Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex.

abstract：:Proteotypes, like genotypes, have been found to vary between individuals in several studies, but consistent molecular functional traits across studies remain to be quantified. In a meta-analysis of 11 proteomics datasets from humans and mice, we use co-variation of proteins in known functional modules across datasets ...

journal_title：Cell

authors： Romanov N,Kuhn M,Aebersold R,Ori A,Beck M,Bork P

更新日期：2019-05-16 00:00:00

abstract：:All-trans retinoic acid (RA) has previously been shown to modulate the transcriptional properties of the retinoic acid receptor (RAR) and retinoid X receptor (RXR). The inability of all-trans RA to bind to RXR suggests that it may be metabolized to a more active high affinity ligand. We report here an experimental app...

journal_title：Cell

authors： Heyman RA,Mangelsdorf DJ,Dyck JA,Stein RB,Eichele G,Evans RM,Thaller C

更新日期：1992-01-24 00:00:00

abstract：:Using immobilized PDGF receptor as an affinity reagent, we purified an 85 kd protein (p85) from cell lysates and we cloned its cDNA. The protein contains an SH3 domain and two SH2 domains that are homologous to domains found in several receptor-associated enzymes. Recombinant p85 overexpressed in mammalian cells inhib...

journal_title：Cell

authors： Escobedo JA,Navankasattusas S,Kavanaugh WM,Milfay D,Fried VA,Williams LT

更新日期：1991-04-05 00:00:00

abstract：:The scrapie (PrPSc) and cellular (PrPC) prion proteins are encoded by the same gene, and their different properties are thought to arise from posttranslational modifications. We have found a phosphatidylinositol glycolipid on both PrPC and PrP 27-30 (derived from PrPSc by limited proteolysis at the amino terminus). Et...

journal_title：Cell

authors： Stahl N,Borchelt DR,Hsiao K,Prusiner SB

更新日期：1987-10-23 00:00:00

abstract：:Germinal centers develop in peripheral lymphatic tissue during the primary immune response and may play a crucial role in affinity maturation. We have compared the diversification of the antigen-specific repertoire of B cells, both from within and from outside the germinal centers, during the murine response to 2-phen...

journal_title：Cell

authors： Berek C,Berger A,Apel M

更新日期：1991-12-20 00:00:00

abstract：:Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond inde...

journal_title：Cell

authors： Welz PS,Zinna VM,Symeonidi A,Koronowski KB,Kinouchi K,Smith JG,Guillén IM,Castellanos A,Furrow S,Aragón F,Crainiciuc G,Prats N,Caballero JM,Hidalgo A,Sassone-Corsi P,Benitah SA

更新日期：2019-05-30 00:00:00

abstract：:The kinetics of association of epidermal growth factor (EGF) and diferric-transferrin (TF) with clathrin-coated membranes of KB cells were examined using anti-clathrin antibody bound to Staphylococcus aureus. The ligands were bound to cells at 4 degrees C and after warming to 30 degrees C for 5 min, both ligands were ...

journal_title：Cell

authors： Hanover JA,Willingham MC,Pastan I

更新日期：1984-12-01 00:00:00

abstract：:Activating mutations of FLT3 occur in about 30% of acute myeloid leukemia (AML) cases and are associated with relapse and poor prognosis. Midostaurin is the first drug approved for AML since 2000, and the first multi-kinase inhibitor approved for the FLT3-mutant subtype. To view this Bench to Bedside, open or download...

journal_title：Cell

authors： Rasko JEJ,Hughes TP

更新日期：2017-11-16 00:00:00

abstract：:Motile cells extend a leading edge by assembling a branched network of actin filaments that produces physical force as the polymers grow beneath the plasma membrane. A core set of proteins including actin, Arp2/3 complex, profilin, capping protein, and ADF/cofilin can reconstitute the process in vitro, and mathematica...

journal_title：Cell

authors： Pollard TD,Borisy GG

更新日期：2003-02-21 00:00:00

abstract：:The JAK/STAT signaling pathway, renowned for its effects on cell proliferation and survival, is constitutively active in various human cancers, including ovarian. We have found that JAK and STAT are required to convert the border cells in the Drosophila ovary from stationary, epithelial cells to migratory, invasive ce...

