Postnatal development of a demyelinating disease in avian spinal cord chimeras.

abstract：:In response to extracellular cues, signal transduction activates downstream transcription factors like c-Jun to induce expression of target genes. We demonstrate that the ATAC (Ada two A containing) histone acetyltransferase (HAT) complex serves as a transcriptional cofactor for c-Jun at the Jun N-terminal kinase (JNK...

journal_title：Cell

authors： Suganuma T,Mushegian A,Swanson SK,Abmayr SM,Florens L,Washburn MP,Workman JL

更新日期：2010-09-03 00:00:00

abstract：:We present evidence that the genes encoding U3 snRNA in plants are transcribed by RNA polymerase III (pol III) and not by RNA polymerase II (pol II) as in vertebrates or lower eukaryotes. The U3 gene is the only known example of a gene transcribed by different polymerases in different organisms. It is possible to conv...

journal_title：Cell

authors： Kiss T,Marshallsay C,Filipowicz W

更新日期：1991-05-03 00:00:00

abstract：:The small molecular weight RNAs of the HeLa cell have been located in specific subcellular fractions. SnA is located in the nucleolus and is partially bonded to nucleolar 28S RNA. SnD, the most abundant of the small nuclear RNAs, is partially released from the nucleus when the nuclear preparation is briefly warmed. Sn...

journal_title：Cell

authors： Zieve G,Penman S

更新日期：1976-05-01 00:00:00

abstract：:The existence of pseudogenes and the observation of intron loss suggest that RNA can serve as an intermediate in recombination. We used a HIS3 reporter gene to show that RNA-mediated recombination occurs in yeast. His3+ prototroph formation required transcription and expression of the retrotransposon Ty. Two RNA-media...

journal_title：Cell

authors： Derr LK,Strathern JN,Garfinkel DJ

更新日期：1991-10-18 00:00:00

abstract：:Excessive sun tanning can result in addictive behavior. In this issue of Cell, Fell et al. utilize a combination of behavioral pharmacology and transgenic mice to demonstrate that chronic UV light exposure recruits p53 signaling in keratinocytes, subsequently increasing β-endorphin signaling at opioid receptors, and p...

journal_title：Cell

authors： Tejeda HA,Bonci A

更新日期：2014-06-19 00:00:00

abstract：:A complete human gamma 1 heavy chain gene (HIG1) was transferred into mouse cells by protoplast fusion. The HIG1 gene was strongly expressed in mouse myeloma cells but not in mouse fibroblasts (L cells). Nuclear extracts from myeloma cells were injected into L cell transformants containing one copy of the HIG1 gene; t...

journal_title：Cell

authors： Maeda H,Kitamura D,Kudo A,Araki K,Watanabe T

更新日期：1986-04-11 00:00:00

abstract：:Xenopus laevis oocytes respond to high temperature (greater than 31 degrees C) by the synthesis of one major (70 kilodalton) protein and by a gradual reduction in the rate of normal protein synthesis. In contrast with most other cells, the heat-shock response of Xenopus oocytes is controlled exclusively at the transla...

journal_title：Cell

authors： Bienz M,Gurdon JB

更新日期：1982-07-01 00:00:00

abstract：:The larval salivary glands of Drosophila melanogaster, which are widely used for cytogenic studies, are also useful for studying the regulation of specific protein synthesis during differentiation. These glands synthesize and secrete massive amounts of a glue which attaches the pupae to the substrate during metamorpho...

journal_title：Cell

authors： Beckendorf SK,Kafatos FC

更新日期：1976-11-01 00:00:00

abstract：:Transcription termination by bacterial RNA polymerase (RNAP) occurs at sequences coding for a GC-rich RNA hairpin followed by a U-rich tract. We used single-molecule techniques to investigate the mechanism by which three representative terminators (his, t500, and tR2) destabilize the elongation complex (EC). For his a...

journal_title：Cell

authors： Larson MH,Greenleaf WJ,Landick R,Block SM

更新日期：2008-03-21 00:00:00

abstract：:Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE) is implicated in geographic atrophy (GA), an advanced form of age-related macular degeneration that causes blindness in millions of individuals. The mechanism of Alu RNA-induced cytotoxicity is unknown. Here we show that DICER1 def...

journal_title：Cell

authors： Tarallo V,Hirano Y,Gelfand BD,Dridi S,Kerur N,Kim Y,Cho WG,Kaneko H,Fowler BJ,Bogdanovich S,Albuquerque RJ,Hauswirth WW,Chiodo VA,Kugel JF,Goodrich JA,Ponicsan SL,Chaudhuri G,Murphy MP,Dunaief JL,Ambati BK,Ogura Y

