonstrate that dietary content and rhythmicit...


    pub_type: 杂志文章


    authors: Tuganbaev T,Mor U,Bashiardes S,Liwinski T,Nobs SP,Leshem A,Dori-Bachash M,Thaiss CA,Pinker EY,Ratiner K,Adlung L,Federici S,Kleimeyer C,Moresi C,Yamada T,Cohen Y,Zhang X,Massalha H,Massasa E,Kuperman Y,Koni PA,H

    更新日期:2020-09-17 00:00:00

  • A ribonucleolytic rat torpedoes RNA polymerase II.

    abstract::Three recent papers reveal a fascinating link between pol II termination and ribonucleolytic decay of the nascent transcript by a 5'-3' exonuclease (yeast Rat1 and human Xrn2). The exonuclease travels with pol II and gains access to the nascent RNA after endonucleolytic cleavage at the poly(A) site or at a second cotr...


    pub_type: 杂志文章


    authors: Luo W,Bentley D

    更新日期:2004-12-29 00:00:00