journal_title：Cell

authors： Silver DL,Montell DJ

更新日期：2001-12-28 00:00:00

abstract：:When the human beta-globin gene is transfected into Hela cells, no beta-globin RNA is detected unless the gene is linked to a viral transcription enhancer. In this paper we show that trans-acting adenovirus and herpesvirus (pseudorabies) transcriptional regulatory proteins can circumvent this enhancer requirement for ...

journal_title：Cell

authors： Green MR,Treisman R,Maniatis T

更新日期：1983-11-01 00:00:00

abstract：:A selection procedure is described that should allow the genetic identification of cellular components involved in the process of protein localization in Escherichia coli. This procedure makes use of mutations that alter the signal sequence of the lambda receptor protein (product of the lamB gene), and prevent export ...

journal_title：Cell

authors： Emr SD,Hanley-Way S,Silhavy TJ

更新日期：1981-01-01 00:00:00

abstract：:We analyzed a family of proteins from hepatoma cell nuclei that bind to interleukin-6 responsive elements (IL-6REs) of several acute-phase genes. This family is characterized by leucine zipper domains compatible with that of the CCAAT/enhancer binding protein (C/EBP). A cDNA clone coding for a member of the family, IL...

journal_title：Cell

authors： Poli V,Mancini FP,Cortese R

更新日期：1990-11-02 00:00:00

abstract：:The achaete-scute gene complex (AS-C), involved in differentiation of the sensory chaetes of D. melanogaster, and the yellow locus have been cloned. The yellow locus is the most distal and is followed, proximally, by the achaete and the scute loci. In the scute locus (75 kb), three transcription units separated by lon...

journal_title：Cell

authors： Campuzano S,Carramolino L,Cabrera CV,Ruíz-Gómez M,Villares R,Boronat A,Modolell J

更新日期：1985-02-01 00:00:00

abstract：:Deletion analysis was carried out on the human 7SK RNA gene to map regions essential for in vitro transcription by RNA polymerase III. The sequence promoting transcription is located between 37 and 3 bp upstream of the 7SK RNA coding region. RNA polymerase III transcription of adjacent plasmid sequences can be directe...

journal_title：Cell

authors： Murphy S,Di Liegro C,Melli M

更新日期：1987-10-09 00:00:00

abstract：:The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion. ...

journal_title：Cell

authors： Dimitrov DS

更新日期：2003-12-12 00:00:00

abstract：:The small ribosomal subunit performs the decoding of genetic information during translation. The structure of that from Thermus thermophilus shows that the decoding center, which positions mRNA and three tRNAs, is constructed entirely of RNA. The entrance to the mRNA channel will encircle the message when a latch-like...

journal_title：Cell

authors： Schluenzen F,Tocilj A,Zarivach R,Harms J,Gluehmann M,Janell D,Bashan A,Bartels H,Agmon I,Franceschi F,Yonath A

更新日期：2000-09-01 00:00:00

abstract：:To defend cells against viruses, the MAVS (mitochondrial antiviral signaling) adaptor protein initiates an antiviral signaling cascade from mitochondrial membranes. In this issue, Dixit et al. (2010) show that MAVS also localizes to the membranes of peroxisomes, where it rapidly induces expression of a subset of antiv...

journal_title：Cell

authors： Sharma S,Fitzgerald KA

更新日期：2010-05-14 00:00:00

abstract：:The mTORC1 kinase is a master growth regulator that senses many environmental cues, including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9 is an arginine sensor for the mTORC1 path...

journal_title：Cell

authors： Wyant GA,Abu-Remaileh M,Wolfson RL,Chen WW,Freinkman E,Danai LV,Vander Heiden MG,Sabatini DM

更新日期：2017-10-19 00:00:00

abstract：:The triskelion shape of the clathrin molecule enables it to form the polyhedral protein network that covers clathrin-coated pits and vesicles. Domains within the clathrin heavy chain that are responsible for maintaining triskelion shape and function were identified and localized. Sequences that mediate trimerization a...

journal_title：Cell

authors： Näthke IS,Heuser J,Lupas A,Stock J,Turck CW,Brodsky FM

更新日期：1992-03-06 00:00:00

abstract：:Erythroid Krüppel-like factor (EKLF) is necessary for stage-specific expression of the human beta-globin gene. We show that EKLF requires a SWI/SNF-related chromatin remodeling complex, EKLF coactivator-remodeling complex 1 (E-RC1), to generate a DNase I hypersensitive, transcriptionally active beta-globin promoter on...

