Immunogenic structure of the influenza virus hemagglutinin.

abstract：:Significant advances have been made in developing novel therapeutics for cancer treatment, and targeted therapies have revolutionized the treatment of some cancers. Despite the promise, only about five percent of new cancer drugs are approved, and most fail due to lack of efficacy. The indication is that current precl...

journal_title：Cell

authors： Day CP,Merlino G,Van Dyke T

更新日期：2015-09-24 00:00:00

abstract：:Post-translational modifications of histone proteins and exchanges of histone variants of chromatin are central to the regulation of nearly all DNA-templated biological processes. However, the degree and variability of chromatin modifications in specific human immune cells remain largely unknown. Here, we employ a hig...

journal_title：Cell

authors： Cheung P,Vallania F,Warsinske HC,Donato M,Schaffert S,Chang SE,Dvorak M,Dekker CL,Davis MM,Utz PJ,Khatri P,Kuo AJ

更新日期：2018-05-31 00:00:00

abstract：:Ebola virus (EBOV) remains a public health threat. We performed a longitudinal study of B cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection induced lasting EBOV-specific immunoglobulin G (IgG) antibodies, but their subclass composition changed over time, with IgG1 persisting, IgG3 r...

journal_title：Cell

authors： Davis CW,Jackson KJL,McElroy AK,Halfmann P,Huang J,Chennareddy C,Piper AE,Leung Y,Albariño CG,Crozier I,Ellebedy AH,Sidney J,Sette A,Yu T,Nielsen SCA,Goff AJ,Spiropoulou CF,Saphire EO,Cavet G,Kawaoka Y,Mehta AK,

更新日期：2019-05-30 00:00:00

abstract：:The V(D)J recombinase subunits Rag-1 and Rag-2 mediate assembly of antigen receptor gene segments. We studied the mechanisms of DNA recognition by Rag-1/Rag-2 using surface plasmon resonance. The critical step for signal recognition is binding of Rag-1 to the nonamer. This is achieved by a region of Rag-1 homologous t...

journal_title：Cell

authors： Spanopoulou E,Zaitseva F,Wang FH,Santagata S,Baltimore D,Panayotou G

更新日期：1996-10-18 00:00:00

abstract：:The role of S. cerevisiae YDJ1 protein (YDJ1p) in polypeptide translocation across membranes has been examined. A conditional ydj1 mutant strain (ydj1-151TS) is defective for import of several polypeptides into mitochondria and alpha factor into the endoplasmic reticulum at 37 degrees C. These defects are suppressed b...

journal_title：Cell

authors： Caplan AJ,Cyr DM,Douglas MG

更新日期：1992-12-24 00:00:00

abstract：:A clonally diverse anticipatory repertoire in which each lymphocyte bears a unique antigen receptor is the central feature of the adaptive immune system that evolved in our vertebrate ancestors. The survival advantage gained through adding this type of adaptive immune system to a pre-existing innate immune system led ...

journal_title：Cell

authors： Cooper MD,Alder MN

更新日期：2006-02-24 00:00:00

abstract：:It remains largely unknown how large-scale tissue movements during development emerge from the interplay of different tensile forces associated with actomyosin networks. Solon et al. (2009) now report that a ratchet-like mechanism drives the movement of epithelial sheets during dorsal closure in embryos of the fruit f...

journal_title：Cell

authors： Rauzi M,Lecuit T

更新日期：2009-06-26 00:00:00

abstract：:Double-strand break (DSB) repair is critical for maintaining genomic integrity and requires the processing of the 5' DSB ends. Recent studies have shed light on the mechanism and regulation of DNA end processing during DSB repair by homologous recombination. ...

journal_title：Cell

authors： Bernstein KA,Rothstein R

更新日期：2009-05-29 00:00:00

abstract：:Kinetochores connect centromeric nucleosomes with mitotic-spindle microtubules through conserved, cross-interacting protein subassemblies. In budding yeast, the heterotetrameric MIND complex (Mtw1, Nnf1, Nsl1, Dsn1), ortholog of the metazoan Mis12 complex, joins the centromere-proximal components, Mif2 and COMA, with ...

journal_title：Cell

authors： Dimitrova YN,Jenni S,Valverde R,Khin Y,Harrison SC

更新日期：2016-11-03 00:00:00

abstract：:When treated with the synthetic glucocorticoid dexamethasone, HT1080 human fibrosarcoma cells show changes in morphology, adhesion, and the extracellular matrix. Dexamethasone treatment results in a tenfold increase in the rate of fibronectin biosynthesis in HT1080 cells and a twofold increase in untransformed, normal...

