Abstract：
:The 2013-2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality rates. We generated a genomic catalog of almost 200 LASV sequences from clinical and rodent reservoir samples. We show that whereas the 2013-2015 EVD epidemic is fueled by human-to-human transmissions, LASV infections mainly result from reservoir-to-human infections. We elucidated the spread of LASV across West Africa and show that this migration was accompanied by changes in LASV genome abundance, fatality rates, codon adaptation, and translational efficiency. By investigating intrahost evolution, we found that mutations accumulate in epitopes of viral surface proteins, suggesting selection for immune escape. This catalog will serve as a foundation for the development of vaccines and diagnostics. VIDEO ABSTRACT.
journal_name
Celljournal_title
Cellauthors
Andersen KG,Shapiro BJ,Matranga CB,Sealfon R,Lin AE,Moses LM,Folarin OA,Goba A,Odia I,Ehiane PE,Momoh M,England EM,Winnicki S,Branco LM,Gire SK,Phelan E,Tariyal R,Tewhey R,Omoniwa O,Fullah M,Fonnie R,Fonnie M,doi
10.1016/j.cell.2015.07.020subject
Has Abstractpub_date
2015-08-13 00:00:00pages
738-50issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(15)00897-1journal_volume
162pub_type
杂志文章相关文献
CELL文献大全abstract：:TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2013.12.002
更新日期：2013-12-19 00:00:00
abstract：:Mucus production by goblet cells of the large intestine serves as a crucial antimicrobial protective mechanism at the interface between the eukaryotic and prokaryotic cells of the mammalian intestinal ecosystem. However, the regulatory pathways involved in goblet cell-induced mucus secretion remain largely unknown. He...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.01.026
更新日期：2014-02-27 00:00:00
abstract：:Xenogeneic spinal cord chimeras were constructed by grafting fragments of quail neural primordium into chick embryos at 2 days of incubation. Hatched birds displayed normal motor behavior for about 5 to 7 weeks, whereupon they developed a neurological syndrome; in the grafted spinal cord the pathological signs of the ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90395-8
更新日期：1986-04-25 00:00:00
abstract：:Members of the myocyte enhancer factor-2 (MEF2) family of MADS domain transcription factors cannot induce myogenesis in transfected fibroblasts, but when coexpressed with the myogenic basic-helix-loop-helix (bHLH) proteins MyoD or myogenin they dramatically increase the extent of myogenic conversion above that seen wi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90139-6
更新日期：1995-12-29 00:00:00
abstract：:Ku is a heterodimeric DNA end binding complex composed of 70 and 86 kDa subunits. Here, we show that Ku86 is essential for normal V(D)J recombination in vivo, as Ku86-deficient mice are severely defective for formation of coding joints. Unlike severe combined immunodeficient (scid) mice, Ku86-deficient mice are also d...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80111-7
更新日期：1996-08-09 00:00:00
abstract：:A major challenge to understanding how cells work together in the central nervous system (CNS) is the heterogeneous cellular composition of the brain. In this issue, Heiman et al. (2008) and Doyle et al. (2008) introduce a new strategy (TRAP) that enables the profiling of translated mRNAs in specific CNS cell populati...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2008.10.031
更新日期：2008-11-14 00:00:00
abstract：:Cellular mRNAs exist in messenger ribonucleoprotein (mRNP) complexes, which undergo transitions during the lifetime of the mRNAs and direct posttranscriptional gene regulation. A final posttranscriptional step in gene expression is the turnover of the mRNP, which involves degradation of the mRNA and recycling of assoc...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.11.043
更新日期：2010-12-10 00:00:00
abstract：:Transduction of cellular genes by retroviruses requires two recombinations: one to form the left-hand junction between cellular gene and viral genome, the other to form the right-hand junction. Previous findings raised the possibility that the right-hand recombination might use RNA molecules as intermediates. We now p...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90016-4
更新日期：1986-03-28 00:00:00
abstract：:Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why these events occur, just as the theory of gravitation allows one to understand why cannonballs fly in parabolic arcs. The simplest examples of the eukaryotic ce...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.03.006
更新日期：2011-03-18 00:00:00
abstract：:We have examined the molecular organization of a region of mouse chromosome 17 that allows homologous recombination between wild-type and t haplotype chromosomes across a large inversion. We have used a combination of genetic mapping of restriction fragment length polymorphisms, molecular characterization of cloned re...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90078-x
更新日期：1987-03-13 00:00:00
abstract：:Transcriptional silencing is a phenomenon in which the transcription of a gene by RNA polymerase II or III is repressed or not, dependent only on the gene's chromosomal location. Two prevailing models exist for silencing: (1) steric hindrance in silenced chromatin inhibits the binding of upstream activator proteins or...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.11.030
更新日期：2005-01-14 00:00:00
abstract：:The transition from the juvenile to the adult phase of shoot development in plants is accompanied by changes in vegetative morphology and an increase in reproductive potential. Here, we describe the regulatory mechanism of this transition. We show that miR156 is necessary and sufficient for the expression of the juven...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.06.031
更新日期：2009-08-21 00:00:00
abstract：:Suppressor of Hairless (Su(H)) is required at two stages of adult sensory organ development in Drosophila. Complete loss of Su(H) function results in a "neurogenic" phenotype in imaginal discs, in which too many cells adopt the sensory organ precursor cell fate. Su(H) is also involved in controlling the fates of sensi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90641-o
更新日期：1992-06-26 00:00:00
abstract：:Many organs are composed of epithelial tubes that transport vital fluids. Such tubular organs develop in many different ways and generate tubes of widely varying sizes and structures, but always with the apical epithelial surface lining the lumen. We describe recent progress in several diverse cell culture and genetic...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/s0092-8674(02)01283-7
