Abstract：
:Fertilized clam embryos synthesize several new cell-cycle-related proteins. The cloned cDNA and derived amino acid sequences of one of these, cyclin A, are presented here. Immunoblots with an anti-cyclin A antibody reveal that cyclin A is undetectable in oocytes, appears within 15 min of fertilization, and is destroyed near the end of each meiosis and mitosis. We directly tested the ability of cyclin A to induce M phase by injecting SP6 cyclin A mRNA into Xenopus oocytes, which are arrested at the G2/M border of first meiosis. The injected mRNA was translated, with the result that the Xenopus oocytes entered meiosis. These findings indicate that the rise in cyclin A plays a direct and natural role in driving cells into M phase.
journal_name
Celljournal_title
Cellauthors
Swenson KI,Farrell KM,Ruderman JVdoi
10.1016/0092-8674(86)90801-9subject
Has Abstractpub_date
1986-12-26 00:00:00pages
861-70issue
6eissn
0092-8674issn
1097-4172pii
0092-8674(86)90801-9journal_volume
47pub_type
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