journal_title：Cell

authors： Oliver N,Newby RF,Furcht LT,Bourgeois S

更新日期：1983-05-01 00:00:00

abstract：:SR proteins constitute a family of pre-mRNA splicing factors that play important roles in both constitutive and regulated splicing. Here, we describe one member of the family, which we call SRp38, with unexpected properties. Unlike other SR proteins, SRp38 cannot activate splicing and is essentially inactive in splici...

journal_title：Cell

authors： Shin C,Manley JL

更新日期：2002-11-01 00:00:00

abstract：:Two decades of research identified more than a dozen clock genes and defined a biochemical feedback mechanism of circadian oscillator function. To identify additional clock genes and modifiers, we conducted a genome-wide small interfering RNA screen in a human cellular clock model. Knockdown of nearly 1000 genes reduc...

journal_title：Cell

authors： Zhang EE,Liu AC,Hirota T,Miraglia LJ,Welch G,Pongsawakul PY,Liu X,Atwood A,Huss JW 3rd,Janes J,Su AI,Hogenesch JB,Kay SA

更新日期：2009-10-02 00:00:00

abstract：:The memory for sensitization of the gill withdrawal reflex in Aplysia is reflected in facilitation of the monosynaptic connection between the sensory and motor neurons of the reflex. The switch from short- to long-term facilitation requires activation of CREB1, derepression of ApCREB2, and induction of ApC/EBP. In sea...

journal_title：Cell

authors： Bartsch D,Ghirardi M,Casadio A,Giustetto M,Karl KA,Zhu H,Kandel ER

更新日期：2000-11-10 00:00:00

abstract：:Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate effects of the PPARγ agonist class of antidiabetic drugs. Does this new property improve FGF21's fledgling clinical prospe...

journal_title：Cell

authors： Qiang L,Accili D

更新日期：2012-02-03 00:00:00

abstract：:When the human beta-globin gene is transfected into Hela cells, no beta-globin RNA is detected unless the gene is linked to a viral transcription enhancer. In this paper we show that trans-acting adenovirus and herpesvirus (pseudorabies) transcriptional regulatory proteins can circumvent this enhancer requirement for ...

journal_title：Cell

authors： Green MR,Treisman R,Maniatis T

更新日期：1983-11-01 00:00:00

abstract：:Phosphorylation of histone H3 serine 10 correlates with chromosome condensation and is required for normal chromosome segregation in Tetrahymena. This phosphorylation is dependent upon activation of the NIMA kinase in Aspergillus nidulans. NIMA expression also induces Ser-10 phosphorylation inappropriately in S phase-...

journal_title：Cell

authors： De Souza CP,Osmani AH,Wu LP,Spotts JL,Osmani SA

更新日期：2000-08-04 00:00:00

abstract：:Cloned, sequenced mouse satellite DNA exhibits properties characteristic of molecules that possess a stable curvature. Circularly permuted fragments containing the region predicted to bend were used to map the curvature relative to DNA sequence. The altered mobility of these fragments in polyacrylamide gels is reverse...

journal_title：Cell

authors： Radic MZ,Lundgren K,Hamkalo BA

更新日期：1987-09-25 00:00:00

abstract：:Beta-arrestin1 is a multifunctional protein critically involved in signal transduction. Recently, it is also identified as a nuclear transcriptional regulator, but the underlying mechanisms and physiological significance remain to be explored. Here, we identified beta-arrestin1 as an evolutionarily conserved protein e...

journal_title：Cell

authors： Yue R,Kang J,Zhao C,Hu W,Tang Y,Liu X,Pei G

更新日期：2009-10-30 00:00:00

abstract：:The messenger RNA coding for the precursor of the small subunit of ribulose--1,5--bisphosphate (Ru-P2) carboxylase has been partially purified from pea leaves. The mRNA has a size of 11.5S, is approximately 800 nucleotides long and, on cell-free translation, directs the synthesis of a single major polypeptide of 20,00...

journal_title：Cell

authors： Cashmore AR

更新日期：1979-06-01 00:00:00

abstract：:Neurotrophic factors are essential for neuronal survival and function. Recent data have demonstrated that the product of the tyrosine kinase trk proto-oncogene binds NGF and is a component of the high affinity NGF receptor. Analysis of the trkB gene product, gp145trkB, in NIH 3T3 cells indicates that this tyrosine kin...

