Abstract:
:The broad expression of the insulin receptor suggests that the spectrum of insulin function has not been fully described. A cell type expressing this receptor is the osteoblast, a bone-specific cell favoring glucose metabolism through a hormone, osteocalcin, that becomes active once uncarboxylated. We show here that insulin signaling in osteoblasts is necessary for whole-body glucose homeostasis because it increases osteocalcin activity. To achieve this function insulin signaling in osteoblasts takes advantage of the regulation of osteoclastic bone resorption exerted by osteoblasts. Indeed, since bone resorption occurs at a pH acidic enough to decarboxylate proteins, osteoclasts determine the carboxylation status and function of osteocalcin. Accordingly, increasing or decreasing insulin signaling in osteoblasts promotes or hampers glucose metabolism in a bone resorption-dependent manner in mice and humans. Hence, in a feed-forward loop, insulin signals in osteoblasts activate a hormone, osteocalcin, that promotes glucose metabolism.
journal_name
Celljournal_title
Cellauthors
Ferron M,Wei J,Yoshizawa T,Del Fattore A,DePinho RA,Teti A,Ducy P,Karsenty Gdoi
10.1016/j.cell.2010.06.003subject
Has Abstractpub_date
2010-07-23 00:00:00pages
296-308issue
2eissn
0092-8674issn
1097-4172pii
S0092-8674(10)00621-5journal_volume
142pub_type
杂志文章相关文献
CELL文献大全abstract::Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These states are associated w...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.12.012
更新日期:2018-01-11 00:00:00
abstract::The brlA gene of A. nidulans mediates the developmental switch from the indeterminate, apical growth pattern of vegetative cells to the budding growth pattern of conidiophores. brlA encodes a 432 amino acid polypeptide containing two directly repeated motifs resembling the Zn(II) coordination sites first recognized in...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(88)90198-5
更新日期:1988-07-29 00:00:00
abstract::Nuclear hormone receptors comprise a superfamily of ligand-modulated transcription factors that mediate the transcriptional activities of steroids, retinoids, and thyroid hormones. A growing number of related proteins have been identified that possess the structural features of hormone receptors, but that lack known l...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90530-8
更新日期:1995-06-02 00:00:00
abstract::Rho and rac, two members of the ras-related superfamily of small GTPases, regulate the polymerization of actin to produce stress fibers and lamellipodia, respectively. We report here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell peripher...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90370-4
更新日期:1995-04-07 00:00:00
abstract::Dysfunctional mitochondria accumulate in many human diseases. Accordingly, mitophagy, which removes these mitochondria through lysosomal degradation, is attracting broad attention. Due to uncertainties in the operational principles of conventional mitophagy probes, however, the specificity and quantitativeness of thei...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.04.025
更新日期:2020-05-28 00:00:00
abstract::Multidrug resistance in human cells results from increased expression of the mdr1 (P-glycoprotein) gene. Although the same gene is activated in cells selected with different drugs, multidrug-resistant cell lines can be preferentially resistant to their selecting agent. The mdr1 cDNA sequence from vinblastine-selected ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(88)90568-5
更新日期:1988-05-20 00:00:00
abstract::Inflammation is associated with many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this Review, we discuss inducers, sensors, transducers, and effectors of neuroinflammation that contribute to neuronal dysfunction and death. Al...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2010.02.016
更新日期:2010-03-19 00:00:00
abstract::Bacteria can respond to adverse environmental conditions by drastically reducing or even ceasing metabolic activity. They must then determine that conditions have improved before exiting dormancy, and one indication of such a change is the growth of other bacteria in the local environment. Growing bacteria release mur...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2008.08.039
更新日期:2008-10-31 00:00:00
abstract::Ethylene regulates many aspects of plant growth and development. In the presence of ethylene, the C terminus of EIN2 (EIN2C) translocates into the nucleus and activates transcription. Li et al. and Merchante et al. show that EIN2C also regulates translation through an interaction with the 3' UTRs of transcripts. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2015.10.032
更新日期:2015-10-22 00:00:00
abstract::We explored how the odor map in the Drosophila antennal lobe is represented in higher olfactory centers, the mushroom body and lateral horn. Systematic single-cell tracing of projection neurons (PNs) that send dendrites to specific glomeruli in the antennal lobe revealed their stereotypical axon branching patterns and...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(02)00700-6
更新日期:2002-04-19 00:00:00
abstract::When the human beta-globin gene is transfected into Hela cells, no beta-globin RNA is detected unless the gene is linked to a viral transcription enhancer. In this paper we show that trans-acting adenovirus and herpesvirus (pseudorabies) transcriptional regulatory proteins can circumvent this enhancer requirement for ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(83)90216-7
更新日期:1983-11-01 00:00:00
abstract::In nematodes, a fraction of mRNAs contains a common 22 nucleotide 5' terminal spliced leader (SL) sequence derived by trans splicing. Here, we show that a cell-free extract prepared from developing embryos of the parasitic nematode Ascaris lumbricoides catalyzes accurate and efficient SL addition to a synthetic pre-mR...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90689-c
更新日期:1990-06-29 00:00:00
abstract::Electrophoretic and autoradiographic analyses of the incorporation of 35S--methionine into newly synthesized proteins during myogenesis reveal that presumptive chicken myoblasts synthesize primarily one intermediate filament protein: vimentin. Desmin synthesis is initiated at the onset of fusion. Synthesis rates of bo...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(80)90408-0
更新日期:1980-01-01 00:00:00
abstract::Initiation of tumorigenesis in mouse skin can be accomplished by mutagenesis of the H-ras gene by treatment with chemical carcinogens. A mouse model system has been developed to study the additional genetic events that take place during tumor progression. Skin carcinomas were induced in F1 hybrid mice exhibiting restr...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90523-h
