当前位置： SCI文献检索 > CELL期刊下所有文献 > Partially edited mRNAs for cytochrome b and subunit III of cytochrome oxidase from Leishmania tarentolae mitochondria: RNA editing intermediates.

Partially edited mRNAs for cytochrome b and subunit III of cytochrome oxidase from Leishmania tarentolae mitochondria: RNA editing intermediates.

Abstract：

:Partially edited mRNAs were selected by the polymerase chain reaction and sequenced. In the case of cytochrome b, 102 out of 106 clones displayed patterns of editing that were consistent with a strictly progressive 3' to 5' editing process, as predicted by the guide RNA model of RNA editing. In the case of cytochrome oxidase subunit III (COIII), 177 out of 304 clones displayed strictly progressive 3' to 5' patterns of editing. However, the remaining 127 COIII clones displayed unexpected patterns in which upstream editing preceded downstream editing, uridines were inserted at sites not normally edited, and purine residues were deleted. We suggest that many of these RNAs are produced by normal 3' to 5' editing of the COIII mRNA with incorrect guide RNA molecules.

journal_name

Cell

journal_title

Cell

authors

Sturm NR,Simpson L

doi

10.1016/0092-8674(90)90197-m

subject

Has Abstract

pub_date

1990-06-01 00:00:00

pages

871-8

issue

5

eissn

0092-8674

issn

1097-4172

pii

0092-8674(90)90197-M

journal_volume

61

pub_type

杂志文章

相关文献

CELL文献大全
  • Small RNA-mediated activation of sugar phosphatase mRNA regulates glucose homeostasis.

    abstract：:Glucose homeostasis is strictly controlled in all domains of life. Bacteria that are unable to balance intracellular sugar levels and deal with potentially toxic phosphosugars cease growth and risk being outcompeted. Here, we identify the conserved haloacid dehalogenase (HAD)-like enzyme YigL as the previously hypothe...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2013.03.003

    authors： Papenfort K,Sun Y,Miyakoshi M,Vanderpool CK,Vogel J

    更新日期：2013-04-11 00:00:00

  • Hippo pathway activity influences liver cell fate.

    abstract：:The Hippo-signaling pathway is an important regulator of cellular proliferation and organ size. However, little is known about the role of this cascade in the control of cell fate. Employing a combination of lineage tracing, clonal analysis, and organoid culture approaches, we demonstrate that Hippo pathway activity i...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2014.03.060

    authors： Yimlamai D,Christodoulou C,Galli GG,Yanger K,Pepe-Mooney B,Gurung B,Shrestha K,Cahan P,Stanger BZ,Camargo FD

    更新日期：2014-06-05 00:00:00

  • Chicken myeloid stem cells infected by retroviruses carrying the v-fps oncogene do not require exogenous growth factors to differentiate in vitro.

    abstract：:To determine the function of c-fps in chicken macrophages and granulocytic cells we have infected chicken bone marrow cells with retroviruses containing the v-fps oncogene. Normal chicken macrophage progenitors, M-CFCs, give rise to macrophage colonies in semisolid cultures when macrophage colony stimulating factor (M...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(86)90494-0

    authors： Carmier JF,Samarut J

    更新日期：1986-01-17 00:00:00

  • Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.

    abstract：:Dysfunction and loss of insulin-producing pancreatic beta cells represent hallmarks of diabetes mellitus. Here, we show that mice lacking the mitogen-activated protein kinase (MAPK) p38delta display improved glucose tolerance due to enhanced insulin secretion from pancreatic beta cells. Deletion of p38delta results in...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2008.11.018

    authors： Sumara G,Formentini I,Collins S,Sumara I,Windak R,Bodenmiller B,Ramracheya R,Caille D,Jiang H,Platt KA,Meda P,Aebersold R,Rorsman P,Ricci R

    更新日期：2009-01-23 00:00:00

  • Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage.

    abstract：:The mitotic checkpoint ensures proper chromosome segregation by delaying anaphase until chromosomes are aligned on the spindle. Following prolonged spindle damage, however, cells eventually exit mitosis and undergo apoptosis. We show here that a murine homolog of the yeast mitotic checkpoint gene BUB1 localizes to the...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(00)80255-x

    authors： Taylor SS,McKeon F

    更新日期：1997-05-30 00:00:00

  • Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes.

