Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF beta receptor family.

abstract：:Human hepatitis B virus core protein expressed in E. coli assembles into two sizes of particle. We have determined their three-dimensional structures by electron cryomicroscopy and image processing. The large and small particles correspond to triangulation number T = 4 and T = 3 dimer clustered packings, containing 24...

journal_title：Cell

authors： Crowther RA,Kiselev NA,Böttcher B,Berriman JA,Borisova GP,Ose V,Pumpens P

更新日期：1994-06-17 00:00:00

abstract：:Beta-arrestin1 is a multifunctional protein critically involved in signal transduction. Recently, it is also identified as a nuclear transcriptional regulator, but the underlying mechanisms and physiological significance remain to be explored. Here, we identified beta-arrestin1 as an evolutionarily conserved protein e...

journal_title：Cell

authors： Yue R,Kang J,Zhao C,Hu W,Tang Y,Liu X,Pei G

更新日期：2009-10-30 00:00:00

abstract：:The dual host range virus HIX has been previously characterized as an envelope gene recombinant between Moloney murine leukemia virus (Mo-MuLV) and an unidentified xenotropic murine leukemia virus. Using long reverse transcripts of Mo-MuLV, a region of nonhomology has been mapped by electron microscopic analysis of he...

journal_title：Cell

authors： Donoghue DJ,Rothenberg E,Hopkins N,Baltimore D,Sharp PA

更新日期：1978-08-01 00:00:00

abstract：:Recent studies are beginning to shed light on the mechanism of ribosome-catalyzed peptide bond formation. ...

journal_title：Cell

authors： Green R,Lorsch JR

更新日期：2002-09-20 00:00:00

abstract：:RNA polymerase II (RNAPII) lies at the core of dynamic control of gene expression. Using 53 RNAPII point mutants, we generated a point mutant epistatic miniarray profile (pE-MAP) comprising ∼60,000 quantitative genetic interactions in Saccharomyces cerevisiae. This analysis enabled functional assignment of RNAPII subd...

journal_title：Cell

authors： Braberg H,Jin H,Moehle EA,Chan YA,Wang S,Shales M,Benschop JJ,Morris JH,Qiu C,Hu F,Tang LK,Fraser JS,Holstege FC,Hieter P,Guthrie C,Kaplan CD,Krogan NJ

更新日期：2013-08-15 00:00:00

abstract：:A key feature of plants (as opposed to animals) is their ability to establish new organs not only during embryogenesis, but also throughout their development. A master regulator of organ initiation in plants is the phytohormone auxin. Auxin acts locally as a morphogen and is directionally transported from cell to cell...

journal_title：Cell

authors： Jaillais Y,Santambrogio M,Rozier F,Fobis-Loisy I,Miège C,Gaude T

更新日期：2007-09-21 00:00:00

abstract：:Properties of human anticentromere autoantibodies were analyzed. In intact cells or isolated cell fractions, these sera stain the centromeres of mitotic chromosomes and discrete speckles (prekinetochores) in nuclei. Staining is also retained in matrix preparations from nuclei or chromosomes. Immunoprecipitation or imm...

journal_title：Cell

authors： Cox JV,Schenk EA,Olmsted JB

更新日期：1983-11-01 00:00:00

abstract：:Cells producing avian sarcoma virus (ASV) contain at least three virus-specific mRNAs, two of which are encoded within the 3' half of the viral genome. Each of these viral RNAs can hybridize with single-stranded DNA(cDNA5') that is complementary to a sequence of 101 nucleotides found at the 5' terminus of the ASV geno...

journal_title：Cell

authors： Cordell B,Weiss SR,Varmus HE,Bishop JM

更新日期：1978-09-01 00:00:00

abstract：:We have isolated cDNA clones encoding the four different forms of mouse myelin basic protein (MBP) and have analyzed the structure of the MBP gene. The three larger forms of MBP differ from the smallest by the inclusion of either or both of two short amino acid sequences at positions 57 and 124 of the smallest protein...

journal_title：Cell

authors： de Ferra F,Engh H,Hudson L,Kamholz J,Puckett C,Molineaux S,Lazzarini RA

更新日期：1985-12-01 00:00:00

abstract：:We have determined the high resolution crystal structure of the A domain from the alpha chain of integrin CR3. The domain adopts a classic alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site at its surface. One of the coordinating ligands is the glutamate side chain from another A domain molecule...

