The Cellular and Molecular Basis for Planarian Regeneration.

abstract：:Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients ...

journal_title：Cell

authors： Leslie NR,den Hertog J

更新日期：2014-04-24 00:00:00

abstract：:Eukaryotic translation initiation requires coordinated assembly of a remarkable array of initiation factors onto the small ribosomal subunit to select an appropriate mRNA start codon. Studies from Erzberger et al. and Hussain et al. bring new insights into this mechanism by looking at early and late initiation interme...

journal_title：Cell

authors： Korostelev AA

更新日期：2014-10-23 00:00:00

abstract：:Nucleosomes help structure chromosomes by compacting DNA into fibers. To gain insight into how nucleosomes are arranged in vivo, we combined quantitative super-resolution nanoscopy with computer simulations to visualize and count nucleosomes along the chromatin fiber in single nuclei. Nucleosomes assembled in heteroge...

journal_title：Cell

authors： Ricci MA,Manzo C,García-Parajo MF,Lakadamyali M,Cosma MP

更新日期：2015-03-12 00:00:00

abstract：:Pulmonary neuroendocrine (NE) cells are neurosensory cells sparsely distributed throughout the bronchial epithelium, many in innervated clusters of 20-30 cells. Following lung injury, NE cells proliferate and generate other cell types to promote epithelial repair. Here, we show that only rare NE cells, typically 2-4 p...

journal_title：Cell

authors： Ouadah Y,Rojas ER,Riordan DP,Capostagno S,Kuo CS,Krasnow MA

更新日期：2019-10-03 00:00:00

abstract：:We chemically synthesized 20 peptides corresponding to 75% of the HA1 molecule of the influenza virus. Antibodies to the majority (18) of these peptides were capable of reacting with the hemagglutinin molecule. These 18 peptides are not confined to the known antigenic determinants of the hemagglutinin molecule, but ra...

journal_title：Cell

authors： Green N,Alexander H,Olson A,Alexander S,Shinnick TM,Sutcliffe JG,Lerner RA

更新日期：1982-03-01 00:00:00

abstract：:Sterol regulatory element binding proteins (SREBPs) are transcription factors attached to the endoplasmic reticulum. The NH2-segment, which activates transcription, is connected to membranes by a hairpin anchor formed by two transmembrane sequences and a short lumenal loop. Using H-Ras-SREBP-2 fusion proteins, we show...

journal_title：Cell

authors： Sakai J,Duncan EA,Rawson RB,Hua X,Brown MS,Goldstein JL

更新日期：1996-06-28 00:00:00

abstract：:A safe and controlled manipulation of endocytosis in vivo may have disruptive therapeutic potential. Here, we demonstrate that the anti-emetic/anti-psychotic prochlorperazine can be repurposed to reversibly inhibit the in vivo endocytosis of membrane proteins targeted by therapeutic monoclonal antibodies, as directly ...

journal_title：Cell

authors： Chew HY,De Lima PO,Gonzalez Cruz JL,Banushi B,Echejoh G,Hu L,Joseph SR,Lum B,Rae J,O'Donnell JS,Merida de Long L,Okano S,King B,Barry R,Moi D,Mazzieri R,Thomas R,Souza-Fonseca-Guimaraes F,Foote M,McCluskey A,Robin

更新日期：2020-03-05 00:00:00

abstract：:The structure of the initiator binding protein from the primitive eukaryote Trichomonas vaginalis reveals how a single protein can orchestrate promoter recognition, RNA polymerase II recruitment, and start site selection, and provides an evolutionary link with transcription initiation in higher eukaryotes. ...

journal_title：Cell

authors： Marmorstein R

更新日期：2003-11-14 00:00:00

abstract：:Oncogenic activation of RAS genes via point mutations occurs in 20%-30% of human cancers. The development of effective RAS inhibitors has been challenging, necessitating new approaches to inhibit this oncogenic protein. Functional studies have shown that the switch region of RAS interacts with a large number of effect...

journal_title：Cell

authors： Athuluri-Divakar SK,Vasquez-Del Carpio R,Dutta K,Baker SJ,Cosenza SC,Basu I,Gupta YK,Reddy MV,Ueno L,Hart JR,Vogt PK,Mulholland D,Guha C,Aggarwal AK,Reddy EP

更新日期：2016-04-21 00:00:00

abstract：:The mechanism by which MPF induces nuclear lamin disassembly and nuclear envelope breakdown during mitosis was studied in a frog egg extract in which the transition from interphase to mitosis can be induced by the addition of MPF. Bacterially expressed human nuclear lamin C, assembled in vitro into filaments, showed i...