    abstract：:Wnt signaling plays critical roles in development of various organs and pathogenesis of many diseases, and augmented Wnt signaling has recently been implicated in mammalian aging and aging-related phenotypes. We here report that complement C1q activates canonical Wnt signaling and promotes aging-associated decline in ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2012.03.047

    authors： Naito AT,Sumida T,Nomura S,Liu ML,Higo T,Nakagawa A,Okada K,Sakai T,Hashimoto A,Hara Y,Shimizu I,Zhu W,Toko H,Katada A,Akazawa H,Oka T,Lee JK,Minamino T,Nagai T,Walsh K,Kikuchi A,Matsumoto M,Botto M,Shiojima

    更新日期：2012-06-08 00:00:00

  • Linking retroelements to autoimmunity.

    abstract：:In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to ...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.cell.2008.08.010

    authors： Bhoj VG,Chen ZJ

    更新日期：2008-08-22 00:00:00

  • Intrinsic Immunity Shapes Viral Resistance of Stem Cells.

    abstract：:Stem cells are highly resistant to viral infection compared to their differentiated progeny; however, the mechanism is mysterious. Here, we analyzed gene expression in mammalian stem cells and cells at various stages of differentiation. We find that, conserved across species, stem cells express a subset of genes previ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2017.11.018

    authors： Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM

    更新日期：2018-01-25 00:00:00

  • Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

    abstract：:TGF-beta signaling controls a plethora of cellular responses and figures prominently in animal development. Recent cellular, biochemical, and structural studies have revealed significant insight into the mechanisms of the activation of TGF-beta receptors through ligand binding, the activation of Smad proteins through ...

    journal_title：Cell

    pub_type： 杂志文章,评审

    doi：10.1016/s0092-8674(03)00432-x

    authors： Shi Y,Massagué J

    更新日期：2003-06-13 00:00:00

  • Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.

    abstract：:Notch signaling is broadly used to regulate cell-fate decisions. We have identified a gene, rumi, with a temperature-sensitive Notch phenotype. At 28 degrees C-30 degrees C, rumi clones exhibit a full-blown loss of Notch signaling in all tissues tested. However, at 18 degrees C only a mild Notch phenotype is evident. ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2007.12.016

    authors： Acar M,Jafar-Nejad H,Takeuchi H,Rajan A,Ibrani D,Rana NA,Pan H,Haltiwanger RS,Bellen HJ

    更新日期：2008-01-25 00:00:00

  • Influence of metabolism on epigenetics and disease.

    abstract：:Chemical modifications of histones and DNA, such as histone methylation, histone acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of the enzymes that add or remove such chemical modifications are known, or might be suspected, to be sensitive to changes in intracellular metaboli...

    journal_title：Cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.cell.2013.03.004

    authors： Kaelin WG Jr,McKnight SL

    更新日期：2013-03-28 00:00:00

  • Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.

    abstract：:A complex interplay of environmental factors impacts the metabolism of human cells, but neither traditional culture media nor mouse plasma mimic the metabolite composition of human plasma. Here, we developed a culture medium with polar metabolite concentrations comparable to those of human plasma (human plasma-like me...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2017.03.023

    authors： Cantor JR,Abu-Remaileh M,Kanarek N,Freinkman E,Gao X,Louissaint A Jr,Lewis CA,Sabatini DM

    更新日期：2017-04-06 00:00:00

  • Genetic control of MHC class II expression.

    abstract：:The presentation of peptides to T cells by MHC class II molecules is of critical importance in specific recognition by the immune system. Expression of class II molecules is exquisitely controlled at the transcriptional level. A large set of proteins interact with the promoters of class II genes. The most important of...

    journal_title：Cell

    pub_type： 杂志文章,评审

    doi：10.1016/s0092-8674(02)00696-7

    authors： Ting JP,Trowsdale J

    更新日期：2002-04-01 00:00:00

  • Multilevel modulation of a sensory motor circuit during C. elegans sleep and arousal.

    abstract：:Sleep is characterized by behavioral quiescence, homeostasis, increased arousal threshold, and rapid reversibility. Understanding how these properties are encoded by a neuronal circuit has been difficult, and no single molecular or neuronal pathway has been shown to be responsible for the regulation of sleep. Taking a...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2013.11.036

    authors： Cho JY,Sternberg PW

    更新日期：2014-01-16 00:00:00

  • Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP.

