Abstract:
:To determine whether phylogenetically conservative H-Y antigen plays any part in gonadal differentiation among the nonmammalian vertebrates, we studied expression and binding of H-Y in the frog, Xenopus laevis. Soluble H-Y obtained from mouse testis and soluble H-W from chicken ovary bound specifically to cells of the ZZ testis from normal Xenopus males. In addition, H-Y (H-W) appeared selectively in the ovaries of ZZ genetic males that had been induced to become functional females by exposure to estradiol. Our observations suggest that H-Y (H-W) antigen may be involved in differentiation of the ZW ovary, and also that synthesis of H-Y may be regulated by sex steroids in the primitive ZW/ZZ species.
journal_name
Celljournal_title
Cellauthors
Wachtel SS,Bresler PA,Koide SSdoi
10.1016/0092-8674(80)90332-3subject
Has Abstractpub_date
1980-07-01 00:00:00pages
859-64issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(80)90332-3journal_volume
20pub_type
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