Abstract：
:Many naturalistic behaviors are built from modular components that are expressed sequentially. Although striatal circuits have been implicated in action selection and implementation, the neural mechanisms that compose behavior in unrestrained animals are not well understood. Here, we record bulk and cellular neural activity in the direct and indirect pathways of dorsolateral striatum (DLS) as mice spontaneously express action sequences. These experiments reveal that DLS neurons systematically encode information about the identity and ordering of sub-second 3D behavioral motifs; this encoding is facilitated by fast-timescale decorrelations between the direct and indirect pathways. Furthermore, lesioning the DLS prevents appropriate sequence assembly during exploratory or odor-evoked behaviors. By characterizing naturalistic behavior at neural timescales, these experiments identify a code for elemental 3D pose dynamics built from complementary pathway dynamics, support a role for DLS in constructing meaningful behavioral sequences, and suggest models for how actions are sculpted over time.
journal_name
Celljournal_title
Cellauthors
Markowitz JE,Gillis WF,Beron CC,Neufeld SQ,Robertson K,Bhagat ND,Peterson RE,Peterson E,Hyun M,Linderman SW,Sabatini BL,Datta SRdoi
10.1016/j.cell.2018.04.019subject
Has Abstractpub_date
2018-06-28 00:00:00pages
44-58.e17issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(18)30512-9journal_volume
174pub_type
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