    abstract：:Telomerase is the ribonucleoprotein enzyme that replenishes telomeric DNA and maintains genome integrity. Minimally, telomerase activity requires a templating RNA and a catalytic protein. Additional proteins are required for activity on telomeres in vivo. Here, we report that the Pop1, Pop6, and Pop7 proteins, known c...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2016.04.018

    authors： Lemieux B,Laterreur N,Perederina A,Noël JF,Dubois ML,Krasilnikov AS,Wellinger RJ

    更新日期：2016-05-19 00:00:00

  • Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues.

    abstract：:Constitutive egress of bone marrow (BM)-resident hematopoietic stem and progenitor cells (HSPCs) into the blood is a well-established phenomenon, but the ultimate fate and functional relevance of circulating HSPCs is largely unknown. We show that mouse thoracic duct (TD) lymph contains HSPCs that possess short- and lo...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2007.09.047

    authors： Massberg S,Schaerli P,Knezevic-Maramica I,Köllnberger M,Tubo N,Moseman EA,Huff IV,Junt T,Wagers AJ,Mazo IB,von Andrian UH

    更新日期：2007-11-30 00:00:00

  • Determination of the amount of homology required for recombination in bacteriophage T4.

    abstract：:Homology is an important feature of recombination. We have used the rll cistrons of bacteriophage T4 to determine the extent of homology required for recombination. We varied the amount of homologous DNA available for recombination in both marker rescue experiments and deletion-by-deletion crosses. Our results suggest...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(82)90401-9

    authors： Singer BS,Gold L,Gauss P,Doherty DH

    更新日期：1982-11-01 00:00:00

  • Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes.

    abstract：:The origin recognition complex (ORC) is required to initiate eukaryotic DNA replication and also engages in transcriptional silencing in S. cerevisiae. We observed a striking preferential but not exclusive association of Drosophila ORC2 with heterochromatin on interphase and mitotic chromosomes. HP1, a heterochromatin...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(00)80415-8

    authors： Pak DT,Pflumm M,Chesnokov I,Huang DW,Kellum R,Marr J,Romanowski P,Botchan MR

    更新日期：1997-10-31 00:00:00

  • A mechanism for gene-environment interaction in the etiology of congenital scoliosis.

    abstract：:Congenital scoliosis, a lateral curvature of the spine caused by vertebral defects, occurs in approximately 1 in 1,000 live births. Here we demonstrate that haploinsufficiency of Notch signaling pathway genes in humans can cause this congenital abnormality. We also show that in a mouse model, the combination of this g...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2012.02.054

    authors： Sparrow DB,Chapman G,Smith AJ,Mattar MZ,Major JA,O'Reilly VC,Saga Y,Zackai EH,Dormans JP,Alman BA,McGregor L,Kageyama R,Kusumi K,Dunwoodie SL

    更新日期：2012-04-13 00:00:00

  • Organization and structure of an E. coli tRNA operon containing seven tRNA genes.

    abstract：:The structure and organization on the Escherichia coli chromosome of the gene cluster coding for two methionine tRNAs (tRNAmMet), four glutamine tRNAs (two tRNA1Gln and two tRNA2Gln), and a previously unidentified tRNA (called tRNAx) have been studied by restriction enzyme analysis and DNA sequencing, utilizing a spec...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(81)90288-9

    authors： Nakajima N,Ozeki H,Shimura Y

    更新日期：1981-01-01 00:00:00

  • Behind the movement.

    abstract：:This year, the Albert Lasker Basic Medical Research Award will be shared by Michael Sheetz, James Spudich, and Ronald Vale for discoveries concerning the biophysical actions of cytoskeletal motor-protein machines that move cargo within cells, contract muscles, and enable cell motility. ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2012.08.031

    authors： Ringe D,Petsko GA

    更新日期：2012-09-14 00:00:00

  • A Smad transcriptional corepressor.

    abstract：:Following TGFbeta receptor-mediated phosphorylation and association with Smad4, Smad2 moves into the nucleus, binds to target promoters in association with DNA-binding cofactors, and recruits coactivators such as p300/CBP to activate transcription. We identified the homeodomain protein TGIF as a Smad2-binding protein ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(00)80712-6

    authors： Wotton D,Lo RS,Lee S,Massagué J

    更新日期：1999-04-02 00:00:00

  • MEF2 is an in vivo immune-metabolic switch.

