Abstract：
:Sleep is characterized by behavioral quiescence, homeostasis, increased arousal threshold, and rapid reversibility. Understanding how these properties are encoded by a neuronal circuit has been difficult, and no single molecular or neuronal pathway has been shown to be responsible for the regulation of sleep. Taking advantage of the well-mapped neuronal connections of Caenorhabditis elegans and the sleep-like states in this animal, we demonstrate the changed properties of both sensory neurons and downstream interneurons that mediate sleep and arousal. The ASH sensory neuron displays reduced sensitivity to stimuli in the sleep-like state, and the activity of the corresponding interneurons in ASH's motor circuit becomes asynchronous. Restoration of interneuron synchrony is sufficient for arousal. The multilevel circuit depression revealed provides an elegant strategy to promote a robust decrease in arousal while allowing for rapid reversibility of the sleep state.
journal_name
Celljournal_title
Cellauthors
Cho JY,Sternberg PWdoi
10.1016/j.cell.2013.11.036subject
Has Abstractpub_date
2014-01-16 00:00:00pages
249-60issue
1-2eissn
0092-8674issn
1097-4172pii
S0092-8674(13)01520-1journal_volume
156pub_type
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