Abstract：
:Proteotypes, like genotypes, have been found to vary between individuals in several studies, but consistent molecular functional traits across studies remain to be quantified. In a meta-analysis of 11 proteomics datasets from humans and mice, we use co-variation of proteins in known functional modules across datasets and individuals to obtain a consensus landscape of proteotype variation. We find that individuals differ considerably in both protein complex abundances and stoichiometry. We disentangle genetic and environmental factors impacting these metrics, with genetic sex and specific diets together explaining 13.5% and 11.6% of the observed variation of complex abundance and stoichiometry, respectively. Sex-specific differences, for example, include various proteins and complexes, where the respective genes are not located on sex-specific chromosomes. Diet-specific differences, added to the individual genetic backgrounds, might become a starting point for personalized proteotype modulation toward desired features.
journal_name
Celljournal_title
Cellauthors
Romanov N,Kuhn M,Aebersold R,Ori A,Beck M,Bork Pdoi
10.1016/j.cell.2019.03.015subject
Has Abstractpub_date
2019-05-16 00:00:00pages
1308-1318.e10issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(19)30277-6journal_volume
177pub_type
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