更新日期:1990-05-04 00:00:00
abstract::Chemotherapy results in a frequent yet poorly understood syndrome of long-term neurological deficits. Neural precursor cell dysfunction and white matter dysfunction are thought to contribute to this debilitating syndrome. Here, we demonstrate persistent depletion of oligodendrocyte lineage cells in humans who received...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.10.049
更新日期:2019-01-10 00:00:00
abstract::Histone DNA of Psammechinus miliaris was obtained in an enriched form by buoyant density gradient centrifugation and was cleaved into 6 kb repeat units (Birnstiel et al., 1975a) by the action of the specific endonucleases EcoRI and HindIII. Since it was suspected that the 6 kb unit harbored all five histone-coding seq...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(76)90214-2
更新日期:1976-08-01 00:00:00
abstract::Pure primary mesenchymal cells from definitive streak stage chick embryos have been prepared free of epiblast and hypoblast cells. These cells have the potential in culture to differentiate into erythroid cells, beating heart muscle tissue, chondrocytes and epithelial cells. Transformation in vitro of pure primary mes...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(79)90320-9
更新日期:1979-08-01 00:00:00
abstract::Elucidating the global and local rules that govern genome-wide, hierarchical chromatin architecture remains a critical challenge. Current high-throughput chromosome conformation capture (Hi-C) technologies have identified large-scale chromatin structural motifs, such as topologically associating domains and looping. H...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.12.014
更新日期:2019-01-24 00:00:00
abstract::Fluorescent proteins are commonly used to label cells across organisms, but the unmodified forms cannot control biological activities. Using GFP-binding proteins derived from Camelid antibodies, we co-opted GFP as a scaffold for inducing formation of biologically active complexes, developing a library of hybrid transc...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.07.021
更新日期:2013-08-15 00:00:00
abstract::Transcriptional regulation by the glucocorticoid receptor (GR) is mediated by hormone binding, receptor dimerization, and coactivator recruitment. Here, we report the crystal structure of the human GR ligand binding domain (LBD) bound to dexamethasone and a coactivator motif derived from the transcriptional intermedia...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(02)00817-6
更新日期:2002-07-12 00:00:00
abstract::Properties of human anticentromere autoantibodies were analyzed. In intact cells or isolated cell fractions, these sera stain the centromeres of mitotic chromosomes and discrete speckles (prekinetochores) in nuclei. Staining is also retained in matrix preparations from nuclei or chromosomes. Immunoprecipitation or imm...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(83)90236-2
更新日期:1983-11-01 00:00:00
abstract::The non-receptor protein tyrosine phosphatase (PTP) SHP2, encoded by PTPN11, plays an essential role in RAS-mitogen-activated protein kinase (MAPK) signaling during normal development. It has been perplexing as to why both enzymatically activating and inactivating mutations in PTPN11 result in human developmental diso...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.09.002
更新日期:2020-10-15 00:00:00
abstract::Many naturalistic behaviors are built from modular components that are expressed sequentially. Although striatal circuits have been implicated in action selection and implementation, the neural mechanisms that compose behavior in unrestrained animals are not well understood. Here, we record bulk and cellular neural ac...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.04.019
更新日期:2018-06-28 00:00:00
abstract::Intestinal peristalsis is a dynamic physiologic process influenced by dietary and microbial changes. It is tightly regulated by complex cellular interactions; however, our understanding of these controls is incomplete. A distinct population of macrophages is distributed in the intestinal muscularis externa. We demonst...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.04.050
更新日期:2014-07-17 00:00:00
abstract::Dentatorubral-pallidoluysian atrophy is a progressive neurodegenerative disease caused by the expansion of a polyglutamine repeats within the Atrophin-1 protein. The in vivo function of Atrophin-1 is unknown. We have characterized a Drosophila gene encoding an Atrophin family protein. Analysis of mutant phenotypes ind...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00630-4
更新日期:2002-01-11 00:00:00
abstract::An examination of Abelson murine leukemia virus (A-MuL V)-hematopoietic cell interaction in cultures of fetal tissues reveals that A-MuLV can stimulate the formation of two different types of colonies. One type of colony is white and composed of A-MuLV-transformed lymphoid cells that can develop into established cell ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90035-0
更新日期:1981-10-01 00:00:00
abstract::The transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homolog (pp60c-src) are demonstrated to be phosphorylated at serine 12 in vivo under certain conditions. We propose that protein kinase C is responsible for this modification based on the following evidence. First, the tumor promoters, ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(85)90281-8
更新日期:1985-10-01 00:00:00
abstract::Mutations in gurken and torpedo cause a ventralization in the follicle cell epithelium during Drosophila oogenesis and in the pattern of the embryo that develops in the resultant egg. Both genes lie midway in an epistatic series between fs(1)K10 and dorsal; the mutations block the dorsalization normally observed in K1...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90546-0
更新日期:1987-06-05 00:00:00
abstract::Activation of the transcription factor NF-kappaB by tumor necrosis factor (TNF) and interleukin-1 (IL-1) requires the NF-kappaB-inducing kinase (NIK). In a yeast two-hybrid screen for NIK-interacting proteins, we have identified a protein kinase previously known as CHUK. Overexpression of CHUK activates a NF-kappaB-de...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80344-x
更新日期:1997-07-25 00:00:00
abstract::Methylation of arginine residues within histone H3 has been linked to active transcription. This modification appears on the estrogen-regulated pS2 promoter when the CARM1 methyltransferase is recruited during transcriptional activation. Here we describe a process, deimination, that converts histone arginine to citrul...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2004.08.020
更新日期:2004-09-03 00:00:00