更新日期：2012-05-11 00:00:00

abstract：:Serum response factor (SRF) forms a ternary complex at the c-fos serum response element (SRE) with an accessory factor, Elk-1. We constructed altered-binding specificity derivatives of SRF and Elk-1 that form a ternary complex at a mutated, inactive SRE; like Elk-1, the Elk-1 variant only binds its target as part of a...

journal_title：Cell

authors： Hill CS,Marais R,John S,Wynne J,Dalton S,Treisman R

更新日期：1993-04-23 00:00:00

abstract：:Mutations in gurken and torpedo cause a ventralization in the follicle cell epithelium during Drosophila oogenesis and in the pattern of the embryo that develops in the resultant egg. Both genes lie midway in an epistatic series between fs(1)K10 and dorsal; the mutations block the dorsalization normally observed in K1...

journal_title：Cell

authors： Schüpbach T

更新日期：1987-06-05 00:00:00

abstract：:Synaptotagmin is an abundant synaptic vesicle-associated protein proposed to be involved in calcium-mediated neurotransmitter release. Our molecular and genetic results demonstrate that, although synaptotagmin is required for the proper function of the presynaptic nerve terminal in C. elegans, some neurotransmitter re...

journal_title：Cell

authors： Nonet ML,Grundahl K,Meyer BJ,Rand JB

更新日期：1993-07-02 00:00:00

abstract：:We have investigated whether histone H1 is present on active Balbiani ring genes in the salivary glands of Chironomus tentans using immunoelectron microscopy. The genes were studied in two activity states: maximally activated genes with a fully extended template and repressed genes in a 30 nm fiber conformation. Histo...

journal_title：Cell

authors： Ericsson C,Grossbach U,Björkroth B,Daneholt B

更新日期：1990-01-12 00:00:00

abstract：:Plant seedling development is capable of following 1 of 2 distinct morphogenic pathways: skotomorphogenesis in darkness and photomorphogenesis in light. Dark-grown Arabidopsis seedlings with recessive mutations at the constitutively photomorphogenic (COP1) locus indicate that the wild-type COP1 protein represses photo...

journal_title：Cell

authors： Deng XW,Matsui M,Wei N,Wagner D,Chu AM,Feldmann KA,Quail PH

更新日期：1992-11-27 00:00:00

abstract：:The high affinity receptor that binds the Fc domain of immunoglobulin G (IgG) subclasses 1 and 3 (Fc gamma RI) mediates important immune defense functions by inducing cell surface changes on human leukocytes. In this article, we document direct high affinity binding of Fc gamma RI to the actin filament cross-linking p...

journal_title：Cell

authors： Ohta Y,Stossel TP,Hartwig JH

更新日期：1991-10-18 00:00:00

abstract：:The maternal Dorsal regulatory gradient initiates the differentiation of several tissues in the early Drosophila embryo. Whole-genome microarray assays identified as many as 40 new Dorsal target genes, which encode a broad spectrum of cell signaling proteins and transcription factors. Evidence is presented that a tiss...

journal_title：Cell

authors： Stathopoulos A,Van Drenth M,Erives A,Markstein M,Levine M

更新日期：2002-11-27 00:00:00

abstract：:Inductive signals cause conversion of mesenchyme into epithelia during the formation of many organs. Yet a century of study has not revealed the inducing molecules. Using a standard model of induction, we found that ureteric bud cells secrete factors that convert kidney mesenchyme to epithelia that, remarkably, then f...

journal_title：Cell

authors： Barasch J,Yang J,Ware CB,Taga T,Yoshida K,Erdjument-Bromage H,Tempst P,Parravicini E,Malach S,Aranoff T,Oliver JA

更新日期：1999-11-12 00:00:00

abstract：:Mammalian models of longevity are related primarily to caloric restriction and alterations in metabolism. We examined mice in which type 5 adenylyl cyclase (AC5) is knocked out (AC5 KO) and which are resistant to cardiac stress and have increased median lifespan of approximately 30%. AC5 KO mice are protected from red...

journal_title：Cell

authors： Yan L,Vatner DE,O'Connor JP,Ivessa A,Ge H,Chen W,Hirotani S,Ishikawa Y,Sadoshima J,Vatner SF

更新日期：2007-07-27 00:00:00

abstract：:Spotted fever group (SFG) rickettsiae are human pathogens that infect cells in the vasculature. They disseminate through host tissues by a process of cell-to-cell spread that involves protrusion formation, engulfment, and vacuolar escape. Other bacterial pathogens rely on actin-based motility to provide a physical for...

journal_title：Cell

authors： Lamason RL,Bastounis E,Kafai NM,Serrano R,Del Álamo JC,Theriot JA,Welch MD