journal_title：Cell

authors： Ward GE,Kirschner MW

更新日期：1990-05-18 00:00:00

abstract：:Transfection experiments with HSV 1 in which one uses herpes simplex virus (HSV) thymidine kinase (TK) as a selectable prototrophic marker yield two classes of transformed cells: stable and unstable. In this report, we test the hypothesis that the stability phenotype can be explained by virus genome integration into a...

journal_title：Cell

authors： Smiley JR,Steege DA,Juricek DK,Summers WP,Ruddle FH

更新日期：1978-10-01 00:00:00

abstract：:The kinetics of association of epidermal growth factor (EGF) and diferric-transferrin (TF) with clathrin-coated membranes of KB cells were examined using anti-clathrin antibody bound to Staphylococcus aureus. The ligands were bound to cells at 4 degrees C and after warming to 30 degrees C for 5 min, both ligands were ...

journal_title：Cell

authors： Hanover JA,Willingham MC,Pastan I

更新日期：1984-12-01 00:00:00

abstract：:The auditory inner hair cell (IHC) ribbon synapse operates with an exceptional temporal precision and maintains a high level of neurotransmitter release. However, the molecular mechanisms underlying IHC synaptic exocytosis are largely unknown. We studied otoferlin, a predicted C2-domain transmembrane protein, which is...

journal_title：Cell

authors： Roux I,Safieddine S,Nouvian R,Grati M,Simmler MC,Bahloul A,Perfettini I,Le Gall M,Rostaing P,Hamard G,Triller A,Avan P,Moser T,Petit C

更新日期：2006-10-20 00:00:00

abstract：:Conversion of glial cells into functional neurons represents a potential therapeutic approach for replenishing neuronal loss associated with neurodegenerative diseases and brain injury. Previous attempts in this area using expression of transcription factors were hindered by the low conversion efficiency and failure o...

journal_title：Cell

authors： Zhou H,Su J,Hu X,Zhou C,Li H,Chen Z,Xiao Q,Wang B,Wu W,Sun Y,Zhou Y,Tang C,Liu F,Wang L,Feng C,Liu M,Li S,Zhang Y,Xu H,Yao H,Shi L,Yang H

更新日期：2020-04-30 00:00:00

abstract：:Bacterial gene expression depends not only on specific regulatory mechanisms, but also on bacterial growth, because important global parameters such as the abundance of RNA polymerases and ribosomes are all growth-rate dependent. Understanding of these global effects is necessary for a quantitative understanding of ge...

journal_title：Cell

authors： Klumpp S,Zhang Z,Hwa T

更新日期：2009-12-24 00:00:00

abstract：:Treatment of guinea pig neutrophils with pertussis toxin (islet-activating protein; IAP) results in inhibition of N-formyl peptide receptor-mediated release of arachidonic acid and granular enzymes. Inhibition by the toxin is specific, in that responses to the calcium ionophore A23187 are not affected. The action of t...

journal_title：Cell

authors： Bokoch GM,Gilman AG

更新日期：1984-12-01 00:00:00

abstract：:The mitochondrial unfolded protein response (UPRmt) can be triggered in a cell-non-autonomous fashion across multiple tissues in response to mitochondrial dysfunction. The ability to communicate information about the presence of mitochondrial stress enables a global response that can ultimately better protect an organ...

journal_title：Cell

authors： Zhang Q,Wu X,Chen P,Liu L,Xin N,Tian Y,Dillin A

更新日期：2018-08-09 00:00:00

abstract：:Xenopus laevis oocytes were used as a model system to study the intracellular fate of proteins incorporated by endocytosis. We found that the intracellular stability and compartmentation of proteins incorporated by receptor-mediated endocytosis differed substantially from that of proteins incorporated by nonspecific e...

journal_title：Cell

authors： Opresko L,Wiley HS,Wallace RA

更新日期：1980-11-01 00:00:00

abstract：:The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of cellular pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 detects UV-induced pyrimidine dimers in the genome and facilitates nucleotide excision repair. We provide the molecular basis for DDB2 receptor-mediated cyclobutan...

journal_title：Cell

authors： Fischer ES,Scrima A,Böhm K,Matsumoto S,Lingaraju GM,Faty M,Yasuda T,Cavadini S,Wakasugi M,Hanaoka F,Iwai S,Gut H,Sugasawa K,Thomä NH

更新日期：2011-11-23 00:00:00

abstract：:We have cloned and characterized the rat telomerase protein component 1 gene (TLP1), which is related to the gene for Tetrahymena p80. The cDNA encodes a 2629 amino acid sequence and produces the TLP1 proteins p240 and p230. The anti-TLP1 antibody specifically immunoprecipitated the telomerase activity. Moreover, p240...

