Abstract：
:Distinct classes of neurons are generated at defined positions in the ventral neural tube in response to a gradient of Sonic Hedgehog (Shh) activity. A set of homeodomain transcription factors expressed by neural progenitors act as intermediaries in Shh-dependent neural patterning. These homeodomain factors fall into two classes: class I proteins are repressed by Shh and class II proteins require Shh signaling for their expression. The profile of class I and class II protein expression defines five progenitor domains, each of which generates a distinct class of postmitotic neurons. Cross-repressive interactions between class I and class II proteins appear to refine and maintain these progenitor domains. The combinatorial expression of three of these proteins--Nkx6.1, Nkx2.2, and Irx3--specifies the identity of three classes of neurons generated in the ventral third of the neural tube.
journal_name
Celljournal_title
Cellauthors
Briscoe J,Pierani A,Jessell TM,Ericson Jdoi
10.1016/s0092-8674(00)80853-3subject
Has Abstractpub_date
2000-05-12 00:00:00pages
435-45issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(00)80853-3journal_volume
101pub_type
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