Abstract：
:Inward rectifier K+ channels mediate the K+ conductance at resting potential in many types of cell. Since these K+ channels do not pass outward currents (inward rectification) when the cell membrane is depolarized beyond a trigger threshold, they play an important role in controlling excitability. Both a highly voltage-dependent block by intracellular Mg2+ and an endogenous gating process are presently assumed to underly inward rectification. It is shown that strong voltage dependence of rectification found under physiological conditions is predominantly due to the effect of intracellular spermine. Physiological concentrations of free spermine mediate strong rectification of IRK1 inward rectifier K+ channels even in the absence of free Mg2+ and in IRK1 mutant channels that have no endogenous rectification.
journal_name
Celljournal_title
Cellauthors
Fakler B,Brändle U,Glowatzki E,Weidemann S,Zenner HP,Ruppersberg JPdoi
10.1016/0092-8674(95)90459-xsubject
Has Abstractpub_date
1995-01-13 00:00:00pages
149-54issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(95)90459-Xjournal_volume
80pub_type
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