    abstract：:Infections disturb metabolic homeostasis in many contexts, but the underlying connections are not completely understood. To address this, we use paired genetic and computational screens in Drosophila to identify transcriptional regulators of immunity and pathology and their associated target genes and physiologies. We...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2013.09.007

    authors： Clark RI,Tan SW,Péan CB,Roostalu U,Vivancos V,Bronda K,Pilátová M,Fu J,Walker DW,Berdeaux R,Geissmann F,Dionne MS

    更新日期：2013-10-10 00:00:00

  • Subnucleosomal structures and nucleosome asymmetry across a genome.

    abstract：:Genes are packaged into nucleosomal arrays, each nucleosome typically having two copies of histones H2A, H2B, H3, and H4. Histones have distinct posttranslational modifications, variant isoforms, and dynamics. Whether each histone copy within a nucleosome has distinct properties, particularly in relation to the direct...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2014.10.054

    authors： Rhee HS,Bataille AR,Zhang L,Pugh BF

    更新日期：2014-12-04 00:00:00

  • Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway.

    abstract：:We have generated mice lacking H2-M complexes, critical facilitators of peptide loading onto major histo-compatibility complex class II molecules. Ab molecules in these mice matured into stable complexes and were efficiently expressed at the cell surface. Most carried a single peptide derived from the class II-associa...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(00)81029-6

    authors： Miyazaki T,Wolf P,Tourne S,Waltzinger C,Dierich A,Barois N,Ploegh H,Benoist C,Mathis D

    更新日期：1996-02-23 00:00:00

  • TFIIH plays an essential role in RNA polymerase I transcription.

    abstract：:TFIIH is a multisubunit protein complex that plays an essential role in nucleotide excision repair and transcription of protein-coding genes. Here, we report that TFIIH is also required for ribosomal RNA synthesis in vivo and in vitro. In yeast, pre-rRNA synthesis is impaired in TFIIH ts strains. In a mouse, part of c...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(02)00729-8

    authors： Iben S,Tschochner H,Bier M,Hoogstraten D,Hozák P,Egly JM,Grummt I

    更新日期：2002-05-03 00:00:00

  • Blinded by the Light: The Growing Complexity of p53.

    abstract：:While the tumor suppressor functions of p53 have long been recognized, the contribution of p53 to numerous other aspects of disease and normal life is only now being appreciated. This burgeoning range of responses to p53 is reflected by an increasing variety of mechanisms through which p53 can function, although the a...

    journal_title：Cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.cell.2009.04.037

    authors： Vousden KH,Prives C

    更新日期：2009-05-01 00:00:00

  • The Implication of Early Chromatin Changes in X Chromosome Inactivation.

    abstract：:During development, the precise relationships between transcription and chromatin modifications often remain unclear. We use the X chromosome inactivation (XCI) paradigm to explore the implication of chromatin changes in gene silencing. Using female mouse embryonic stem cells, we initiate XCI by inducing Xist and then...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2018.11.041

    authors： Żylicz JJ,Bousard A,Žumer K,Dossin F,Mohammad E,da Rocha ST,Schwalb B,Syx L,Dingli F,Loew D,Cramer P,Heard E

    更新日期：2019-01-10 00:00:00

  • Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins.

    abstract：:During asymmetric cell divisions, mitotic spindles align along the axis of polarization. In invertebrates, spindle positioning requires Pins or related proteins and a G protein alpha subunit. A mammalian Pins, called LGN, binds Galphai and also interacts through an N-terminal domain with the microtubule binding protei...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2004.10.028

    authors： Du Q,Macara IG

    更新日期：2004-11-12 00:00:00

  • The molecular basis of I-R hybrid dysgenesis in Drosophila melanogaster: identification, cloning, and properties of the I factor.

    abstract：:We have analyzed two mutations of the white-eye gene, which arose in flies subject to I-R hybrid dysgenesis. These mutations are associated with insertions of apparently identical 5.4 kb sequences, which we have cloned. We believe that these insertions are copies of the I factor controlling I-R hybrid dysgenesis. The ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(84)90536-1

    authors： Bucheton A,Paro R,Sang HM,Pelisson A,Finnegan DJ

    更新日期：1984-08-01 00:00:00