journal_title：Cell

authors： Lee JO,Rieu P,Arnaout MA,Liddington R

更新日期：1995-02-24 00:00:00

abstract：:Recombinant DNAs containing the E. coli plasmid pSC101 and mouse cell (La9) mitochondrial DNA (mtDNA) were formed in vitro via ligation of DNA fragments from limit EcoRI endonuclease digests and were used to transform E. coli K12. Four structurally different recombinant plasmid DNAs from transformed clones were charac...

journal_title：Cell

authors： Brown WM,Watson RM,Vinograd J,Tait KM,Boyer HW,Goodman HM

更新日期：1976-04-01 00:00:00

abstract：:The crystal structure of a proteolytic subfragment from scallop striated muscle myosin, complexed with MgADP, has been solved at 2.5 A resolution and reveals an unusual conformation of the myosin head. The converter and the lever arm are in very different positions from those in either the pre-power stroke or near-rig...

journal_title：Cell

authors： Houdusse A,Kalabokis VN,Himmel D,Szent-Györgyi AG,Cohen C

更新日期：1999-05-14 00:00:00

abstract：:The mec-3 gene is essential for proper differentiation of the set of six touch receptor neurons in C. elegans. In mutants lacking mec-3 activity, the touch receptors express none of their unique differentiated features and appear to be transformed into other types of neurons. We cloned the mec-3 gene by transposon tag...

journal_title：Cell

authors： Way JC,Chalfie M

更新日期：1988-07-01 00:00:00

abstract：:We have identified a yeast protein that binds specifically to the ARS consensus sequence. By two-step chromatography we have purified the factor to apparent homogeneity as a single polypeptide of 67 kd. The purified ARS consensus-binding protein (ACBP) recognizes the ARS consensus of the four genomic ARS elements test...

journal_title：Cell

authors： Hofmann JF,Gasser SM

更新日期：1991-03-08 00:00:00

abstract：:The monoclonal antibody ECCD-1 inhibits Ca2+-dependent cell-cell adhesion in teratocarcinoma cells, recognizing a cell surface component of MW 124,000. When mouse embryos at various preimplantation stages were cultured in the presence of ECCD-1, the compacted morphology of the 8- to 16-cell-stage embryos was destroyed...

journal_title：Cell

authors： Shirayoshi Y,Okada TS,Takeichi M

更新日期：1983-12-01 00:00:00

abstract：:We describe the comprehensive characterization of homeodomain DNA-binding specificities from a metazoan genome. The analysis of all 84 independent homeodomains from D. melanogaster reveals the breadth of DNA sequences that can be specified by this recognition motif. The majority of these factors can be organized into ...

journal_title：Cell

authors： Noyes MB,Christensen RG,Wakabayashi A,Stormo GD,Brodsky MH,Wolfe SA

更新日期：2008-06-27 00:00:00

abstract：:Distinct classes of neurons are generated at defined positions in the ventral neural tube in response to a gradient of Sonic Hedgehog (Shh) activity. A set of homeodomain transcription factors expressed by neural progenitors act as intermediaries in Shh-dependent neural patterning. These homeodomain factors fall into ...

journal_title：Cell

authors： Briscoe J,Pierani A,Jessell TM,Ericson J

更新日期：2000-05-12 00:00:00

abstract：:The spindle pole body (SPB) is the microtubule organizing center (MTOC) in the yeast Saccharomyces that plays a pivotal role in such diverse processes as mitosis, budding, and mating. We have used cryoelectron microscopy and image processing to study the structure of isolated diploid SPBs. We show that SPBs are presen...

journal_title：Cell

authors： Bullitt E,Rout MP,Kilmartin JV,Akey CW

更新日期：1997-06-27 00:00:00

abstract：:How and when memory T cells form during an immune response are long-standing questions. To better understand memory CD8 T cell development, a time course of gene expression and functional changes in antigen-specific T cells during viral infection was evaluated. The expression of many genes continued to change after vi...

journal_title：Cell

authors： Kaech SM,Hemby S,Kersh E,Ahmed R

更新日期：2002-12-13 00:00:00

abstract：:The exchange of metabolites between the mitochondrial matrix and the cytosol depends on β-barrel channels in the outer membrane and α-helical carrier proteins in the inner membrane. The essential translocase of the inner membrane (TIM) chaperones escort these proteins through the intermembrane space, but the structura...

journal_title：Cell

authors： Weinhäupl K,Lindau C,Hessel A,Wang Y,Schütze C,Jores T,Melchionda L,Schönfisch B,Kalbacher H,Bersch B,Rapaport D,Brennich M,Lindorff-Larsen K,Wiedemann N,Schanda P