更新日期：2003-01-10 00:00:00
abstract：:In ciliates, small RNAs have been shown to target foreign sequences for silencing via elimination from the somatic genome. Fang et al. now reveal a set of Piwi-interacting RNAs (piRNAs) in Oxytricha trifallax that likewise enable genomic self versus nonself discrimination, this time by specifying self sequences for ge...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2012.11.032
更新日期：2012-12-07 00:00:00
abstract：:DNA transcription, replication, and repair are regulated by histone acetylation, a process that requires the generation of acetyl-coenzyme A (CoA). Here, we show that all the subunits of the mitochondrial pyruvate dehydrogenase complex (PDC) are also present and functional in the nucleus of mammalian cells. We found t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.04.046
更新日期：2014-07-03 00:00:00
abstract：:Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac mu...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2010.08.004
更新日期：2010-08-20 00:00:00
abstract：:Most inducible transcriptional programs consist of primary and secondary response genes (PRGs and SRGs) that differ in their kinetics of expression and in their requirements for new protein synthesis and chromatin remodeling. Here we show that many PRGs, in contrast to SRGs, have preassembled RNA polymerase II (Pol II...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.05.047
更新日期：2009-07-10 00:00:00
abstract：:Rare diseases are powerful windows into biological processes and can serve as models for the development of therapeutic strategies. The progress made on the premature aging disorder Progeria is a shining example of the impact that studies of rare diseases can have. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.12.028
更新日期：2014-01-30 00:00:00
abstract：:Elucidation of endogenous cellular protein-protein interactions and their networks is most desirable for biological studies. Here we report our study of endogenous human coregulator protein complex networks obtained from integrative mass spectrometry-based analysis of 3290 affinity purifications. By preserving weak pr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.05.006
更新日期：2011-05-27 00:00:00
abstract：:Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE) is implicated in geographic atrophy (GA), an advanced form of age-related macular degeneration that causes blindness in millions of individuals. The mechanism of Alu RNA-induced cytotoxicity is unknown. Here we show that DICER1 def...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.03.036
更新日期：2012-05-11 00:00:00
abstract：:Molecular codes, like postal zip codes, are generally considered a robust way to ensure the specificity of neuronal target selection. However, a code capable of unambiguously generating complex neural circuits is difficult to conceive. Here, we re-examine the notion of molecular codes in the light of developmental alg...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2015.09.031
更新日期：2015-10-08 00:00:00
abstract：:The molecular nature of mutations arising in dysgenic hybrids between P and M Drosophila melanogaster strains has been investigated. Seven independent mutations at the white locus were examined, and these fell into two classes on the basis of their genetic and structural properties. The five mutations comprising the f...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90462-7
更新日期：1982-07-01 00:00:00
abstract：:We used the interaction trap, a yeast genetic selection for interacting proteins, to isolate human cyclin-dependent kinase interactor 1 (Cdi1). In yeast, Cdi1 interacts with cyclin-dependent kinases, including human Cdc2, Cdk2, and Cdk3, but not with Ckd4. In HeLa cells, Cdi1 is expressed at the G1 to S transition, an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90498-f
更新日期：1993-11-19 00:00:00
abstract：:The activation of the tumor suppressor p53 facilitates the cellular response to genotoxic stress; however, the p53 response can only be executed if its interaction with its inhibitor Mdm2 is abolished. There have been conflicting reports on the question of whether p53 posttranslational modifications, such as phosphory...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.03.025
更新日期：2008-05-16 00:00:00
abstract：:Cell lines from rhabdomyosarcomas, which are tumors of muscle origin, have been used as models of CD4-independent HIV infection. These cell lines can be induced to differentiate in vitro. We report here that the vpr gene of HIV1 is sufficient for the differentiation of the human rhabdomyosarcoma cell line TE671. Diffe...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90073-y
更新日期：1993-02-26 00:00:00
abstract：:Spatiotemporal changes in nuclear lamina composition underlie cell-type-specific chromatin organization and cell fate, suggesting that the lamina forms a dynamic framework critical for genome function, cellular identity, and developmental potential. ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2013.02.052
更新日期：2013-03-14 00:00:00
abstract：:We have analyzed the transcriptional regulation of plastid genes during chloroplast development in illuminated spinach cotyledons and during leaf formation. The RNAs encoded by plastid genes accumulate with different kinetics during the developmental transitions. Using a novel plastid run-on transcription assay we dem...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90290-x
更新日期：1987-05-08 00:00:00
abstract：:We have isolated two adenylyl cyclase genes, designated ACA and ACG, from Dictyostelium. The proposed structure for ACA resembles that proposed for mammalian adenylyl cyclases: two large hydrophilic domains and two sets of six transmembrane spans. ACG has a novel structure, reminiscent of the membrane-bound guanylyl c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90411-5
更新日期：1992-04-17 00:00:00
abstract：:Senescence in Podospora anserina has long been shown to be under cytoplasmic control. Comparison of DNAs isolated from young and senescent cultures made it possible to detect the presence, in senescent cultures only, of a specific DNA (SEN-DNA). This DNA consists of repeated sequences arranged in a multimeric set of c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90126-9
更新日期：1980-08-01 00:00:00