journal_title：Cell

authors： Armstrong JA,Bieker JJ,Emerson BM

更新日期：1998-10-02 00:00:00

abstract：:Neurons are frequently classified into distinct types on the basis of structural, physiological, or genetic attributes. To better constrain the definition of neuronal cell types, we characterized the transcriptomes and intrinsic physiological properties of over 4,200 mouse visual cortical GABAergic interneurons and re...

journal_title：Cell

authors： Gouwens NW,Sorensen SA,Baftizadeh F,Budzillo A,Lee BR,Jarsky T,Alfiler L,Baker K,Barkan E,Berry K,Bertagnolli D,Bickley K,Bomben J,Braun T,Brouner K,Casper T,Crichton K,Daigle TL,Dalley R,de Frates RA,Dee N,Dest

更新日期：2020-11-12 00:00:00

abstract：:The topology of E. coli inner membrane proteins depends primarily on the distribution of positively charged residues in the molecule. We have constructed model proteins with four potential transmembrane stretches and have systematically explored the topological effects of lysines placed in the loops connecting the tra...

journal_title：Cell

authors： Gafvelin G,von Heijne G

更新日期：1994-05-06 00:00:00

abstract：:Four RNA products have been characterized from a soluble system that accurately splices purified substrate RNA. The labeled substrate RNA contained the first and second exons of the major late transcription unit of adenovirus 2 and a shortened form of the first intervening sequence. One of these RNA products was the e...

journal_title：Cell

authors： Grabowski PJ,Padgett RA,Sharp PA

更新日期：1984-06-01 00:00:00

abstract：:We have tested the hypothesis that DNA methylation patterns are replicated in the somatic cells of vertebrates. Using M-Hpa II, the modification enzyme from Haemophilus parainfluenzae which methylates the internal cytosine residues in the sequence 5'CCGG 3' GGCC, we methylated bacteriophage phi X174 RF DNA and the clo...

journal_title：Cell

authors： Wigler M,Levy D,Perucho M

更新日期：1981-04-01 00:00:00

abstract：:The protein product of the human Duchenne muscular dystrophy locus (DMD) and its mouse homolog (mDMD) have been identified by using polyclonal antibodies directed against fusion proteins containing two distinct regions of the mDMD cDNA. The DMD protein is shown to be approximately 400 kd and to represent approximately...

journal_title：Cell

authors： Hoffman EP,Brown RH Jr,Kunkel LM

更新日期：1987-12-24 00:00:00

abstract：:The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor. ...

journal_title：Cell

authors： Marchese FP,Huarte M

更新日期：2018-05-31 00:00:00

abstract：:The segment polarity genes engrailed and wingless are expressed in neighboring stripes of cells on opposite sides of the Drosophila parasegment boundary. Each gene is mutually required for maintenance of the other's expression; continued expression of both also requires several other segment polarity genes. We show he...

journal_title：Cell

authors： Lee JJ,von Kessler DP,Parks S,Beachy PA

更新日期：1992-10-02 00:00:00

abstract：:Finding the components of cellular circuits and determining their functions systematically remains a major challenge in mammalian cells. Here, we introduced genome-wide pooled CRISPR-Cas9 libraries into dendritic cells (DCs) to identify genes that control the induction of tumor necrosis factor (Tnf) by bacterial lipop...

journal_title：Cell

authors： Parnas O,Jovanovic M,Eisenhaure TM,Herbst RH,Dixit A,Ye CJ,Przybylski D,Platt RJ,Tirosh I,Sanjana NE,Shalem O,Satija R,Raychowdhury R,Mertins P,Carr SA,Zhang F,Hacohen N,Regev A

更新日期：2015-07-30 00:00:00

abstract：:White adipose tissue (WAT) serves as the primary energy depot in the body by storing fat. During development, fat cell precursors (i.e., preadipocytes) undergo a hypertrophic response as they mature into lipid-laden adipocytes. However, the mechanisms that regulate adipocyte size and mass remain undefined. Herein, we ...

journal_title：Cell

authors： Chun TH,Hotary KB,Sabeh F,Saltiel AR,Allen ED,Weiss SJ

更新日期：2006-05-05 00:00:00