Abstract：
:Post-translational modifications of histone proteins and exchanges of histone variants of chromatin are central to the regulation of nearly all DNA-templated biological processes. However, the degree and variability of chromatin modifications in specific human immune cells remain largely unknown. Here, we employ a highly multiplexed mass cytometry analysis to profile the global levels of a broad array of chromatin modifications in primary human immune cells at the single-cell level. Our data reveal markedly different cell-type- and hematopoietic-lineage-specific chromatin modification patterns. Differential analysis between younger and older adults shows that aging is associated with increased heterogeneity between individuals and elevated cell-to-cell variability in chromatin modifications. Analysis of a twin cohort unveils heritability of chromatin modifications and demonstrates that aging-related chromatin alterations are predominantly driven by non-heritable influences. Together, we present a powerful platform for chromatin and immunology research. Our discoveries highlight the profound impacts of aging on chromatin modifications.
journal_name
Celljournal_title
Cellauthors
Cheung P,Vallania F,Warsinske HC,Donato M,Schaffert S,Chang SE,Dvorak M,Dekker CL,Davis MM,Utz PJ,Khatri P,Kuo AJdoi
10.1016/j.cell.2018.03.079subject
Has Abstractpub_date
2018-05-31 00:00:00pages
1385-1397.e14issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(18)30451-3journal_volume
173pub_type
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