journal_title：Cell

authors： Nakayama J,Saito M,Nakamura H,Matsuura A,Ishikawa F

更新日期：1997-03-21 00:00:00

abstract：:The immune system can mount T cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well understood. We used yeast-display libraries of peptide-human leukocyte antigen (pHLA) to screen for antigens of "orphan" T cell receptors (TCRs) expressed on TILs from h...

journal_title：Cell

authors： Gee MH,Han A,Lofgren SM,Beausang JF,Mendoza JL,Birnbaum ME,Bethune MT,Fischer S,Yang X,Gomez-Eerland R,Bingham DB,Sibener LV,Fernandes RA,Velasco A,Baltimore D,Schumacher TN,Khatri P,Quake SR,Davis MM,Garcia KC

更新日期：2018-01-25 00:00:00

abstract：:Chromatin assembly factor 1 (CAF-1) and Rtt106 participate in the deposition of newly synthesized histones onto replicating DNA to form nucleosomes. This process is critical for the maintenance of genome stability and inheritance of functionally specialized chromatin structures in proliferating cells. However, the mol...

journal_title：Cell

authors： Li Q,Zhou H,Wurtele H,Davies B,Horazdovsky B,Verreault A,Zhang Z

更新日期：2008-07-25 00:00:00

abstract：:In the mammalian brain, the specification of a single axon and multiple dendrites occurs early in the differentiation of most neuron types. Numerous intracellular signaling events for axon specification have been described in detail. However, the identity of the extracellular factor(s) that initiate neuronal polarity ...

journal_title：Cell

authors： Yi JJ,Barnes AP,Hand R,Polleux F,Ehlers MD

更新日期：2010-07-09 00:00:00

abstract：:The CD4 lymphocyte surface glycoprotein and the lck tyrosine protein kinase p56lck are found as a complex in T lymphocytes. We have defined the domains in both proteins that are responsible for this interaction by coexpressing hybrid and deleted forms of the two proteins in HeLa cells. We have found that the unique 32...

journal_title：Cell

authors： Shaw AS,Amrein KE,Hammond C,Stern DF,Sefton BM,Rose JK

更新日期：1989-11-17 00:00:00

abstract：:Is the Café Scientifique a fashionable by-product of a comfortable age or an indicator of the changing relationship between science and society? ...

journal_title：Cell

authors： Dallas D

更新日期：2006-07-28 00:00:00

abstract：:The role of various segments (gag or v-abl) of the Abelson murine leukemia virus (A-MuLV) genome in both lymphoid cell and fibroblast transformation was examined by deletion of areas from cloned, plasmid DNA representations of the genome. The deleted plasmids were tested by transfection into fibroblasts and by infecti...

journal_title：Cell

authors： Prywes R,Foulkes JG,Rosenberg N,Baltimore D

更新日期：1983-09-01 00:00:00

abstract：:Cells are protected from endoplasmic reticulum stress through the unfolded protein response (UPR). In this issue of Cell, Schinzel, Higuchi-Sanabria, Shalem et al., identify a mechanism that helps cells cope with ER stress but is independent of canonical UPR activation, instead involving the extracellular matrix hyalu...

journal_title：Cell

authors： Koopman M,Hetz C,Nollen EAA

更新日期：2019-11-27 00:00:00

abstract：:Advances in genomic technology have produced an explosion of new information about the genetic basis for human disease, fueling extraordinarily high expectations for improved treatments. This perspective will take brief stock of what genetics/genomics have brought to clinical practice to date and what we might expect ...

journal_title：Cell

authors： Ginsburg D

更新日期：2011-09-30 00:00:00

abstract：:Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTE...

journal_title：Cell

authors： Ciriello G,Gatza ML,Beck AH,Wilkerson MD,Rhie SK,Pastore A,Zhang H,McLellan M,Yau C,Kandoth C,Bowlby R,Shen H,Hayat S,Fieldhouse R,Lester SC,Tse GM,Factor RE,Collins LC,Allison KH,Chen YY,Jensen K,Johnson NB,O

更新日期：2015-10-08 00:00:00

abstract：:The cis-trans isomerization of proline serves as a regulatory switch in signaling pathways. We identify the proline isomerase Fpr4, a member of the FK506 binding protein family in Saccharomyces cerevisiae, as an enzyme which binds the amino-terminal tail of histones H3 and H4 and catalyses the isomerization of H3 prol...

journal_title：Cell

authors： Nelson CJ,Santos-Rosa H,Kouzarides T

更新日期：2006-09-08 00:00:00