Abstract:
:Senescence in Podospora anserina has long been shown to be under cytoplasmic control. Comparison of DNAs isolated from young and senescent cultures made it possible to detect the presence, in senescent cultures only, of a specific DNA (SEN-DNA). This DNA consists of repeated sequences arranged in a multimeric set of circular molecules. In this study we have examined one particular SEN-DNA whose monomer unit is 6300 bp long. Using the Southern hybridization technique, we have demonstrated that this SEN-DNA results from the amplication of a sequence of the mitochondrial chromosome. This amplification, which resembles the process leading to rho- ("petite") mutations in yeast, is discussed in relation to the determinism of senescence.
journal_name
Celljournal_title
Cellauthors
Jamet-Vierny C,Begel O,Belcour Ldoi
10.1016/0092-8674(80)90126-9subject
Has Abstractpub_date
1980-08-01 00:00:00pages
189-94issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(80)90126-9journal_volume
21pub_type
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