更新日期：2016-10-20 00:00:00

abstract：:Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders, inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The mechanisms underlying CB2 activation and signaling are poorly understood but critical for drug design. Here we report the cryo-EM structure of the ...

journal_title：Cell

authors： Xing C,Zhuang Y,Xu TH,Feng Z,Zhou XE,Chen M,Wang L,Meng X,Xue Y,Wang J,Liu H,McGuire TF,Zhao G,Melcher K,Zhang C,Xu HE,Xie XQ

更新日期：2020-02-20 00:00:00

abstract：:Balancing the capacity for protein maturation with changes in protein flux through the endoplasmic reticulum (ER) is crucial for maintaining ER homeostasis. In this issue, Merksamer et al. (2008) exploit a redox-sensitive fluorescent protein to monitor the environment inside the ER of living yeast, illuminating how th...

journal_title：Cell

authors： Kang SW,Hegde RS

更新日期：2008-11-28 00:00:00

abstract：:To elucidate the evolutionary origin of nervous system centralization, we investigated the molecular architecture of the trunk nervous system in the annelid Platynereis dumerilii. Annelids belong to Bilateria, an evolutionary lineage of bilateral animals that also includes vertebrates and insects. Comparing nervous sy...

journal_title：Cell

authors： Denes AS,Jékely G,Steinmetz PR,Raible F,Snyman H,Prud'homme B,Ferrier DE,Balavoine G,Arendt D

更新日期：2007-04-20 00:00:00

abstract：:The molybdenum-containing enzyme sulfite oxidase catalyzes the conversion of sulfite to sulfate, the terminal step in the oxidative degradation of cysteine and methionine. Deficiency of this enzyme in humans usually leads to major neurological abnormalities and early death. The crystal structure of chicken liver sulfi...

journal_title：Cell

authors： Kisker C,Schindelin H,Pacheco A,Wehbi WA,Garrett RM,Rajagopalan KV,Enemark JH,Rees DC

更新日期：1997-12-26 00:00:00

abstract：:The elucidation of the genetic code remains among the most influential discoveries in biology. While innumerable studies have validated the general universality of the code and its value in predicting and analyzing protein coding sequences, established and emerging work has also suggested that full genome decryption m...

journal_title：Cell

authors： Brar GA

更新日期：2016-12-15 00:00:00

abstract：:Two papers published in 1984 by the Varshavsky laboratory revealed that the ubiquitin/proteasome pathway is the principal system for degradation of short-lived proteins in mammalian cells, setting the stage for future demonstrations of this pathway's many regulatory roles. This perspective discusses the impact of thos...

journal_title：Cell

authors： Pickart CM

更新日期：2004-01-23 00:00:00

abstract：:Mice deficient for interleukin-2 develop normally during the first 3-4 weeks of age. However, later on they become severely compromised, and about 50% of the animals die between 4 and 9 weeks after birth. Of the remaining mice, 100% develop an inflammatory bowel disease with striking clinical and histological similari...

journal_title：Cell

authors： Sadlack B,Merz H,Schorle H,Schimpl A,Feller AC,Horak I

更新日期：1993-10-22 00:00:00

abstract：:Nijmegen breakage syndrome (NBS) is an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Cells from NBS patients are hypersensitive to ionizing radiation with cytogenetic features indistinguishable from ataxia telangiect...

journal_title：Cell

authors： Varon R,Vissinga C,Platzer M,Cerosaletti KM,Chrzanowska KH,Saar K,Beckmann G,Seemanová E,Cooper PR,Nowak NJ,Stumm M,Weemaes CM,Gatti RA,Wilson RK,Digweed M,Rosenthal A,Sperling K,Concannon P,Reis A

更新日期：1998-05-01 00:00:00

abstract：:Mycobacterium leprae causes leprosy and is unique among mycobacterial diseases in producing peripheral neuropathy. This debilitating morbidity is attributed to axon demyelination resulting from direct interaction of the M. leprae-specific phenolic glycolipid 1 (PGL-1) with myelinating glia and their subsequent infecti...

journal_title：Cell

authors： Madigan CA,Cambier CJ,Kelly-Scumpia KM,Scumpia PO,Cheng TY,Zailaa J,Bloom BR,Moody DB,Smale ST,Sagasti A,Modlin RL,Ramakrishnan L

更新日期：2017-08-24 00:00:00

abstract：:The sigma factor sigma 70 of E. coli RNA polymerase acts not only in initiation, but also at an early stage of elongation to induce a transcription pause, and simultaneously to allow the phage lambda gene Q transcription antiterminator to act. We identify the signal in DNA that induces early pausing to be a version of...

journal_title：Cell

authors： Ring BZ,Yarnell WS,Roberts JW

更新日期：1996-08-09 00:00:00