journal_title：Cell

authors： Soppet D,Escandon E,Maragos J,Middlemas DS,Reid SW,Blair J,Burton LE,Stanton BR,Kaplan DR,Hunter T,Nikolics K,Parada LF

更新日期：1991-05-31 00:00:00

abstract：:Pancreatic beta cell-surface expression of glucose transporter 2 (Glut-2) is essential for glucose-stimulated insulin secretion, thereby controlling blood glucose homeostasis in response to dietary intake. We show that the murine GlcNAcT-IVa glycosyltransferase is required for Glut-2 residency on the beta cell surface...

journal_title：Cell

authors： Ohtsubo K,Takamatsu S,Minowa MT,Yoshida A,Takeuchi M,Marth JD

更新日期：2005-12-29 00:00:00

abstract：:Xenopus laevis oocytes respond to high temperature (greater than 31 degrees C) by the synthesis of one major (70 kilodalton) protein and by a gradual reduction in the rate of normal protein synthesis. In contrast with most other cells, the heat-shock response of Xenopus oocytes is controlled exclusively at the transla...

journal_title：Cell

authors： Bienz M,Gurdon JB

更新日期：1982-07-01 00:00:00

abstract：:The quest to slow aging has come far, and what used to be the domain of science fiction writers and snake oil salesmen may soon become science fact. Innovative new approaches, such as the use of the very short-lived African killifish (Harel et al.), are bridging the translational gap and bring the promise of healthy l...

journal_title：Cell

authors： Wang AM,Promislow DEL,Kaeberlein M

更新日期：2015-02-26 00:00:00

abstract：:Social interactions occur between multiple individuals, but what is the detailed relationship between the neural dynamics across their brains? To address this question across timescales and levels of neural activity, we used wireless electrophysiology to simultaneously record from pairs of bats engaged in a wide range...

journal_title：Cell

authors： Zhang W,Yartsev MM

更新日期：2019-07-11 00:00:00

abstract：:The mRNAs from two yeast mitochondrial genes cob-box (cytochrome b) and oxi-3 (cytochrome oxidase 40,000 dalton subunit) are processed from large (7-10 kb) precursors. Certain mutations in each gene block the maturation of the RNAs from both genes at a variety of specific steps. The pleiotropic cytochrome b mutants se...

journal_title：Cell

authors： Church GM,Slonimski PP,Gilbert W

更新日期：1979-12-01 00:00:00

abstract：:An examination of Abelson murine leukemia virus (A-MuL V)-hematopoietic cell interaction in cultures of fetal tissues reveals that A-MuLV can stimulate the formation of two different types of colonies. One type of colony is white and composed of A-MuLV-transformed lymphoid cells that can develop into established cell ...

journal_title：Cell

authors： Waneck GL,Rosenberg N

更新日期：1981-10-01 00:00:00

abstract：:Excessive sun tanning can result in addictive behavior. In this issue of Cell, Fell et al. utilize a combination of behavioral pharmacology and transgenic mice to demonstrate that chronic UV light exposure recruits p53 signaling in keratinocytes, subsequently increasing β-endorphin signaling at opioid receptors, and p...

journal_title：Cell

authors： Tejeda HA,Bonci A

更新日期：2014-06-19 00:00:00

abstract：:Pure primary mesenchymal cells from definitive streak stage chick embryos have been prepared free of epiblast and hypoblast cells. These cells have the potential in culture to differentiate into erythroid cells, beating heart muscle tissue, chondrocytes and epithelial cells. Transformation in vitro of pure primary mes...

journal_title：Cell

authors： Keane RW,Lindblad PC,Pierik LT,Ingram VM

更新日期：1979-08-01 00:00:00

abstract：:The molecular basis for membrane association of pp60v-src, the transforming protein of Rous sarcoma virus, was investigated in a cell-free system. Newly synthesized pp60v-src polypeptide, produced by in vitro translation of src mRNA, rapidly bound to plasma membranes. Binding was saturable and dependent on the presenc...

journal_title：Cell

authors： Resh MD

更新日期：1989-07-28 00:00:00

abstract：:Autophagy (literally self-eating) has diverse cytoprotective functions but also is linked to programmed cell death (PCD). In this issue, Qu et al. (2007) analyze the role of autophagy in PCD during development. Unexpectedly they find that autophagy induces apoptotic cells to present a signal to ensure their clearance,...

journal_title：Cell

authors： Yoshimori T

更新日期：2007-03-09 00:00:00