更新日期：2018-11-15 00:00:00

abstract：:What happens to organelles during mitosis, and how they are apportioned to each of the daughter cells, is not completely clear. We have devised a procedure to address whether Golgi membranes fuse with the Endoplasmic Reticulum (ER) during mitosis via the detection of interactions between ER and Golgi proteins. This pr...

journal_title：Cell

authors： Pecot MY,Malhotra V

更新日期：2004-01-09 00:00:00

abstract：:Misfolded proteins of the ER are retrotranslocated to the cytosol, where they are polyubiquitinated, extracted from the membrane, and degraded by the proteasome. To investigate how the ER-associated Degradation (ERAD) machinery can accomplish retrotranslocation of a misfolded luminal protein domain across a lipid bila...

journal_title：Cell

authors： Baldridge RD,Rapoport TA

更新日期：2016-07-14 00:00:00

abstract：:Cultured preadipose 3T3 cells are induced or enabled to undergo adipose conversion in the presence of an extract of pituitary gland. Adipogenic activity is found in standard growth hormone preparations derived from different species. Further purification of rat growth hormone by several methods does not remove its adi...

journal_title：Cell

authors： Morikawa M,Nixon T,Green H

更新日期：1982-07-01 00:00:00

abstract：:Nine transcripts complementary to mouse L cell mitochondrial DNA have been detected, sized and mapped to restriction fragments using the method of Berk and Sharp (1977). RNA isolated from L cell mitochondria was hybridized to 32P-labeled, cloned L cell mitochondrial DNA restriction fragments in 70% formamide under con...

journal_title：Cell

authors： Battey J,Clayton DA

更新日期：1978-05-01 00:00:00

abstract：:In this issue of Cell, Shin et al. report the first live-cell imaging of a fusion pore. Directly visualized pores in neuroendocrine cells can be much larger than expected yet not require vesicular full-collapse. These fusion-fission pores have diverse fates arising from opposing dynamin-driven pore constriction and F-...

journal_title：Cell

authors： Eyring KW,Tsien RW

更新日期：2018-05-03 00:00:00

abstract：:Portions of the nascent chain are exposed to the lumen, the cytosol, or neither at different stages during the cotranslational integration of a protein into the ER membrane, as shown by compartment-specific collisional quenching of fluorophores incorporated into the polypeptide. The opening or closing of each end of t...

journal_title：Cell

authors： Liao S,Lin J,Do H,Johnson AE

更新日期：1997-07-11 00:00:00

abstract：:The ephrin/Eph system plays a central role in neuronal circuit formation; however, its downstream effectors are poorly understood. Here we show that alpha-chimerin Rac GTPase-activating protein mediates ephrinB3/EphA4 forward signaling. We discovered a spontaneous mouse mutation, miffy (mfy), which results in a rabbit...

journal_title：Cell

authors： Iwasato T,Katoh H,Nishimaru H,Ishikawa Y,Inoue H,Saito YM,Ando R,Iwama M,Takahashi R,Negishi M,Itohara S

更新日期：2007-08-24 00:00:00

abstract：:The single most frequent cancer-causing mutation across all heterotrimeric G proteins is R201C in Gαs. The current model explaining the gain-of-function activity of the R201 mutations is through the loss of GTPase activity and resulting inability to switch off to the GDP state. Here, we find that the R201C mutation ca...

journal_title：Cell

authors： Hu Q,Shokat KM

更新日期：2018-05-17 00:00:00

abstract：:Production of nerve growth factor (NGF) was assessed in cultures of human T and B lymphocytes and macrophages. NGF was constitutively produced by B cells only, which also expressed surface p140trk-A and p75NGFR molecules and hence efficiently bound and internalized the cytokine. Neutralization of endogenous NGF caused...

journal_title：Cell

authors： Torcia M,Bracci-Laudiero L,Lucibello M,Nencioni L,Labardi D,Rubartelli A,Cozzolino F,Aloe L,Garaci E

更新日期：1996-05-03 00:00:00

abstract：:We have shown that in fixed mitotic chromosomes from female G. gerbillus cells the inactive X chromosome is distinctly less sensitive to DNAase I than the active X chromosome, as demonstrated by in situ nick translation. These results indicated that the specific chromatin conformation that renders potentially active g...

journal_title：Cell

authors： Kerem BS,Goitein R,Diamond G,Cedar H,Marcus M

更新日期：1984-09-01 00:00:00